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BAFILOMYCIN A1

BAFILOMYCIN A1 Structure
BAFILOMYCIN A1 structure
CAS No.
88899-55-2
Chemical Name:
BAFILOMYCIN A1
Synonyms
CS-1163;afilomycin A1;BAFILOMYCIN A1;Bafilomycin A1,95%;BAFILOMYCIN A1 95%;BAFILOMYCIN A1, 98+%;Bafilomycin A1(Baf-A1);BAFILOMYCIN A1 USP/EP/BP;BafilomycinA1fromStreptomycesgriseus;BAFILOMYCIN A1, STREPTOMYCES GRISEUS
CBNumber:
CB3743951
Molecular Formula:
C35H58O9
Molecular Weight:
622.83
MDL Number:
MFCD06795130
MOL File:
88899-55-2.mol
Last updated:2023-09-20 16:43:00
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BAFILOMYCIN A1 Properties

Melting point >106°C (dec.)
Boiling point 582.86°C (rough estimate)
Density 1.0594 (rough estimate)
refractive index 1.5000 (estimate)
RTECS RN9781000
Flash point 87℃
storage temp. -20°C
solubility Soluble in DMSO (up to 5 mg/ml, with warming).
pka 12.66±0.70(Predicted)
form Powder or Solid
color White to off-white
Water Solubility Soluble in methanol, ethanol, acetone and chloroform. Insoluble in water.
BRN 4730700
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335-H227
Precautionary statements  P210e-P280a-P370+P378a-P403+P235-P501a-P261-P304+P340-P305+P351+P338-P405
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  3172
WGK Germany  3
F  10
HazardClass  6.1(b)
PackingGroup  III
HS Code  29419090
NFPA 704
0
2 0

BAFILOMYCIN A1 price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B1793 Bafilomycin A1 from Streptomyces griseus ≥90% (HPLC) 88899-55-2 2μg $86.8 2024-03-01 Buy
Sigma-Aldrich SML1661 Bafilomycin A1 Ready Made Solution 0.16?mMinDMSO,fromStreptomycesgriseus 88899-55-2 0.1ml $220 2024-03-01 Buy
Sigma-Aldrich B1793 Bafilomycin A1 from Streptomyces griseus ≥90% (HPLC) 88899-55-2 10μg $210 2024-03-01 Buy
Sigma-Aldrich 5.08409 InSolution Bafilomycin A1, ≥97% by HPLC - CAS 88899-55-2 - Calbiochem A 100 μM (15 μg/241 μL) sterile-filtered solution of Bafilomycin A1, 88899-55-2 15μG $280 2024-03-01 Buy
Sigma-Aldrich 196000 Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem Bafilomycin A1, CAS 88899-55-2, acts as a highly potent and specific inhibitor of vacuolar-type H+-ATPase (Ki = 500 pM). Blocks the fusion of autophagosome with lysosome. 88899-55-2 10μG $201 2024-03-01 Buy
Product number Packaging Price Buy
B1793 2μg $86.8 Buy
SML1661 0.1ml $220 Buy
B1793 10μg $210 Buy
5.08409 15μG $280 Buy
196000 10μG $201 Buy

BAFILOMYCIN A1 Chemical Properties,Uses,Production

Description

Bafilomycin A1 is a fungal metabolite that has been found in Streptomyces and has diverse biological activities. It is an inhibitor of vacuolar H+-ATPases (V-ATPases; Ki = 0.5 nM in N. crassa vacuolar membranes) and is greater than 1,000-fold selective for V-ATPases over Na+/K+-, Ca2+-, and H+-ATPases. Bafilomycin A1 (100 nM) inhibits autophagosome maturation and protein degradation in H-4-II-E cells. It inhibits chloroquine-induced apoptosis in primary cerebellar granule neurons (CGNs) but not chloroquine-induced inhibition of macroautophagy. Bafilomycin A1 (100 nM) reduces viral yield in the culture supernatant of Vero E6 and Huh7 cells, as well as HEK293T cells expressing human angiotensin-converting enzyme 2 (ACE2), infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It also reduces lung RNA copy numbers and viral pneumonia in ACE2 transgenic mice infected with SARS-CoV-2 when administered at a dose of 0.1 mg/kg.

Chemical Properties

white to off-white powder

Uses

A macrolide antibiotic and potent and selective inhibitor of vacuolar-type (v-type) H+ ATPase

Uses

Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases.It is used as an antibacterial, antifungal, antineoplastic and an immunosuppressive. It prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes and is a macrolide antibiotic and potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase).

Uses

Bafilomycin A1 is a member of a potent family of macrocyclic lactones with broad spectrum biological activity, including activity against bacteria, yeast, fungi, nematodes, insects and tumour cell lines. Bafilomycin A1 is an inhibitor of vacuolar-type ATPase.

