4,4'-Dimethoxytrityl chloride
- CAS No.
- 40615-36-9
- Chemical Name:
- 4,4'-Dimethoxytrityl chloride
- Synonyms
- DMT;DMT-CL;4,4'-(Chloro(phenyl)Methylene)bis(Methoxybenzene);4,4-DIMETHOXYTRITYL CHLORIDE;Dimethoxy Trityl Chloride;EPB49;DMTrCl;DMT-Cl)D;DMTRT-CL;NSC 89782
- CBNumber:
- CB3442487
- Molecular Formula:
- C21H19ClO2
- Molecular Weight:
- 338.83
- MDL Number:
- MFCD00008409
- MOL File:
- 40615-36-9.mol
| Product description | Number | Pack Size | Price |
| 4,4′-Dimethoxytrityl chloride 95% | 100013 | 5g | $63.8 |
| 4,4′-Dimethoxytrityl chloride 95% | 100013 | 25g | $178 |
| 4,4'-Dimethoxytrityl Chloride [Hydroxyl Protecting Agent] >97.0%(HPLC)(T) | D1612 | 5g | $42 |
| 4,4'-Dimethoxytrityl Chloride [Hydroxyl Protecting Agent] >97.0%(HPLC)(T) | D1612 | 25g | $122 |
| 4,4′-Dimethoxytriphenylmethyl chloride ≥97.0% (HPLC) | 38827 | 10g | $118 |
| More product size | |||
| Melting point | 123-125 °C |
|---|---|
| Boiling point | 455.07°C (rough estimate) |
| Density | 1.0887 (rough estimate) |
| vapor pressure | 0Pa at 20℃ |
| refractive index | 1.5330 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Powder |
| color | Pink |
| Water Solubility | Soluble in chloroform and methanol. Partially soluble in water |
| Sensitive | Moisture Sensitive |
| BRN | 2471942 |
| Stability | Hygroscopic, Moisture Sensitive |
| InChIKey | JBWYRBLDOOOJEU-UHFFFAOYSA-N |
| LogP | 5.74 at 20℃ |
| CAS DataBase Reference | 40615-36-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Methane, chlorobis(p-methoxyphenyl)phenyl-(40615-36-9) |
| UNSPSC Code | 12352101 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H317-H335-H411 | |||||||||
| Precautionary statements | P260-P271-P273-P280-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-34 | |||||||||
| Safety Statements | 22-24/25-37/39-26-36-45-36/37/39 | |||||||||
| RIDADR | 3261 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| HS Code | 29093090 | |||||||||
| Toxicity | A hallucinogenic (psychedelic) agent that may catalyze the onset of emotional problems or psychosis in predisposed individuals. DMT is perhaps one of the least studied of the hallucinogens. It causes perceptual alterations and illusions, including changes in touch, taste, and odor. The thinking process is substantially altered; there are hallucinations and loss of contact with reality. There have been no overdose deaths attributed to the direct effects of DMT. The drug is very short-acting, with a duration of effect of about half an hour or less. | |||||||||
| NFPA 704 |
|
4,4'-Dimethoxytrityl chloride price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 100013 | 4,4′-Dimethoxytrityl chloride 95% | 40615-36-9 | 5g | $63.8 | 2025-07-31 | Buy |
| Sigma-Aldrich | 100013 | 4,4′-Dimethoxytrityl chloride 95% | 40615-36-9 | 25g | $178 | 2025-07-31 | Buy |
| TCI Chemical | D1612 | 4,4'-Dimethoxytrityl Chloride [Hydroxyl Protecting Agent] >97.0%(HPLC)(T) | 40615-36-9 | 5g | $42 | 2025-07-31 | Buy |
| TCI Chemical | D1612 | 4,4'-Dimethoxytrityl Chloride [Hydroxyl Protecting Agent] >97.0%(HPLC)(T) | 40615-36-9 | 25g | $122 | 2025-07-31 | Buy |
| Sigma-Aldrich | 38827 | 4,4′-Dimethoxytriphenylmethyl chloride ≥97.0% (HPLC) | 40615-36-9 | 10g | $118 | 2025-07-31 | Buy |
4,4'-Dimethoxytrityl chloride Chemical Properties,Uses,Production
Chemical Properties
4,4'-Dimethoxytrityl chloride is pink powder
Uses
4,4'-Dimethoxytrityl chloride is a versatile protecting group for primary alcohols, specially useful in oligonucleotide synthesis
Uses
4,4'-Dimethoxytrityl chloride is used as a protective reagent for oligonucleotide synthesis. It is used for selective protection and deprotection procedures for thiol and hydroxy groups in nucleoside derivatives.
