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Tetrabutylammonium bromide

Tetrabutylammonium bromide Structure
Tetrabutylammonium bromide structure
CAS No.
1643-19-2
Chemical Name:
Tetrabutylammonium bromide
Synonyms
TBAB;TBABr;Bu4NBr;TABA;TETRA-N-BUTYLAMMONIUM BROMIDE;Tetrabutylazanium bromide;ALIQUAT(R) 100;Tetrabutylammoniumbromid;1-Butanaminium, N,N,N-tributyl-, bromide;IPC-TBA-BR
CBNumber:
CB3347418
Molecular Formula:
C16H36BrN
Molecular Weight:
322.37
MDL Number:
MFCD00011633
MOL File:
1643-19-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-12 09:14:19
Product description Number Pack Size Price
Tetrabutylammonium bromide suitable for ion pair chromatography, LiChropur?, ≥99.0% 86857 10g $196
Tetrabutylammonium bromide suitable for ion pair chromatography, LiChropur?, ≥99.0% 86857 50g $768
Tetrabutylammonium bromide ReagentPlus , ≥99.0% 193119 25g $53.7
Tetrabutylammonium bromide ACS reagent, ≥98.0% 426288 1 unit $990
Tetrabutylammonium bromide ReagentPlus , ≥99.0% 193119 5kg $1740
More product size
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Tetrabutylammonium bromide Properties

Melting point 102-106 °C(lit.)
Boiling point 102 °C
Density 1.039 g/mL at 25 °C
bulk density 700kg/m3
vapor pressure 0Pa at 25℃
refractive index n20/D 1.422
Flash point 100℃
storage temp. Store below +30°C.
solubility H2O: 0.1 g/mL, clear, colorless
form Crystalline Powder
pka 0[at 20 ℃]
Specific Gravity 1.007
color White to slightly cream
Odor Amine like
PH 3.5 to 7.0 (50 g/L, 25 ℃)
Water Solubility 600 g/L (20 ºC)
Sensitive Hygroscopic
λmax λ: 240 nm Amax: 0.04
λ: 250 nm Amax: 0.03
λ: 260 nm Amax: 0.02
λ: 500 nm Amax: 0.02
BRN 3570983
Stability Stable. Incompatible with strong oxidizing agents. Protect from moisture.
Cosmetics Ingredients Functions ANTIMICROBIAL
ANTISTATIC
InChI 1S/C16H36N.BrH/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;/h5-16H2,1-4H3;1H/q+1;/p-1
InChIKey JRMUNVKIHCOMHV-UHFFFAOYSA-M
SMILES [Br-].CCCC[N+](CCCC)(CCCC)CCCC
LogP 0.839 at 25℃
CAS DataBase Reference 1643-19-2(CAS DataBase Reference)
FDA UNII VJZ168I98R
NIST Chemistry Reference Tetra-N-butylammonium bromide(1643-19-2)
EPA Substance Registry System Tetrabutylammonium bromide (1643-19-2)
UNSPSC Code 12352111
NACRES NB.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H412
Precautionary statements  P264-P270-P273-P301+P312-P302+P352-P305+P351+P338
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  26-36-37/39
WGK Germany  3
F  3
Hazard Note  Irritant
TSCA  TSCA listed
HS Code  29239000
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Aquatic Chronic 3
Eye Irrit. 2
Repr. 2
Skin Irrit. 2
REACH Registrations Active
NFPA 704
0
2 1

Tetrabutylammonium bromide price More Price(78)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 86857 Tetrabutylammonium bromide suitable for ion pair chromatography, LiChropur?, ≥99.0% 1643-19-2 10g $196 2026-04-30 Buy
Sigma-Aldrich 86857 Tetrabutylammonium bromide suitable for ion pair chromatography, LiChropur?, ≥99.0% 1643-19-2 50g $768 2026-04-30 Buy
Sigma-Aldrich 193119 Tetrabutylammonium bromide ReagentPlus , ≥99.0% 1643-19-2 25g $53.7 2026-04-30 Buy
Sigma-Aldrich 426288 Tetrabutylammonium bromide ACS reagent, ≥98.0% 1643-19-2 1 unit $990 2026-04-30 Buy
Sigma-Aldrich 193119 Tetrabutylammonium bromide ReagentPlus , ≥99.0% 1643-19-2 5kg $1740 2026-04-30 Buy
Product number Packaging Price Buy
86857 10g $196 Buy
86857 50g $768 Buy
193119 25g $53.7 Buy
426288 1 unit $990 Buy
193119 5kg $1740 Buy

Tetrabutylammonium bromide Chemical Properties,Uses,Production

Physical and Chemical Properties

Tetrabutylammonium bromide, also known as tetrabutylammonium bromide. White crystal, deliquescence. 118 ℃ melting point. Soluble in water, alcohol, ether and acetone, slightly soluble in benzene.

