Domiphen bromide
- CAS No.
- 538-71-6
- Chemical Name:
- Domiphen bromide
- Synonyms
- DOMIPHEN;Domiphenbromide,97%;pddb;oradol;Mr C m;bradosol;bradoral;bradonit;bradasol;fungitex
- CBNumber:
- CB4271226
- Molecular Formula:
- C22H40BrNO
- Molecular Weight:
- 414.46
- MDL Number:
- MFCD00011769
- MOL File:
- 538-71-6.mol
- MSDS File:
- SDS
| Melting point | 117-119 °C (lit.) |
|---|---|
| Density | 1.1411 (rough estimate) |
| refractive index | 1.5570 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble in ethanol, acetone, ethyl acetate, chloroform and water. Slightly soluble in benzene. |
| Sensitive | Hygroscopic |
| Merck | 14,3415 |
| BRN | 3922742 |
| InChIKey | OJIYIVCMRYCWSE-UHFFFAOYSA-M |
| CAS DataBase Reference | 538-71-6(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | R4CY19YS7C |
| ATC code | A01AB06 |
| EPA Substance Registry System | 1-Dodecanaminium, N,N-dimethyl-N-(2-phenoxyethyl)-, bromide (1:1) (538-71-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | BQ2030000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
Domiphen bromide Chemical Properties,Uses,Production
Description
Domiphen is a quaternary ammonium compound and cationic surfactant with antimicrobial activity. It is active against A. viscosus, A. naeslundii, S. mutans, E. coli, and L. monocytogenes bacteria and inhibits C. neoformans yeast growth and spore germination. It also inhibits the human-ether-a-go-go-related gene (hERG) channel (IC50 = 1.5 μM in a whole-cell patch-clamp assay). Formulations containing domiphen have been used as antiseptics, disinfectants, and biocides in industrial, agricultural, veterinary, and clinical applications.
Originator
Bradosol,Ciba,US,1958
Uses
Antiinfective, topical.
Uses
Domiphen bromide is employed as a phase transfer catalyst in synthetic chemistry. It is used as a quaternary ammonium cation with cationic surfactant properties. Further, it is used as an antiseptic and an active pharmaceutical ingredient.
Definition
ChEBI: Domiphen bromide is an aromatic ether.
Manufacturing Process
7 parts of β-phenoxyethyl-dimethylamine are heated for 2 hours on the boiling water-bath with 11 parts of dodecyl bromide. A good yield of β-phenoxy-ethyldimethyl-dodecyl-ammonium bromide is obtained which, after recrystallization from acetone, melts at 112°C. It is a white crystalline powder which dissolves easily in water to give a neutral reaction.
Therapeutic Function
Topical antiinfective
Safety Profile
Poison by intraperitoneal and intravenous routes. hfutauon data reported. When heated to decomposiuon it emits very toxic fumes of NOx, NH3, and Br-. See also BROMIDES.
Domiphen bromide Preparation Products And Raw materials
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