Uses
Hydroxyl protecting group for nucleosides and nucleotides.
Flammability and Explosibility
Not classified
Synthesis
100-66-3
98-07-7
40615-36-9
a. In a 500 L reactor, 75 kg of trichloromethylbenzene (M = 195.48, n = 383.67 mol) and 103.72 kg of anisole (M = 108.14, n = 959.17 mol) were added, followed by the addition of 53.35 kg of the catalyst aluminum chloride (M = 133.34, n = 400.1 mol). The reaction temperature was controlled to be 30 °C and the reaction was continuously stirred for 10 h to obtain the mixed reaction solution I. b. Add 475 kg of 5% dilute hydrochloric acid to the mixed reaction solution I at 30°C and transfer to a 1000 L reactor for hydrolysis reaction for 3 hours. Subsequently, 200 kg of dichloromethane was added, stirred well and stratified. After separating the organic phase, the aqueous phase was extracted twice with 200kg of dichloromethane. All organic phases were combined and dried with anhydrous sodium sulfate for 2 hours. c. Concentrate the dichloromethane to recover the solvent. 70.74 kg of epichlorohydrin (M = 126.93, n = 557.32 mol) was added and the reaction was carried out under reflux for 6 hours. After completion of the reaction, 130 kg of petroleum ether was added dropwise and cooled to 30°C for crystallization. Crude 4,4'-dimethoxytrityl chloride (DMT-Cl) was obtained by solid-liquid separation, and the HPLC purity of the crude product was 98.91%. d. The crude DMT-Cl was recrystallized with 4.5 times mass of dichloromethane and 20 times mass of petroleum ether, and the wet product was obtained by solid-liquid separation. The wet product was dried to give a final product DMT-Cl 110.66 kg with a purity of 99.95% and a yield of 85.13%. The recovered mixed solvent was quantitatively analyzed by gas chromatography (GC) and recycled.
Purification Methods
DMT crystallises from cyclohexane/acetyl chloride as the hydrochloride. Dry it over KOH pellets in a desiccator. When dissolved in *C6H6 and air is blown through, HCl is removed. It crystallises from Et2O. [Baeyer & Villiger Chem Ber 36 2788 1903, Smith et al. J Am Chem Soc 84 430 1962, Smith et al. J Am Chem Soc 85 3821 1963.] Ifit has hydrolysed considerably (see OH in IR), then repeat the crystallisation from cyclohexane/acetyl chloride — excess of AcCl is removed in a vacuum over KOH, then recrystallise it from Et2O. [Beilstein 6 IV 1042.]
References
[1] Patent: CN107056590, 2017, A. Location in patent: Paragraph 0022; 0023; 0024; 0025; 0026; 0027; 0028-0045
4,4'-Dimethoxytrityl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Highfine Biotech Co.,Ltd. | +86-0512-68071238 +86-13771819922 | june@highfine.com | China | 458 | 58 |
| INNOBIO PHARM CO.,LTD | +8615600141006 | cindyyb@126.com | China | 279 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8460 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5249 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20135 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13595 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21612 | 55 |
View Lastest Price from 4,4'-Dimethoxytrityl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-11 | 4,4'-Dimethoxytrityl chloride
40615-36-9
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2025-12-11 | 4,4'-Dimethoxytrityl chloride
40615-36-9
|
US $128.00 / kg | 1kg | 0.99 | 25kg | Shanghai UCHEM Inc. | |
 |
2025-12-01 | 4,4'-Dimethoxytrityl chloride
40615-36-9
|
US $0.00 / kg | 1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 4,4'-Dimethoxytrityl chloride
40615-36-9
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 4,4'-Dimethoxytrityl chloride
40615-36-9
- US $128.00 / kg
- 0.99
- Shanghai UCHEM Inc.
-
- 4,4'-Dimethoxytrityl chloride
40615-36-9
- US $0.00 / kg
- 99%
- Shaanxi Dideu New Materials Co. Ltd