Figure 1:  a structural formula of tetrabutylammonium bromide

Application

(1) Used as a reagent for the analysis of organic synthesis.
(2) Tetrabutylammonium bromide is also an effective phase transfer catalyst.
Phase transfer catalyst, referred to as PTC, is able to transfer the aqueous phase (or organic phase) to the organic phase (or aqueous phase) catalyst, which can make the reaction between the aqueous phase and the organic phase of the catalyst. PTC has the function of changing the degree of ion solvation, increasing the activity of ion reaction, speeding up the reaction rate and so on. Solve the problem of the past in the two phases of the reaction is difficult to react.
Common quaternary ammonium salt phase transfer catalysts are: benzyl triethyl ammonium chloride, trioctyl methyl ammonium chloride, tetramethyl ammonium bromide, tetrapropylammonium chloride, tetrabutylammonium bromide , tetrabutyl ammonium iodide, benzyl triethyl ammonium bromide, triethyl hexyl bromide, octyl triethylammonium bromide.
Phase transfer catalyst is widely applied in organic synthesis: R2C for preparing compounds (carbene type compound), further preparation of the corresponding nitrile, isonitrile, Halon, dichloromethane cyclopropane derivatives, hydroxy acids and diazomethane. For the alkylation reaction, compared with traditional methods, to avoid the harsh conditions of dry operation, and high yield, it can also be used in the redox reaction, ester hydrolysis, substitution reaction, condensation reaction, addition reaction, polymerization reaction, addition reaction of carbon and the elimination of reaction and so on.
(3) For organic synthesis intermediates, phase transfer catalyst
(4) Ion-pairing reagents for the synthesis of bacampicillin, sultamicillin like.
(5) Ion pair chromatography reagents, phase transfer catalyst. Bacampicillin, sultamicillin like synthesis.

Uses

Tetrabutylammonium bromide (TBAB) is a quaternary ammonium compound. It is the most widely used phase transfer catalyst. Its interfacial properties have been studied in case of hydroxide initiated reactions. This may be applied in understanding the mechanism of phase transfer reactions. TBAB is reported to decrease retention time and remove peak tailing by acting as an ion pair reagent during the chromatographic analysis of quaternary ammonium compounds. In the molten state TBAB behaves like an ionic liquid which is a promising green alternative to organic solvents in organic synthesis. Its molar heat capacity, entropy and free energy function have been determined.
Recently, molten tetrabutylammonium bromide (TBAB) was used as a low toxic and cost-effective IL in a number of constructive synthetic transformations.
Tetrabutylammonium bromide (TBAB) may be used in the molten state in the following processes:
Synthesis of (2S)-5-(3-phenyl-2-phthalimidylpropanoylamino)isophthalic acid.
Synthesis of alkyl-substituted pyrroles in the absence of catalyst and organic solvent.
Synthesis of dithioacetals from acetals by transthioacetalisation in a solvent free environment.
Synthesis of polyamides (PAs) by the polymerization of terephthalic acid and diisocyanates.
Catalyze the addition of thiols to conjugated alkenes.
Dehydrochlorination of poly(vinyl chloride).

preparation

Preparative Methods: several methods are available to recover the quaternary ammonium ion efficiently.Prepared by reaction of tri-n-butylamine and n-butyl bromide.

Toxicity

The acute oral LD50 (mouse): 590mg/kg. Inhalation, ingestion and skin contact toxic to the skin, eyes and respiratory system irritation.
More information from the ChemicalBook Xiaonan editor (2015-09-16).

Chemical Properties

white crystals or powder

Uses

Tetrabutylammonium Bromide is used in the synthesis of polymer solar cells. Also used in the synthesis of single component green-light emitting electrochemical cells.

Definition

ChEBI: Tetrabutylammonium bromide is a tetrabutylammonium salt with bromide as the anionic counterpart. It is an organic bromide salt and a tetrabutylammonium salt.

benefits

Tetrabutylammonium bromide is an environmentally benign, non-volatile, non-flammable, non-corrosive, low-cost, commercially available ammonium salt with high thermal and chemical stability. In TBAB, tetrabutylammonium salt can dissolve in both aqueous as well as in organic solvents, which helps to transport the water-soluble anionic reactants into the organic phase. Moreover, molten TBAB was also employed as an efficient ionic liquid to carry out organic transformations under solvent-free conditions[1].

General Description

Tetrabutylammonium bromide, a quaternary ammonium compound widely used as a phase transfer catalyst. TBAB decreases the retention time and removes peak tailing by acting as an ion pair reagent during the chromatographic analysis of quaternary ammonium compounds. In the molten state, TBAB behaves like an ionic liquid, which is a promising green alternative to organic solvents in polymer synthesis.

Flammability and Explosibility

Not classified

Purification Methods

Crystallise the salt from *benzene (5mL/g) at 80o by adding hot n-hexane (three volumes) and allowing to cool. Dry it over P2O5 or Mg(ClO4)2, under vacuum. The salt is very hygroscopic. It can also be crystallised from ethyl acetate or dry acetone by adding diethyl ether and dried in vacuo at 60o for 2 days. It has been crystallised from acetone by addition of diethyl ether. It is so hygroscopic that all manipulations should be carried out in a dry-box. It has been purified by precipitation from a saturated solution in dry CCl4 on addition of cyclohexane or by recrystallisation from ethyl acetate, then heating in vacuum to 75o in the presence of P2O5. [Symons et al. J Chem Soc, Faraday Trans 1 76 2251 1908.] It also recrystallises from CH2Cl2/diethyl ether and is dried in a vacuum desiccator over P2O5. [Blau & Espenson J Am Chem Soc 108 1962 1986, Beilstein 4 IV 657.]

Toxics Screening Level

The ITSL for t-n-butyl ammonium bromide has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on an annual averaging time.

References

[1] Banik B, et al. Tetrabutylammonium Bromide (TBAB) Catalyzed Synthesis of Bioactive Heterocycles. Molecules, 2020; 25: 5918.

Tetrabutylammonium bromide synthesis

109-65-9
102-82-9
1643-19-2
Synthesis of Tetrabutylammonium bromide from 1-Bromobutane and Tributylamine

Tetrabutylammonium bromide Preparation Products And Raw materials

Raw materials

Preparation Products

Venlafaxine hydrochloride 3-AMINOBIPHENYL Albendazole 4-(tert-Butyl)benzyl mercaptan CYCLANILIDE
5-Bromobenzo[c]thiophene 3-PHENYLBENZYLAMINE cintofen 1-Phenylcyclopentanecarboxylic acid 2-[2-(DIPHENYLPHOSPHINO)ETHYL]PYRIDINE
2-(4-ETHOXYPHENYL)-2-METHYL PROPIONITRILE 1-BENZOTHIOPHENE-5-CARBONITRILE 5-bromo-1H-indazole Isocarbophos 1-BENZOTHIOPHENE-5-CARBOXYLIC ACID
Olaquindox Piperonyl aldehyde H-GLY-AMC HBR Levetiracetam 4-Bromo-7-azaindole
Tetrabutylammonium borohydride alpha-butyl-alpha-phenyl-1H-imidazole-1-propiononitrile Phenyl vinyl sulfone Myclobutanil ETHYL 4-ETHOXYPHENYLACETATE
1,1-Cyclopropanedicarboxylic acid dimethyl ester N-(4-THIOPHEN-2-YL-PHENYL)-ACETAMIDE 4-PYRIDIN-2-YLISOXAZOL-5-AMINE FENOTHIOCARB (R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol
Zeolite 1-(3-Aminopropyl)piperidine Glyceryl monostearate 6-Bromopurine Tetrabutylammonium hexafluorophosphate
DIOCTYL ETHER Thianaphthene-2-carboxylic acid 2 -phenyl-Hexanenitrile Sisthsne Methyl 3,4,5-trimethoxybenzoate

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Related Qustion

Ask a question
Q:Can tetrabutylammonium bromide(TBAB) be used as a phase-transfer catalyst or an ionic liquids?Zora - Apr 14，2026
A: Yes! Tetrabutylammonium bromide(TBAB) is an environmentally benign, non-volatile, non-flammable, non-corrosive, low-cost, commercially available ammonium salt with high thermal and chemical stability. TBAB has gained significant attention as an efficient metal-free homogeneous phase-transfer catalyst. A catalytic amount of TBAB is sufficient to catalyze various alkylation, oxidation, reduction, and esterification processes. It is also employed as an efficient co-catalyst for numerous coupling reactions. Moreover, molten TBAB was also employed as an efficient ionic liquid to carry out organic transformations under solvent-free conditions.

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Tetrabutylammonium bromide pictures 2026-05-14 Tetrabutylammonium bromide
1643-19-2
 US $37.00 / kg 1kg 0.99 100kg Shanghai UCHEM Inc.
Tetrabutylammonium bromide pictures 2026-05-14 Tetrabutylammonium bromide
1643-19-2
 US $0.00 / KG 1KG ≥99% 60 Tons/Month Yancheng Longshen Chemical Co.,Ltd.
Tetrabutylammonium bromide pictures 2026-05-14 Tetrabutylammonium bromide
1643-19-2
 US $1.00 / g 1g 99% 100kg RongNa Biotechnology Co.,Ltd

