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(S)-CR8

(S)-CR8 Structure
(S)-CR8 structure
CAS No.
1084893-56-0
Chemical Name:
(S)-CR8
Synonyms
CR8, (S)-Isomer;CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem;1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-, (2S)-
CBNumber:
CB33152923
Molecular Formula:
C24H29N7O
Molecular Weight:
431.53
MDL Number:
MFCD23160354
MOL File:
1084893-56-0.mol
MSDS File:
SDS
Last updated:2023-06-08 09:02:13
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(S)-CR8 Properties

Boiling point 671.4±65.0 °C(Predicted)
Density 1.27±0.1 g/cm3(Predicted)
storage temp. +2C to +8C
solubility DMSO: soluble,Ethanol: soluble
form Off-white solid
pka 14.56±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
NFPA 704
0
2 0

(S)-CR8 price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29985 (S)-CR8 1084893-56-0 1mg $44 2024-03-01 Buy
Cayman Chemical 29985 (S)-CR8 1084893-56-0 25mg $479 2024-03-01 Buy
Cayman Chemical 29985 (S)-CR8 1084893-56-0 5mg $183 2024-03-01 Buy
Cayman Chemical 29985 (S)-CR8 1084893-56-0 10mg $278 2024-03-01 Buy
Adipogen Life Sciences AG-MR-C0004-M010 (S)-CR8 ≥99%(NMR) 1084893-56-0 10mg $200 2021-12-16 Buy
Product number Packaging Price Buy
29985 1mg $44 Buy
29985 25mg $479 Buy
29985 5mg $183 Buy
29985 10mg $278 Buy
AG-MR-C0004-M010 10mg $200 Buy

(S)-CR8 Chemical Properties,Uses,Production

Description

(S)-CR8 is a second generation derivative of (R)-roscovitine and an inhibitor of cyclin-dependent kinase 1 (Cdk1/cyclin B), Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T (IC50s = 0.15, 0.08, 0.06, 0.12, and 0.11 μM, respectively). It also inhibits casein kinase CK1δ/ε (CKδ/ε) and DYRK1A (IC50s = 0.61 and 0.9 μM, respectively). (S)-CR8 reduces cell viability in human neuroblastoma cell lines, including SH-SY5Y, SK-N-AS, SK-N-BE, and IMR32 cells (IC50s = 0.43, 1.46, 0.13, and 0.14 μM, respectively). It also reduces protein levels of the survival factor Mcl-1 in SH-SY5Y cells.

Definition

ChEBI: (2S)-2-[[9-propan-2-yl-6-[[4-(2-pyridinyl)phenyl]methylamino]-2-purinyl]amino]-1-butanol is a phenylpyridine.

(S)-CR8 Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-CR8 Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd. 027-65388397 18164111589 3321478047@qq.com China 1995 55
ATK CHEMICAL COMPANY LIMITED 3429815786 13301662590 sales@atkchemical.com China 10004 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 chaolaichem@foxmail.com China 9242 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Suzhou Chenrui Biotechnology Co. LTD 17625585511 1580084073@qq.com China 473 58
JinOu Biomedical (Nanjing) Co., Ltd. 13000000000 jinoupharma@163.com China 11732 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd. 55
ATK CHEMICAL COMPANY LIMITED 55
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai SuperLan Chemcial Technique Centre 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Suzhou Chenrui Biotechnology Co. LTD 58
JinOu Biomedical (Nanjing) Co., Ltd. 58

1084893-56-0((S)-CR8)Related Search:

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CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem 1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-, (2S)- CR8, (S)-Isomer 1084893-56-0