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Nicotinamide riboside

Nicotinamide riboside
Nicotinamide riboside structure
CAS No.
1341-23-7
Chemical Name:
Nicotinamide riboside
Synonyms
C:C&B64;Niacinamide Ribose;Nicotinamide Ribose;Nicotiamide Riboside;NICOTINAMIDE RIBOSIDE;N-ribosylnicotinamide;Nicotinimide Riboside;Nicotinamide Ribose NR;β-Nicotinamide Riboside;BETA-nicotinamide ribose
CBNumber:
CB3501487
Molecular Formula:
C11H16N2O5
Formula Weight:
256.26
MOL File:
1341-23-7.mol

Nicotinamide riboside Properties

FDA UNII
0I8H2M0L7N
NCI Drug Dictionary
nicotinamide riboside

Nicotinamide riboside price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 23132 Nicotinamide riboside ≥95% 1341-23-7 1mg $28 2021-03-22 Buy
Cayman Chemical 23132 Nicotinamide riboside ≥95% 1341-23-7 5mg $126 2021-03-22 Buy
Cayman Chemical 23132 Nicotinamide riboside ≥95% 1341-23-7 10mg $224 2021-03-22 Buy
Cayman Chemical 23132 Nicotinamide riboside ≥95% 1341-23-7 25mg $490 2021-03-22 Buy

Nicotinamide riboside Chemical Properties,Uses,Production

Description

Nicotinamide Riboside (NR) is a next-generation vitamin B3 that has been found to be naturally-occurring in milk in trace amounts. The metabolism of NR is unique from that of other more commonly known forms of vitamin B3 , nicotinamide and nicotinic acid. Specifically, NR has been shown in a pre-clinical study to be the most effective form of vitamin B3 at increasing nicotinamide adenine dinucleotide (NAD+)2 .
Nicotinic acid (also known as niacin) and nicotinamide (also known as niacinamide) were discovered in the 1930’s to be the factors that cured pellagra . Niacin is known to cause severe flushing . In 2004, nicotinamide riboside emerged as a newly discovered NAD+ precursor and does not bind to the receptor responsible for flushing.
NR has pre-clinically demonstrated that it is superior to both niacin and nicotinamide, both of which are standard forms of vitamin B3 commonly used in vitamin supplements and foods, at boosting NAD+2 . This is due to the fact that NR is not reliant upon a conversion step requiring the enzyme “NAMPT” , see Figure below. The activity level of NAMPT determines the amount of nicotinamide that is converted into NAD+ , which is why this particular step in the process is often referred to as the “rate limiting step”. As normal aging occurs, the activity of NAMPT is thought to decrease. NR can be used by the cell to make NAD+ without this enzymatic step.
NAD+ synthesis from nicotinic acid, nicotinamide, and nicotinamide riboside
NAD+ synthesis from nicotinic acid, nicotinamide, and nicotinamide riboside

Chemical Properties

Nicotinamide riboside (NR) is part of the B3 vitamin family. Like other forms of vitamin B3, nicotinamide riboside gets converted into nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for life. For this reason, it is often called a NAD+ precursor because it is part of the series of chemical steps that are required to create NAD+.
Different biosynthetic pathways are responsible for converting the different B3 vitamins into NAD+. The enzyme nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step of the two-step pathway converting nicotinamide to NAD+. NR kinase enzymes can also function as a salvage pathway for NAD+, but this pathway is not essential.

Definition

ChEBI: A pyridine nucleoside consisting of nicotinamide with a beta-D-ribofuranosyl moiety at the 1-position.