Definition

ChEBI: The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus.

General Description

A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution format with a purity of ≥97% by HPLC in 90% DMSO is also available (Cat. No. 508409).

Biological Activity

Highly potent, selective inhibitor of vacuolar H + -ATPases (IC 50 = 500 pM as measured in chromaffin granule membranes). Selective over other ATP hydrolyzing enzymes such as F-ATPases, Ca 2+ -ATPases, Na + /K + -ATPases and plasma membrane H + -ATPases.

Biochem/physiol Actions

Bafilomycin A1 is a macrolide antibiotic. Bafilomycin A1 acts as a potent and selective inhibitor of vacuolar-type H+-ATPase.

storage

-20°C

References

1) Werner?et al.? (1984) Metabolic products of microorganisms. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity; J. Antibiot.,?37?110 2) Drose and Altendorf? (1997)?Bafilomycins and concanamycins as inhibitors of V-ATPase and P-ATPase;?J. Exp. Biol.,?200?1 3) Yamamoto?et al. (1998)?Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells;?Cell Struct. Func.,?23?33

BAFILOMYCIN A1 Preparation Products And Raw materials

Raw materials

Preparation Products

BAFILOMYCIN A1 Suppliers

Global( 211)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9341 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shaanxi Dideu Medichem Co. Ltd 		18192627656 1012@dideu.com China 2409 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 28098 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19915 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Supplier Advantage
Hangzhou FandaChem Co.,Ltd. 		55
career henan chemical co 		58
Biochempartner 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Nextpeptide Inc 		58
InvivoChem 		58

View Lastest Price from BAFILOMYCIN A1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BAFILOMYCIN A1 USP/EP/BP pictures 2021-07-17 BAFILOMYCIN A1 USP/EP/BP
88899-55-2
 US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
BafiloMycin A1 pictures 2020-05-09 BafiloMycin A1
88899-55-2
 US $0.01-1.00 / KG 25KG 99%min 20 tons Shaanxi Dideu Medichem Co. Ltd
BAFILOMYCIN A1 pictures 2019-07-06 BAFILOMYCIN A1
88899-55-2
 US $1.00 / kg 1kg 95%-99% 100kg Career Henan Chemical Co
  • BafiloMycin A1 pictures
  • BafiloMycin A1
    88899-55-2
  • US $0.01-1.00 / KG
  • 99%min
  • Shaanxi Dideu Medichem Co. Ltd

BAFILOMYCIN A1 Spectrum

BAFILOMYCIN A1(88899-55-2)1HNMR

88899-55-2(BAFILOMYCIN A1)Related Search:

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BAFILOMYCIN B2 FROM STREPTOMYCES GRISEUS BAFILOMYCIN B1 MONOHYDRATE Bafilomycin D2' Bafilomycin E Bafilomycin D1
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Bafilomycin A1 Bafilomycin A1 from Streptomyces griseus Bafilomycin A1(Baf-A1) BAFILOMYCIN A1 BAFILOMYCIN A1, STREPTOMYCES GRISEUS BAFILOMYCIN A1, 98+% BAFILOMYCIN A1 95% (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-((1S,2R,3S)-2-hydroxy-1-methyl-3-((2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5 BafilomycinA1fromStreptomycesgriseus 21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-hygrolidin Bafilomycin A1,95% (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-Methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-Methyl-6-(1-Methylethyl)-2H-pyran-2-yl]butyl]-3,15-diMethoxy-5,7,9,11-tetraMethyloxacyclohexadeca-3,5,11,13-tetraen-2-o Bafilomycin A1 from Streptomycesgriseus, 10 ug Bafilomycin A1, 95%, from Streptomyces griseus CS-1163 Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem Oxacyclohexadeca-3,5,11,13-tetraen-2-one, 8-hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyl-, (3Z,5E,7R,8S,9S,11E,13E,15S,16R)- BafilomycinBafilomycin A1Bafilomycin A1, from Streptomyces griseus BAFILOMYCIN A1 USP/EP/BP (3Z,5Z,7R,8S,9S,11E,13E,15S,16R)-16-((2S,3R,4S)-4-((2R,4R,5S,6R)-2,4-Dihydroxy-6-isopropyl-5-methyltetrahydro-2H-pyran-2-yl)-3-hydroxypentan-2-yl)-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one afilomycin A1 88899-55-2 C35H58O9 Antibiotics A-F Antibiotics A to Z Antibiotics BioChemical antibiotic A - KAntibiotics Antibacterial Antibiotics A to Antibiotics A-FAntibiotics Antibiotics by Application AntifungalAntibiotics Antineoplastic and Immunosuppressive AntibioticsAntibiotics Chemical Structure Class Inhibits an EnzymeAntibiotics MacrolidesMore...Close... Mechanism of Action Spectrum of Activity Peptide Synthesis/Antibiotics