2-Cyano-3-methyl-5-nitropyridine
- CAS No.
- 65169-63-3
- Chemical Name:
- 2-Cyano-3-methyl-5-nitropyridine
- Synonyms
- 3-Methyl-5-nitropicolinonitrile;3-Cyano-2-Methyl-5-nitropyridine;2-Cyano-3-methyl-5-nitropyridine;3-methyl-5-nitro-2-Pyridinecarbonitrile;2-Pyridinecarbonitrile, 3-methyl-5-nitro-
- CBNumber:
- CB41471128
- Molecular Formula:
- C7H5N3O2
- Molecular Weight:
- 163.13
- MDL Number:
- MFCD07375120
- MOL File:
- 65169-63-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P261-P271 |
| HS Code | 2933399990 |
2-Cyano-3-methyl-5-nitropyridine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| SynQuest Laboratories | 4H54-1-F7 | 2-Cyano-3-methyl-5-nitropyridine 98% | 65169-63-3 | 1g | $90 | 2021-12-16 | Buy |
| Matrix Scientific | 153083 | 3-Methyl-5-nitropicolinonitrile 95% | 65169-63-3 | 1g | $296 | 2021-12-16 | Buy |
| AK Scientific | Y5001 | 2-Cyano-3-methyl-5-nitropyridine | 65169-63-3 | 250mg | $45 | 2021-12-16 | Buy |
| AK Scientific | Y5001 | 2-Cyano-3-methyl-5-nitropyridine | 65169-63-3 | 10g | $481 | 2021-12-16 | Buy |
| AK Scientific | J96781 | 2-Cyano-3-methyl-5-nitropyridine | 65169-63-3 | 25g | $750 | 2021-12-16 | Buy |
2-Cyano-3-methyl-5-nitropyridine Chemical Properties,Uses,Production
Synthesis
20970-75-6
65169-63-3
The general procedure for the synthesis of 2-cyano-3-methyl-5-nitropyridine from 2-cyano-3-methylpyridine was as follows: 3-methylpyridine-2-carbonitrile (128 g, 1.08 mol) and tetrabutylammonium nitrate (363 g, 1.19 mol) were dissolved in tertiary-butylmethyl ether (1.3 L) and the mixture was cooled down to 4 °C. Trifluoroacetic anhydride (171 mL, 1.21 mol) was slowly added under stirring, followed by continuous stirring of the reaction mixture for 60 hours at room temperature. Upon completion of the reaction, the pH of the mixture was adjusted to about 7 with 20% aqueous sodium hydroxide solution and then extracted with dichloromethane (3 x 1 L). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Purification of the crude product by silica gel column chromatography (elution gradient: 0% to 10% petroleum ether solution of ethyl acetate) afforded the target compound 2-cyano-3-methyl-5-nitropyridine as a yellow solid. Yield: 70 g, 0.43 mmol, 40% yield.1H NMR (400 MHz, CDCl3) δ 9.31-9.36 (m, 1H), 8.47-8.52 (m, 1H), 2.74 (s, 3H).
References
[1] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 9, p. 1845 - 1855
[2] Patent: WO2015/155626, 2015, A1. Location in patent: Page/Page column 89; 90
[3] Patent: WO2017/51294, 2017, A1. Location in patent: Page/Page column 57; 58
[4] Patent: WO2017/51303, 2017, A1. Location in patent: Page/Page column 72; 73
[5] Patent: WO2017/51276, 2017, A1. Location in patent: Page/Page column 99
2-Cyano-3-methyl-5-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29804 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53900 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30123 | 84 |
| Shanghai AmasPharm Co., Ltd. | 021-54540637 18621091017 | sales@amaspharm.com | China | 762 | 62 |
| ZhengZhou HuaWen Chemical Co.Ltd | 0370-2785118 17550508557 | 675141927@qq.com | China | 3202 | 55 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9891 | 58 | |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8878 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 17798518460 | cfzhang@aikonchem.com | China | 19913 | 55 |
View Lastest Price from 2-Cyano-3-methyl-5-nitropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | 2-Cyano-3-methyl-5-nitropyridine
65169-63-3
|
US $5.00 / KG | 1KG | 98% | 100KG | Career Henan Chemical Co |
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- 2-Cyano-3-methyl-5-nitropyridine
65169-63-3
- US $5.00 / KG
- 98%
- Career Henan Chemical Co