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Midazolam hydrochloride

CAS No.
59467-96-8
Chemical Name:
Midazolam hydrochloride
Synonyms
rocam;versed;hypnovel;ro21-3981/003;MIDAZOLAM HCL;MIDAZOLAM HYDROCHLORIDE;Midazolam hydrochloride USP/EP/BP;Midazolam Hydrochloride CIV (200 mg);Midazolam Hydrochloride CIV (200 mg) (AS);MIDAZOLAM HYDROCHLORIDE, DEA SCHEDULE III
CBNumber:
CB4174637
Molecular Formula:
C18H14Cl2FN3
Molecular Weight:
362.23
MDL Number:
MFCD01721980
MOL File:
59467-96-8.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

Midazolam hydrochloride Properties

storage temp. 2-8°C
Water Solubility Soluble to 25 mM in water
NCI Dictionary of Cancer Terms midazolam hydrochloride; Versed
FDA UNII W7TTW573JJ
NCI Drug Dictionary midazolam hydrochloride
Proposition 65 List Midazolam Hydrochloride
EPA Substance Registry System Midazolam hydrochloride (59467-96-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
Hazard statements  H336-H362-H302-H361
Precautionary statements  P261-P271-P304+P340-P312-P403+P233-P405-P501-P264-P270-P301+P312-P330-P501-P201-P260-P263-P264-P270-P308+P313-P201-P202-P281-P308+P313-P405-P501
RIDADR  3249
RTECS  NI2922250
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933910000

Midazolam hydrochloride Chemical Properties,Uses,Production

Uses

Anti-Spasmodic

Uses

Midazolam Hydrochloride is a sensitive CYP 3A4 probe substrate.

Definition

ChEBI: Midazolam hydrochloride is the hydrochloride salt of midazolam. It has a role as an anticonvulsant, an antineoplastic agent, an anxiolytic drug, an apoptosis inducer, a central nervous system depressant, a GABAA receptor agonist, a general anaesthetic, a muscle relaxant and a sedative. It is an imidazobenzodiazepine and a hydrochloride. It contains a midazolam.

brand name

Versed (Roche).

Biological Activity

Sedative/hypnotic agent that acts at the GABA A receptor benzodiazepine modulatory site.

Veterinary Drugs and Treatments

In veterinary patients, midazolam is used principally as a premedicant for general anesthesia. Alone, it does not appear to provide predictable sedation in animals. Animals may become sedated or dysphoric and excited. Cats may be more prone to develop the “excited” effect more than dogs. When used in combination with other drugs (i.e., opioids or ketamine), midazolam does provide more predictable sedation.
Midazolam may also be of benefit to treat status epilepticus when given either IV or IM (not rectally).
In humans, midazolam has been suggested for use as a premedicant before surgery, and as a conscious sedative when combined with potent analgesic/anesthetic drugs (e.g., ketamine or fentanyl). In humans, midazolam reduces the incidences of “dreamlike” emergence reactions and increases in blood pressure and cardiac rate caused by ketamine.
When compared to the thiobarbiturate induction agents (e.g., thiamylal, thiopental), midazolam has less cardiopulmonary depressant effects, is water-soluble, can be mixed with several other agents, and does not tend to accumulate in the body after repeated doses.

storage

Desiccate at RT

Midazolam hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

8-CHLORO-6-(2-FLUOROPHENYL)-1-METHYL-4H-IMIDAZO[1,5A][1,4]BENZODIAZEPINE HYDROCHLORIDE MIDAZOLAM HCL MIDAZOLAM HYDROCHLORIDE 5-a)(1,4)benzodiazepine,8-chloro-6-(2-fluorophenyl)-1-methyl-4h-imidazo(hy 8-chloro-6-(2-fluorophenyl)-1-methyl-4h-imidazo(1,5-a)(1,4)benzodiazepinehyd hypnovel ro21-3981/003 rocam versed Midazolam Hydrochloride CIV (200 mg) (AS) 8-chloro-6-(2-fluorophenyl)-1-Methyl-4H-iMidazo[1,5-a][1,4]benzodiazepine hydrochloride (1:1) 4H-IMidazo[1,5-a][1,4]benzodiazepine,8-chloro-6-(2-fluorophenyl)-1-Methyl-, hydrochloride (1:1) 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine monohydrochloride MIDAZOLAM HYDROCHLORIDE, DEA SCHEDULE III 4H-Imidazo1,5-a1,4benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-, monohydrochloride Midazolam hydrochloride USP/EP/BP Midazolam HydrochlorideQ: What is Midazolam Hydrochloride Q: What is the CAS Number of Midazolam Hydrochloride Q: What is the storage condition of Midazolam Hydrochloride Midazolam Hydrochloride CIV (200 mg) 59467-96-8 C18H13ClFN3HCl Antibiotics