Biological Functions

Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme that, when reduced to NADH, serves as a reducing agent to donate electrons for oxidative phosphorylation and ATP synthesis in mitochondria. NAD+ is a critical cofactor for enzymes such as sirtuins, ADP-ribosyltransferases (ARTs), and Poly [ADP- ribose] polymerases (PARPs) and is continuously consumed by these enzymes. The NAD+/NADH ratio is a critical component of the redox state of the cell. (Verdin 2015). By some counts, NAD or the related NADP participates in a quarter of all cellular reactions (Opitz Heiland 2015). There are separate compartments of NAD+ in the nucleus, mitochondria, and cytoplasm (Verdin 2015).
Nicotinamide riboside (NR) can be converted into NAD+ through an intermediate step in which it is converted into nicotinamide mononucleotide (NMN) by NR kinase (Nrk) and then to NAD+ by NMNATs. NR is naturally found in some foods but at very low quantities (e.g. low micromolar range). Historically, NR was difficult to obtain in large purified amounts, but thanks to advances in synthesis methods (Yang 2007), as of June 2013, it is sold as a dietary supplement.

Clinical Use

Nicotinamide riboside is important because it is a potent and bioavailable pre-cursor to NAD+. NAD+ is essential to life and is known to be vital to functions that ensure proper cellular and energy metabolism. The most well-known function of NAD+ is the transferring of electrons to the machinery in the cell that produces ATP, the energy currency of all cells.
NAD+ is increasingly being shown to have important functions beyond electron transfer. One of the most promising potential roles for NR as a pre-cursor to NAD+ is activation of sirtuins, enzymes associated with a wide variety of functions related to metabolism and longevity.

Side effects

No serious adverse effects have been reported in human studies, though most of the studies so far have been short in duration and low in participant numbers. The need for larger scale and more robust human studies is critical if NR is to be properly evaluated.
To date, some people have reported mild to moderate side effects, including nausea, fatigue, headaches, diarrhea, stomach upset and indigestion. While that seems to suggest NR is likely safe, the lack of large scale long-term studies means that this cannot be confirmed.
As always, if you do decide to take a NR supplement and experience any adverse effects, you should cease taking it immediately and consult your doctor.

Safety

Nicotinamide riboside has a successful New Dietary Ingredient Notification with FDA (NDIN 882) for daily recommended intake of not more than 180 mg/d.
Nicotinamide riboside is generally recognized as safe (FDA GRAS Notice No. 635) for use in vitamin waters, protein shakes, nutrition bars, gum, chews, and powdered beverages. Maximum use level 0.0057% by weight.

Mode of action

NAD+ is a critical and often rate-limiting factor in many aspects of mitochondrial and cellular function including DNA repair by PARPs, widespread acetylation and epigenetic effects by sirtuins, efficient production of ATP, and other pathways (Stein & Imai 2012). NAD+ levels decline with age as does the ratio of NAD+/NADH, with numerous studies suggesting that blunting this decline with NAD+ precursors or genetic manipulations can blunt fundamental features of aging (see below). The levels also decline with the high-fat diet but increase with calorie restriction and fasting (Stein & Imai 2012), leading some to argue that it can function as a calorie restriction mimetic.
www.alzdiscovery.org

Nicotinamide riboside Preparation Products And Raw materials

Raw materials

Preparation Products


Nicotinamide riboside Suppliers

Global( 263)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai UCHEM Inc.
15502138767 15502138767
sales@myuchem.com CHINA 2773 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 310 58
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1009 58
Effepharm (Shanghai) Co., Ltd
15721516694
phoebe@effepharm.com CHINA 9 58
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037
info@konochemical.com CHINA 3000 58
Shandong Hengshannuode Pharmaceutical Technology Co., Ltd.
13583348585
admin@hsnordpharma.com CHINA 92 58
Xi'an MC Biotech, Co., Ltd.
18991951683 02989275612
8618991951683 mcbio_sales@163.com CHINA 2308 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20918 58

View Lastest Price from Nicotinamide riboside manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-26 NICOTINAMIDE RIBOSIDE
1341-23-7
US $10.00 / KG 1KG 99.9% 20tons/month Shanxi Lianxu New Material Co., LTD
2021-11-26 Nicotinamide Riboside
1341-23-7
US $64.00 / KG 1KG 99% 100kg Hong Kong Tiansheng New Material Trading Co., Ltd
2021-11-26 NICOTINAMIDE RIBOSIDE
1341-23-7
US $1984.00 / Kg/Bag 1KG 99% 1t Baoji Guokang Bio-Technology Co., Ltd.

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