ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID
- CAS No.
- 31842-01-0
- Chemical Name:
- ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID
- Synonyms
- k4277;flosin;Praxis;flosint;Bor-ind;Reumofe;isindone;Reumofene;INDOPROFEN;Aids025462
- CBNumber:
- CB4297426
- Molecular Formula:
- C17H15NO3
- Molecular Weight:
- 281.31
- MDL Number:
- MFCD00057144
- MOL File:
- 31842-01-0.mol
- MSDS File:
- SDS
Melting point | 213-214° |
---|---|
Boiling point | 423.97°C (rough estimate) |
Density | 1.1302 (rough estimate) |
refractive index | 1.4500 (estimate) |
storage temp. | 2-8°C |
solubility | Methanol (Slightly, Sonicated) |
form | Solid |
pka | pKa 5.8 (Uncertain) |
color | White to off-white |
FDA UNII | CPE46ZU14N |
ATC code | M01AE10 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06,GHS08 |
---|---|
Signal word | Danger |
Hazard statements | H301-H351 |
Precautionary statements | P201-P301+P310+P330 |
Hazard Codes | T |
Risk Statements | 25-40 |
Safety Statements | 22-36/37/39-45 |
RIDADR | UN 2811 6.1 / PGIII |
WGK Germany | 3 |
RTECS | MU6645000 |
Toxicity | LD50 in rats (mg/kg): 58.66 i.v.; 60.83 orally (Buttinoni) |
ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID price More Price(14)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | I3132 | Indoprofen analytical standard | 31842-01-0 | 1g | $40.5 | 2022-05-15 | Buy |
TRC | I645000 | Indoprofen | 31842-01-0 | 10mg | $110 | 2021-12-16 | Buy |
TRC | I645000 | Indoprofen | 31842-01-0 | 250mg | $715 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0008560 | INDOPROFEN 95.00% | 31842-01-0 | 1G | $525 | 2021-12-16 | Buy |
AK Scientific | X6838 | Indoprofen | 31842-01-0 | 100mg | $495 | 2021-12-16 | Buy |
ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID Chemical Properties,Uses,Production
Chemical Properties
ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID is Off-White Solid
Originator
Flosint,Carlo Erba,Italy,1976
Uses
analgesic, antiinflammatory
Uses
ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID is a non-steroidal anti-inflammatory agent used for treatment of pain and inflammation
Definition
ChEBI: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causi g severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.
Manufacturing Process
The mixture of 7.9 g of ethyl α-(4-aminophenyl)propionate and 8.3 g of ethyl 2-chloromethylbenzoate is refluxed under nitrogen for one hour. The residue is recrystallized from hexane, to yield the ethyl α-[4-(1-oxo-isoindolino)-phenyl]- propionate of the formulamelting at 104° to 106°C. The mixture of 4.5 g thereof, 1.6 g of potassiumhydroxide, 2 ml of water and 250 ml of ethanol is refluxed under nitrogen for 2 hours and evaporated under reduced pressure. The residue is taken up in water, the solution washed with chloroform, acidified with hydrochloric acid and extracted with ethyl acetate. The extract is dried, evaporated and the residue recrystallized from ethyl acetate, to yield the corresponding free acid melting at 208° to 210°C. (Procedure reported in US Patent 3,767,805.)
brand name
Endyne;Fenint;Flogosan;Flosine;Flosyn;K 4277;Miantor.
Therapeutic Function
Antiinflammatory
World Health Organization (WHO)
Indoprofen, a nonsteroidal anti-inflammatory agent, was introduced in 1976 for the treatment of rheumatic disorders. By 1983 its use had been associated with serious adverse effects, some of which were fatal. This led to its withdrawal in the United Kingdom and Cyprus. In 1984 reports of intestinal tumours in rats led to the drug's temporary withdrawal in Germany and Italy. This was followed immediately by the suspension of marketing worldwide by the major manufacturer.
ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID Preparation Products And Raw materials
Raw materials
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Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9294 | 55 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29822 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40068 | 58 |
DONBOO AMINO ACID COMPANY | +8613063595538 | donboo@donboo.com | China | 9365 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Lastest Price from ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2020-03-06 | ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID
31842-01-0
|
US $1.00 / KG | 1KG | 99% | 200kg | Career Henan Chemical Co |
- ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID
31842-01-0
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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