SW203668 (trifluoroacetate salt)
- CAS No.
- 2117405-48-6
- Chemical Name:
- SW203668 (trifluoroacetate salt)
- Synonyms
- SW203668 (trifluoroacetate salt);SW203668 (trifluoroacetate salt),SW-203668 (trifluoroacetate salt);4-(aminophenylmethyl)-N-(6-methoxy-2-benzothiazolyl)-benzamide,trifluoroacetatesalt
- CBNumber:
- CB34815298
- Molecular Formula:
- C24H20F3N3O4S
- Molecular Weight:
- 503.5
- MDL Number:
- MFCD30480921
- MOL File:
- 2117405-48-6.mol
| Product description | Number | Pack Size | Price |
| SW203668 (trifluoroacetate salt) | 19379 | 1mg | $37 |
| SW203668 (trifluoroacetate salt) | 19379 | 5mg | $116 |
| SW203668 (trifluoroacetate salt) | 19379 | 10mg | $213 |
| 4-[Amino(phenyl)methyl]-N-(6-methoxy-1,3-benzothiazol-2-yl)benzamide;2,2,2-trifluoroaceticacid | 4637EH | 5mg | $226 |
SW203668 (trifluoroacetate salt) price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19379 | SW203668 (trifluoroacetate salt) | 2117405-48-6 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 19379 | SW203668 (trifluoroacetate salt) | 2117405-48-6 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 19379 | SW203668 (trifluoroacetate salt) | 2117405-48-6 | 10mg | $213 | 2024-03-01 | Buy |
| AK Scientific | 4637EH | 4-[Amino(phenyl)methyl]-N-(6-methoxy-1,3-benzothiazol-2-yl)benzamide;2,2,2-trifluoroaceticacid | 2117405-48-6 | 5mg | $226 | 2021-12-16 | Buy |
SW203668 (trifluoroacetate salt) Chemical Properties,Uses,Production
Description
SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines that express cytochrome P450 (CYP) isoform CYP4F11 over eight other cancer cell lines that lack CYP4F11 in vitro (IC50s = 22-116 and >10,000 nM, respectively) and ectopic expression of CYP4F11 in SW203668-insensitive H1155 cells results in sensitization to SW203668. In vivo, SW203668 reduces tumor growth rate without reducing sebocyte production in the H2122 wild-type and nonobese diabetic severe combined immunodeficiency (NOD-SCID) mouse xenograft models when administered at doses of 20 and 6 mg/kg, respectively.
Uses
SW203668 TFA is a benzothiazole compound, shows anti-tumor activity against lung cancer cell lines (IC50=0.022-0.116 μM)
References
[1] Theodoropoulos PC, et al. Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase. Nat Chem Biol. 2016 Apr;12(4):218-25. DOI:10.1038/nchembio.2016
SW203668 (trifluoroacetate salt) Preparation Products And Raw materials
Raw materials
Preparation Products
SW203668 (trifluoroacetate salt) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29641 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
| Foshan Minghua Biotechnology Co., Ltd. | 18312287787 | CHINA | 196 | 58 |
View Lastest Price from SW203668 (trifluoroacetate salt) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-07-29 | SW203668 (trifluoroacetate salt)
2117405-48-6
|
US $0.00-0.00 / mg | 10g | TargetMol Chemicals Inc. |
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- SW203668 (trifluoroacetate salt)
2117405-48-6
- US $0.00-0.00 / mg
- TargetMol Chemicals Inc.
