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1-AdaMantanethylaMine

CAS No.
13392-28-4
Chemical Name:
1-AdaMantanethylaMine
Synonyms
RIMANTADINE;LEVOFLOXACIN HCL;RiMantidine;1-Adamantanemethylamine;RiMantadine (FluMadine);1-Adaman;AKOS B022266;1-Rimantadine;AKOS NCG1-0034;1-Adamantanethylamine
CBNumber:
CB7122907
Molecular Formula:
C12H21N
Molecular Weight:
179.3
MDL Number:
MFCD00869344
MOL File:
13392-28-4.mol
MSDS File:
SDS
Modify Date:2022-11-11 13:01:00

1-AdaMantanethylaMine Properties

Boiling point 248°C
Density 1.033
Flash point 99°C
pka 11.17±0.29(Predicted)
CAS DataBase Reference 13392-28-4(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 0T2EF4JQTU
ATC code J05AC02
NIST Chemistry Reference 1-Adamantanemethylamine, «alpha»-methyl-(13392-28-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
HazardClass  IRRITANT

1-AdaMantanethylaMine price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AK Scientific G879 Rimantadine 13392-28-4 5g $298 2021-12-16 Buy
American Custom Chemicals Corporation API0024288 RIMANTADINE 95.00% 13392-28-4 1G $648.81 2021-12-16 Buy
Biorbyt Ltd orb134362 Rimantadine (Flumadine) >99% 13392-28-4 250mg $765 2021-12-16 Buy
American Custom Chemicals Corporation API0024288 RIMANTADINE 95.00% 13392-28-4 2.5G $852.21 2021-12-16 Buy
Biorbyt Ltd orb134362 Rimantadine (Flumadine) >99% 13392-28-4 100mg $510 2021-12-16 Buy
Product number Packaging Price Buy
G879 5g $298 Buy
API0024288 1G $648.81 Buy
orb134362 250mg $765 Buy
API0024288 2.5G $852.21 Buy
orb134362 100mg $510 Buy

1-AdaMantanethylaMine Chemical Properties,Uses,Production

Description

Rimantadine (Brand name: Flumadine) is a kind of RNA synthesis inhibitor that used as an orally administrated antiviral drug in the prophylaxis and for the treatment of influenza. It is capable of shortening the duration and alleviated the symptoms of influenza. However, it is now not recommended for the treatment of influenza any longer due to the emergence of resistance problem since 2009. Its mechanism of action is not fully understood. It is indicated that it take effects through inhibiting the viral replication through possibly inhibiting the uncoating process of the virus. The virus M2 protein (an ion channel) seems to play an important role in the susceptibility of influenza A virus to the treatment of Rimantadine.

References

https://www.drugbank.ca/drugs/DB00478
https://en.wikipedia.org/wiki/Rimantadine

Uses

Rimantadine act by blocking the M2 ion channel which is required for uptake of protons into the interior of the virus to permit acid-promoted viral uncoating (decapsidation).

brand name

Flumadine (Forest).

General Description

Resistant variants of influenza type A have been recoveredfrom rimantadine-treated patients.Resistance with inhibitory concentrations increased morethan 100-fold have been associated with single nucleotidechanges that lead to amino acid substitutions in the transmembranedomain of M2. rimantadineshare cross-susceptibility and resistance.

Pharmaceutical Applications

An analog of amantadine, supplied as the hydrochloride for oral administration.

Mechanism of action

Rimantadine hydrochloride (α-methyl-1-adamantanemethylamine hydrochloride) is a synthetic adamatane derivative that is structurally and pharmacologically related to amantadine. It appears to be more effective than amantadine hydrochloride against influenza A, with fewer CNS side effects. Rimantadine hydrochloride is thought to interfere with virus uncoating by inhibiting the release of specific proteins. It may act by inhibiting RT or the synthesis of virus-specific RNA, but it does not inhibit virus adsorption or penetration. It appears to produce a virustatic effect early in the virus replication. It is used widely in Russia and Europe.

Pharmacokinetics

Oral absorption: >90%
Cmax 100 mg oral (every 12 h): 0.4–0.5 mg/L after 2–6 h
Plasma half-life: c. 35 h
Volume of distribution: Very large
Plasma protein binding: c. 40%
Absorption and distribution
Single- and multiple-dose pharmacokinetic studies in elderly patients and young adults are remarkably similar. The steadystate concentration in nasal mucus develops by day 5 at a concentration approximately 1.5-fold higher than plasma.
Metabolism
In contrast to amantadine, rimantadine is extensively metabolized in the liver by hydroxylation and glucuronidation.
Excretion
Less than 20% is excreted unchanged in the urine and most of the breakdown products are excreted by this route. Thus, the plasma half-life is much less affected by renal dysfunction than that of amantadine.

