8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one
![8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one Structure](CAS/20180702/GIF/599151-35-6.gif)
- CAS No.
- 599151-35-6
- Chemical Name:
- 8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one
- Synonyms
- FQI1;FQI1 (FQI 1);FQI1 >=98% (HPLC);8-(2-ethoxyphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one;8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one;1,3-Dioxolo[4,5-g]quinolin-6(5H)-one, 8-(2-ethoxyphenyl)-7,8-dihydro-
- CBNumber:
- CB42750581
- Molecular Formula:
- C18H17NO4
- Molecular Weight:
- 311.33
- MDL Number:
- MFCD03632583
- MOL File:
- 599151-35-6.mol
- MSDS File:
- SDS
| Boiling point | 463.6±45.0 °C(Predicted) |
|---|---|
| Density | 1.272±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL (clear solution) |
| form | powder |
| pka | 13.36±0.40(Predicted) |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H400 | |||||||||
| Precautionary statements | P273-P301+P310 | |||||||||
| Hazard Codes | T,N | |||||||||
| Risk Statements | 25-50 | |||||||||
| Safety Statements | 45-61 | |||||||||
| RIDADR | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0413 | FQI1 ≥98% (HPLC) | 599151-35-6 | 5mg | $127 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0413 | FQI1 ≥98% (HPLC) | 599151-35-6 | 25mg | $505 | 2024-03-01 | Buy |
| Cayman Chemical | 23104 | FQI 1 | 599151-35-6 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 23104 | FQI 1 | 599151-35-6 | 10mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 23104 | FQI 1 | 599151-35-6 | 25mg | $429 | 2024-03-01 | Buy |
8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one Chemical Properties,Uses,Production
Description
FQI1 (599151-35-6) is an inhibitor of transcription factor LSF specifically targeting its DNA binding and corresponding transcriptional activity (IC50=2.1 μM). Rapidly induces apoptosis in an aggressive hepatocellular carcinoma (HCC) cell line and dramatically inhibits tumor growth in a mouse xenograft model with no general tissue cytotoxicity.1,2?In human HCC cells, FQI1 induced mitotic arrest with an accompanying increase in cyclin B1.3?Blocks LSF-stimulated activation of DNA methyltransferase 1.4?Cell permeable.
References
1) Grant?et al.?(2012),?Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma; Proc. Natl. Acad. Sci. USA,?109?4503 2) Santhekadur?et al. (2012),?The transcription factor LSF: a novel oncogene for hepatocellular carcinoma; Am. J. Cancer Res.,?2?269 3) Raiasekaran?et al. (2015),?Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model;?Oncotarget?6?26266 4) Chin?et al.?(2016),?Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression; Oncotarget,?7?83627
8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2494 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 5141 | 58 |