ChemicalBook
Chinese Japanese Germany Korea

Cromolyn Disodium Salt

Description References
Cromolyn Disodium Salt
Cromolyn Disodium Salt structure
CAS No.
15826-37-6
Chemical Name:
Cromolyn Disodium Salt
Synonyms
DSCG;intal;aarane;fpl670;nasmil;Nalcro;aararre;lomudal;lomudas;nalcrom
CBNumber:
CB3413920
Molecular Formula:
C23H14O11.2Na
Formula Weight:
512.33
MOL File:
15826-37-6.mol

Cromolyn Disodium Salt Properties

Melting point:
241-2420C (dec)
storage temp. 
Refrigerator, Under Inert Atmosphere
solubility 
Soluble in water, practically insoluble in ethanol (96 per cent).
form 
neat
Water Solubility 
Soluble in water to 100mg/ml
Merck 
14,2590
Stability:
Hygroscopyc
InChIKey
VLARUOGDXDTHEH-UHFFFAOYSA-L
CAS DataBase Reference
15826-37-6(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P305+P351+P338-P261-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P280a-P304+P340-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  3249
WGK Germany  2
RTECS  DJ2380000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29329990
Toxicity LD50 in mice, rats (mg/kg): >8000 orally (Cox)

Cromolyn Disodium Salt price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C0399 Cromolyn sodium salt ≥95% 15826-37-6 1g $56.6 2018-11-20 Buy
Sigma-Aldrich 1150502 Cromolyn sodium United States Pharmacopeia (USP) Reference Standard 15826-37-6 500mg $348 2018-11-13 Buy
TCI Chemical C2521 Cromolyn Disodium Salt Hydrate >98.0%(HPLC)(T) 15826-37-6 5g $106 2018-11-22 Buy
TCI Chemical C2521 Cromolyn Disodium Salt Hydrate >98.0%(HPLC)(T) 15826-37-6 25g $370 2018-11-22 Buy
Alfa Aesar J65122 Cromolyn sodium salt, 98% 15826-37-6 1g $44.3 2018-11-13 Buy

Cromolyn Disodium Salt Chemical Properties,Uses,Production

Description

Sodium cromoglycate is the sodium salt and common market from of cromoglicic acid, which is a synthetic compound, and as a mast cell stabilizer. It is capable of inhibiting the antigen-induced bronchospasms, and thus being used to treat the asthma and allergic rhinitis. It can also be applied as an ophthalmic solution for the treatment of conjunctivitis and systemic mastocytosis and ulcerative colitis. It is capable of inhibiting the degranulation of mast cells, further preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), the mediators of type I allergic reaction. It is also capable of inhibiting the release of inflammatory leukotrienes and inhibiting calcium influx.

References

https://www.drugbank.ca/drugs/DB01003
https://en.wikipedia.org/wiki/Cromoglicic_acid

Chemical Properties

White Crystalline Powder

Uses

antiasthmatic, antiallergy

Uses

Anti Asthamatic

Uses

Chromone complex which blocks mast cell degranulation

Indications

Cromolyn sodium (Intal) is chemically related drugs called chromones that is used for the prophylaxis of mild or moderate asthma. It is administered by inhalation and has very good safety profiles, making them particularly useful in treating children.

Definition

ChEBI: An organic sodium salt that is the disodium salt of cromoglycic acid.

General Description

Cromolyn sodium, disodium 1,3-bis(2-carboxychromon-5-yloxy)-2-hydroxypropane (Intal), isa hygroscopic, white, hydrated crystalline powder that is solublein water (1:10). It is tasteless at first but leaves a veryslightly bitter aftertaste. The pK of cromolyn is 2. It is availableas a solution for a nebulizer, an aerosol spray, a nasal solution,an ophthalmic solution, and an oral concentrate.
Nebulized and aerosol cromolyn has been used for prophylacticmanagement of bronchial asthma and prevention ofexercise-induced bronchospasm. Cromolyn nasal solution isused for the prevention and treatment of allergic rhinitis, andoral concentrate is used to treat the histaminic symptomsof mastocytosis (diarrhea, flushing, headaches, vomiting, urticaria,abdominal pain, nausea, and itching). Topical cromolyn(eye drops) is used to treat allergic conjunctivitis andkeratitis. In the treatment of asthma, cromolyn efficacy is manifestedby decreased severity of clinical symptoms, or need for concomitant therapy, or both. Long-term use is justified if thedrug significantly reduces the severity of asthma symptoms;permits a significant reduction in, or elimination of, steroiddosage; or improves management of those who have intolerableside effects to sympathomimetic agents or methylxanthines.For cromolyn to be effective, it must be administered atleast 30 minutes prior to antigen challenge and administered atregular intervals (see dosing information that follows). Wheninhaled, the powder does produce irritation in some patients.Also, overuse of cromolyn can result in tolerance.

Mechanism of action

The precise mechanism or mechanisms whereby cromolyn sodium and nedocromil sodium exert their antiasthmatic activities is unknown. Early work suggested that these agents act by “stabilizing” mast cells, preventing mediator release. However, several other compounds exhibit greater potency for stabilization of mast cells yet possess no clinical efficacy in asthma.This suggests that the therapeutic activity of cromolyn sodium and nedocromil sodium in asthma is related to one or more other pharmacological mechanisms. Postulates include inhibitory effects on irritant receptors, nerves, plasma exudation, and inflammatory cells in general.

Clinical Use

Cromolyn sodium is used almost exclusively for the prophylactic treatment of mild to moderate asthma and should not be used for the control of acute bronchospasm. This agent is effective in about 60 to 70% of children and adolescents with asthma. Unfortunately, there is no reliable means to predict which patients will respond.It is less effective in older patients and in patients with severe asthma. It may take up to 4 to 6 weeks of treatment for cromolyn sodium to be effective in chronic asthma, but it is effective after a single dose in exercise-induced asthma. With respect to clinical efficacy, cromolyn sodium and nedocromil sodium do not differ in a substantial way.

Side effects

Cromolyn sodium is the least toxic of available therapies for asthma. Adverse reactions are rare and generally minor. Those occurring in fewer than 1 in 10,000 patients include transient bronchospasm, cough or wheezing, dryness of throat, laryngeal edema, swollen parotid gland, angioedema, joint swelling and pain, dizziness, dysuria, nausea, headache, nasal congestion, rash, and urticaria.

Cromolyn Disodium Salt Preparation Products And Raw materials

Raw materials

Preparation Products


Cromolyn Disodium Salt Suppliers

Global( 195)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21707 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 493 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 308 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8921 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58

View Lastest Price from Cromolyn Disodium Salt manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-17 Sodium cromoglycate
15826-37-6
US $1.00 / kg 1kg 99.99% Customized career henan chemical co

Cromolyn Disodium Salt Spectrum


15826-37-6(Cromolyn Disodium Salt)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved