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Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:


Melting point:
Boiling point:
161-162 °C(lit.)
1.68 g/mL at 25 °C(lit.)
vapor pressure 
4.5 at 25 °C (Mackay and Shiu, 1981)
refractive index 
n20/D 1.502(lit.)
Flash point:
storage temp. 
Miscible with alcohol and ether (Windholz et al., 1983)
chloroform-like odor
Water Solubility 
Insoluble in water.
Henry's Law Constant
2.11 at 30 °C (headspace-GC, Sanz et al., 1997)
Stable. Non-flammable. Incompatible with strong oxidizing agents. May react violently with alkalies or metals.
CAS DataBase Reference
76-01-7(CAS DataBase Reference)
EWG's Food Scores
3 (Vol. 41, Sup 7, 71) 1999
EPA Substance Registry System
Pentachloroethane (76-01-7)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H315-H319-H331-H225-H301+H311+H331-H370-H373-H302-H351-H372-H411
Precautionary statements  P210-P260-P280-P301+P310+P330-P308+P311-P403+P233-P273-P301+P312+P330-P314-P391-P501-P201-P202-P261-P264-P270-P271-P302+P352+P332+P313+P362+P364-P304+P340+P311-P305+P351+P338+P337+P313-P308+P313-P405-P501a
Hazard Codes  T,N
Risk Statements  40-48/23-51/53-48/20-39/23/24/25-36/38-23/24/25-11
Safety Statements  23-36/37-45-61-26
RIDADR  UN 1669 6.1/PG 2
WGK Germany  2
RTECS  KI6300000
HazardClass  6.1
PackingGroup  II
Toxicity MLD (mg/kg) in dogs: 1750 orally; 100 i.v.; in rabbits: 700 s.c. (Barsoum, Saad)


Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P2000 Pentachloroethane 95% 76-01-7 5ml-a $38.4 2020-08-18 Buy
Sigma-Aldrich P2000 Pentachloroethane 95% 76-01-7 5 mL $40.1 2021-03-22 Buy
Sigma-Aldrich 40300-U Pentachloroethane solution certified reference material, 5000 μg/mL in methanol 76-01-7 u $44.6 2018-11-13 Buy

PENTACHLOROETHANE Chemical Properties,Uses,Production

Chemical Properties

colourless liquid with a camphor-like smell.Pentachloroethane is incompatible and very reactive in contact with sodium potassium (alloy + bromoform), alkalis, metals, and water. On hydrolysis, pentachloroethane produces dichloroacetic acid and the reaction with alkalis and metals produces chloroacetylenes, which becomes spontaneously explosive. Pentachloroethane is a colourless stable liquid with a camphor-like smell and non-flammable. Pentachloroethane is incompatible with strong oxidising agents and reacts violently with alkalis or metals.

Physical properties

Clear, colorless liquid with a sweetish, chloroform-like odor


Solvent for chemicals, resins, gums; removing oil and grease from metal parts; dry cleaning agent; timber drying agent; fumigant.


Pentachloroethane has been used as a solvent and chemical intermediate but has had little commercial utilization. Pentachloroethane is used as a solvent for oil and grease in metal cleaning; in the separation of cola from impurities by density difference; as a chemical intermediate in the manufacture of tetrachloroethylene and dichloroacetic acid; as a solvent for cellulose acetate, certain cellulose ethers, resins, and gums; as a drying agent for timber by immersion at temperatures greater than 100C; in dry cleaning and soil sterilizing.


May occur as an intermediate in the production of chlorinated ethylenes; formerly used as a solvent for cellulose ethers, resins, and gums, for dry cleaning, coal purification, as a soil sterilizing agent, and as a chemical intermediate in the production of dichloroacetic acid

General Description

A colorless liquid with a chloroform-like odor. Insoluble in water and denser than water. Toxic by inhalation and ingestion. May irritate skin and eyes. Used as a solvent.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A mixture of PENTACHLOROETHANE with potassium may explode after a short delay. Reaction with alkalis or metals will produce a violent reaction. PENTACHLOROETHANE also reacts violently with NaK alloy + bromoform. PENTACHLOROETHANE is incompatible with strong oxidizing agents.

Health Hazard

Irritation of skin, lungs, eyes, and mucous membrane; depression of central nervous system; and toxicity similar to tetrachloroethanes.

Safety Profile

Poison by inhalation and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. An irritant. Questionable carcinogen with experimental carcinogenic data. Flammable when exposed to heat or flame. Moderately explosive by spontaneous chemical reaction. To fight fire, use water, CO2, dry chemical. Dehalogenation by reaction with alkalies, metals, etc., wdl produce spontaneously explosive chloroacetylenes. Violent reaction with NaK alloy + bromoform. Mixtures with potassium are very shock-sensitive explosives. When heated to decomposition it emits highly toxic fumes of Cl-. See also CHLORINATED HYDROCARBONS, ALIPHATIC.


The NTP performed a carcinogenesis/ general toxicity bioassay with F344/N rats and B6C3F1 mice. Chronic inflammation of the kidney and interstitial inflammation of lung were observed in male rats with a positive dose–response relationship. A Frank effect level of 54 for male rats was observed. NTP concluded that “Under the conditions of this bioassay, technical grade pentachlorethane containing 4.2% hexachlorethane (known carcinogen in mice) was not carcinogenic in F344/N rats. The decreased survival of dosed rats was confounding. Pentachloroethane was nephrotoxic to male rats. Technical grade pentachloroethane was carcinogenic for B6CeF1 mice, causing hepatocellular carcinomas in males and females and adenomas in females. This study was cited by IARC as a limited evidence for the carcinogenicity of pentachloroethane in experimental animals. Combined with the lack of epidemiological data for exposure, IARC stated that pentachloroethane was not classifiable as carcinogenic to humans. There is concern for the possibility of a-2 m-globulin nephropathy occurring. However, considering that the pathological sequence of lesions has not been fully established, this cannot be verified. When fed 5 days/week to male rats for 104 weeks at doses of 75 and 150 mg/kg/day, mortality was excessive and body weight gain was below controls starting at 76 weeks. Weight gain was decreased in female rats at both levels starting at 42 weeks, but mortality in both sexes was increased only at 150 mg/kg/day.No increase in tumors was found, but there was a dose-related increase in the incidence of chronic renal inflammation of male rats and mineralization of renal papillae.
Survival of mice similarly treated with 250–500 mg/kg/ day was significantly shortened, and hepatocellular carcinomas were increased. The only other tumor showing an increase was in female mice, where there was a dose-related increase in hepatocellular adenoma. The cause of death did not appear to be either the renal lesions in male rats or the liver tumors in mice, and no other target organs were found to explain the deaths.

Environmental Fate

Chemical/Physical. At various pHs, pentachloroethane hydrolyzed to tetrachloroethylene (Jeffers et al., 1989; Roberts and Gschwend, 1991). Dichloroacetic acid was also reported as a hydrolysis product. Reacts with alkalies and metals producing explosive chloroacetylenes (NIOSH, 1997). The reported hydrolysis half-life at 25 °C and pH 7 is 3.6 d (Jeffers et al., 1989).
In anoxic hypolimnion samples collected from Lower Mystic Lake, MA, pentachloroethane was abiotically transformed within days to tetrachloroethylene via dehydrohalogenation pathway and to trichloroethylene via reductive elimination. After 10 d, mass balances of 91 and 86% were reported for unaltered and filter-sterilized samples, respectively. A disappearance rate constant of 0.26/d was reported for pentachloroethane for both the unaltered and filter-sterilized samples. The disappearance of pentachloroethane was abiotic in origin due to the reactions with naturally occurring aqueous polysulfides, H2S and Sn-2 (Miller et al., 1998a).
The evaporation half-life of pentachloroethane (1 mg/L) from water at 25 °C using a shallowpitch propeller stirrer at 200 rpm at an average depth of 6.5 cm was 46.5 min (Dilling, 1977).

Purification Methods

Usual impurities include trichloroethylene. It partially decomposes if it is distilled at atmospheric pressure. Drying it with CaO, KOH or sodium is unsatisfactory because of the elimination of the elements of HCl. It can be purified by steam distillation, or by washing with conc H2SO4, water, and then aqueous K2CO3, drying with solid K2CO3 or CaSO4, and fractionally distilling under reduced pressure. [Beilstein 2 IV 147.]

PENTACHLOROETHANE Preparation Products And Raw materials

Raw materials

Preparation Products


Global( 59)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23035 58
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 CHINA 9937 58
Yangzhou Model Electronic Materials Co., Ltd.
+8613761402923 CHINA 440 58
Mainchem Co., Ltd. +86-0592-6210733
+86-0592-6210733 CHINA 32439 55
Yangzhou modier Electronic Materials Co., Ltd 13761402923 China 310 58
J & K SCIENTIFIC LTD. 400-666-7788 010-82848833-
86-10-82849933; China 96815 76
Alfa Aesar 400-610-6006
021-67582001/03/05 China 30159 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 China 24555 81
Energy Chemical 400-005-6266 021-58432009-
021-58436166 China 43495 61
shanghai science,ltd. 13482412995 0215-7872719-
02157872719 China 298 60

View Lastest Price from PENTACHLOROETHANE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-01-14 Pentachloroethane
US $0.10 / KG 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd


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