Tetrabutylammonium bromide Spectrum

Tetrabutylammonium bromide(1643-19-2)MSTetrabutylammonium bromide(1643-19-2)1HNMRTetrabutylammonium bromide(1643-19-2)13CNMRTetrabutylammonium bromide(1643-19-2)IR1Tetrabutylammonium bromide(1643-19-2)IR2Tetrabutylammonium bromide(1643-19-2)Raman

1643-19-2(Tetrabutylammonium bromide)Related Search:

Rocuronium bromide Molybdic acid Tetrapropylammonium bromide Ethidium bromide Tetraheptylammonium bromide
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Ammonium formate Ammonium acetate TETRABUTYLAMMONIUM BROMIDE PERBROMIDE (TRIBROMIDE),TBABr3, Tetrabutylammonium bromide perbromide,TETRABUTYLAMMONIUM BROMIDE PERBROMIDE Ammonium chloride Sodium bromate
Ammonium bromide Tetrabutylammonium acetate Ammonium hydroxide

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n,n,n-tributyl-1-butanaminiubromide Tetrabutylaminium·bromide 1-Butanaminium,N,N,N-tributyl-, bromide (1:1) Tetrabutylammonium b TetrabutylaMMoniuM BroMide(Ipc-Tba-Br ) TetrabutylaMMoniuM broMide, 99+% 100GR TetrabutylaMMoniuM broMide, 99+% 25GR TetrabutylaMMoniuM broMide, 99+% 500GR FourbutylbroMide Butyl AMoniuM BroMide TetrabutylaMMoniuM broMide, for ion pair chroMatography TETRA BUTYL AMMONIUM BROMIDE & 50% H2O SOLUTION Tetrabutyllammonium bromide Tetrabutylammonium bromide ACS reagent, >=98.0% Tetrabutylammonium bromide ReagentPlus(R), >=99.0% Tetrabutylammonium bromide Vetec(TM) reagent grade, 99% N4,4,4,4Br Tetra butyl ammonium bromide Solid & in 50% H2O Solution Tetra-n-butylammonium bromide for synthesis TETRABUTYLAMMONIUM BROMIDE SOLUTION TETRABUTYLAMMONIUM BROMIDE TETRABUTYL AMONIUM BROMIDE 4-BUTYLBENZALDEHYDE DIETHYL ACETAL, TECH ., 90% TETRABUTYLAMMONIUM BROMIDE SOLUTION, ~50% IN WATER TETRABUTYLAMMONIUM BROMIDE, ELECTRO-CHEM ICAL GRADE TETRABUTYLAMMONIUM BROMIDE, 98+%, A.C.S. REAGENT TETRABUTYLAMMONIUM BROMIDE, FOR IPC Tetrabutylammonium bromide 50 % TETRABUTYLAMMONIUM BROMIDE REAGENTPLUS& TETRABUTYLAMMONIUM BROMIDE CONC., FOR TETRABUTYLAMMONIUM BROMIDE, 50 WT. % SOL UTION IN WATER TetraButylAmmoniumBromideTbab TetraButylAmmoniumBromideForSynthesis TetraButylAmmoniumBromideGr Tetrabutylammonium bromide≥ 99.5% (Assay) Tetra butyl ammonium bromide in 50% H2O Solution Tetrbutyl Ammonium Bromide Tetrabutylammonium bromide, 99+% TETRABUTYLAMMONIUM BROMIDE REAGENT (ACS) aliquat 100 TETRA BUTYL AMMONIUM BROMIDE AQUEOUS SOLUTION (TBA TETRA BUTYL AMMONIUM BROMIDE SOLID (TBAB) TETRA BUTYL AMMONIUM BROMIDE SOLID (TBAB) 50% SOLU Tetra-n-butylammonium bromide, 98+% Tetrabutylammonium Bromide [Reagent for Ion-Pair Chromatography] TETRABUTYLAMMONIUM BROMIDE extrapure AR Tetrabutylammonium bromide, 99%, for ion-pair chromatography TETRA BUTYL AMMONIUM BROMIDE & 50% H2O SOLUTION TBAB TBAB/Tetrabutylammonium bromide TETRABUTYLAMMONIUM BROMIDE, REAGENT (ACS)TETRABUTYLAMMONIUM BROMIDE, REAGENT (ACS)TETRABUTYLAMMONIUM BROMIDE, REAGENT (ACS)TETRABUTYLAMMONIUM BROMIDE, REAGENT (ACS) Tetrabutylammonium Bromide [Reagent for Ion-Pair Chromatography] > Tetrabutylammonium Bromide > Sildenafil Impurity 77 etrabutylammoniumbromide Tetrabutylammonium bromid / TBAB Tetra Butyl Ammonium Bromide (TBAB)& 50% Solution TBAB solution Tetrabutylammonium bromide(Reagent for Ion-Pair Chromatography,99%)