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Rimantadine

Description References
Rimantadine
Rimantadine structure
CAS No.
13392-28-4
Chemical Name:
Rimantadine
Synonyms
1-Adaman;RiMantidine;RIMANTADINE;AKOS B022266;AKOS NCG1-0034;LEVOFLOXACIN HCL;1-Adamantanethylamine;1-Adamantanemethylamine;RiMantadine (FluMadine);1-(1-Adamantyl)ethanamine
CBNumber:
CB7122907
Molecular Formula:
C11H19N
Formula Weight:
165.28
MOL File:
13392-28-4.mol

Rimantadine Properties

Boiling point:
248°C
Density 
1.033
Flash point:
99°C
CAS DataBase Reference
13392-28-4(CAS DataBase Reference)
NIST Chemistry Reference
1-Adamantanemethylamine, «alpha»-methyl-(13392-28-4)

SAFETY

HazardClass  IRRITANT
Hazardous Substances Data 13392-28-4(Hazardous Substances Data)

Rimantadine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy

Rimantadine Chemical Properties,Uses,Production

Description

Rimantadine (Brand name: Flumadine) is a kind of RNA synthesis inhibitor that used as an orally administrated antiviral drug in the prophylaxis and for the treatment of influenza. It is capable of shortening the duration and alleviated the symptoms of influenza. However, it is now not recommended for the treatment of influenza any longer due to the emergence of resistance problem since 2009. Its mechanism of action is not fully understood. It is indicated that it take effects through inhibiting the viral replication through possibly inhibiting the uncoating process of the virus. The virus M2 protein (an ion channel) seems to play an important role in the susceptibility of influenza A virus to the treatment of Rimantadine.

References

https://www.drugbank.ca/drugs/DB00478
https://en.wikipedia.org/wiki/Rimantadine

Uses

Rimantadine act by blocking the M2 ion channel which is required for uptake of protons into the interior of the virus to permit acid-promoted viral uncoating (decapsidation).

brand name

Flumadine (Forest).

General Description

Resistant variants of influenza type A have been recoveredfrom rimantadine-treated patients.Resistance with inhibitory concentrations increased morethan 100-fold have been associated with single nucleotidechanges that lead to amino acid substitutions in the transmembranedomain of M2. rimantadineshare cross-susceptibility and resistance.

Pharmaceutical Applications

An analog of amantadine, supplied as the hydrochloride for oral administration.

Pharmacokinetics

Oral absorption: >90%
Cmax 100 mg oral (every 12 h): 0.4–0.5 mg/L after 2–6 h
Plasma half-life: c. 35 h
Volume of distribution: Very large
Plasma protein binding: c. 40%
Absorption and distribution
Single- and multiple-dose pharmacokinetic studies in elderly patients and young adults are remarkably similar. The steadystate concentration in nasal mucus develops by day 5 at a concentration approximately 1.5-fold higher than plasma.
Metabolism
In contrast to amantadine, rimantadine is extensively metabolized in the liver by hydroxylation and glucuronidation.
Excretion
Less than 20% is excreted unchanged in the urine and most of the breakdown products are excreted by this route. Thus, the plasma half-life is much less affected by renal dysfunction than that of amantadine.

Clinical Use

Prophylaxis and treatment of influenza A H1N1 infections Since prolonged administration is well tolerated by elderly patients, the drug is preferable to amantadine.

Clinical Use

rimantadine is used for the treatment of diseases caused by influenza A strains.

Side effects

Rimantadine has significantly fewer side effects than amantadine at equivalent doses, perhaps because of differences in pharmacokinetics, since with equal doses the blood levels are considerably lower. CNS side effects are not significantly higher than placebo.

Rimantadine Preparation Products And Raw materials

Raw materials

Preparation Products


Rimantadine Suppliers

Global( 174)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21924 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20094 58
SICHUAN ZHONGBANG TECHNICAL DEVELOPING LIMITED COMPANY +86-830-2585019
+86-830-2589033 info@zhongbangst.com China 99 69
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Arden pharmaceutical &chemical Co., Ltd +86-(0)533-3595900 13793319233
+86-(0)533-3595900 info@chems.com.cn China 670 61

View Lastest Price from Rimantadine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-17 Rimantadine
13392-28-4
US $7.00 / kg 1kg 99% 100KG career henan chemical co

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