Clinical Use

rimantadine is used for the treatment of diseases caused by influenza A strains.

Clinical Use

Prophylaxis and treatment of influenza A H1N1 infections Since prolonged administration is well tolerated by elderly patients, the drug is preferable to amantadine.

Side effects

Rimantadine has significantly fewer side effects than amantadine at equivalent doses, perhaps because of differences in pharmacokinetics, since with equal doses the blood levels are considerably lower. CNS side effects are not significantly higher than placebo.

1-AdaMantanethylaMine Preparation Products And Raw materials

Global( 246)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd.
+8615858145714 fandachem@gmail.com China 9377 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29922 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254 linda@hubeijusheng.com CHINA 28185 58
Hebei Guanlang Biotechnology Co., Ltd.
+86-19930503282 +86-19930503282 alice@crovellbio.com China 6469 58
Chongqing Chemdad Co., Ltd
+undefined-86-13650506873 +undefined-86-13650506873 sales@chemdad.com China 39915 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47427 58
Shaanxi Dideu Medichem Co. Ltd
18192627656 1012@dideu.com China 3945 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
+8613580539051 joe@yuhengpharm.com CHINA 21149 58
SIMAGCHEM CORP
+86-13806087780 +86-13806087780 sale@simagchem.com China 17369 58

Related articles

View Lastest Price from 1-AdaMantanethylaMine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Rimantadine pictures 2022-09-07 Rimantadine
13392-28-4
US $0.00-0.00 / KG 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
Rimantadine pictures 2021-11-15 Rimantadine
13392-28-4
US $200.00 / KG 1KG 99% 500ton/Month Qiuxian Baitai New Material Co., LTD
Rimantadine pictures 2021-11-04 Rimantadine
13392-28-4
US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
  • Rimantadine pictures
  • Rimantadine
    13392-28-4
  • US $0.00-0.00 / KG
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.
  • Rimantadine pictures
  • Rimantadine
    13392-28-4
  • US $200.00 / KG
  • 99%
  • Qiuxian Baitai New Material Co., LTD
  • Rimantadine pictures
  • Rimantadine
    13392-28-4
  • US $10.00 / Kg/Bag
  • 99%
  • Hebei Zhanyao Biotechnology Co. Ltd

1-AdaMantanethylaMine Spectrum

1-Adamantan-1-ylethylamine 1-Adamantanethylamine Rimantadine & Rimantadine Hydrochloride 1-(adaMantan-1-yl)ethanaMine hydrochloride 1-(AdaMantan-1-yl)ethanaMine 1-Adaman 1-ADAMANTANEMETHYLAMINE, alpha-METHYL-, HYDROCHLORIDE Adamantane, 1-(1-aminoethyl)-, hydrochloride Rimantadine hydrochloride [USAN] Tricyclo(3.3.1.13,7)decane-1-methanamine, alpha-methyl-, hydrochloride (9CI) α-Methyl-1-adamantanemethylamine 1-(1-Adamantyl)ethanamine 1-Adamantanemethylamine, alpha-methyl- alpha-Methyl-1-adamantanemethylamine alpha-Methyladamantanemethylamine Tricyclo(3.3.1.13,7)decane-1-methanamine, alpha-methyl- Tricyclo[3,3,1,1(3,7)]decane-1-methanamine, alpha-methyl- 1-(1-ADAMANTYL)ETHYLAMINE AKOS NCG1-0034 AKOS B022266 Levofloxacine Hydrochloride Flunarizine hydrochloride cp2000,BP98 Rimantadine (base and/or unspecified salts) α-Methyl-1-adamantanemethanamine (1R)-1-(1-adamantyl)ethanamine 1-Rimantadine Tricyclo[3.3.1.13,7]decane-1-methanamine, α-methyl- 1-AdaMantanethylaMine USP/EP/BP RiMantadine (FluMadine) RiMantidine RIMANTADINE LEVOFLOXACIN HCL 1-Adamantanemethylamine 13392-28-4 Antibiotics Antibiotics A to Z Antibiotics G-M BioChemical Adamantane derivatives API's Inhibitors