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5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE

5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE structure

CAS No.: 979-92-0

Chemical Name:: 5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE

Synonyms: S-ADENOSYL-L-HOMOCYSTEINE;s-adenosylhomocysteine;ADOHCY;hpce;Adenosylhomocysteine;S-Adenosyl-L-homocystein;S-(5'-ADENOSYL)-L-HOMOCYSTEINE;5'-DEOXY-S-ADENOSYL-;Adenosyl-L-homocysteine;L-S-AdenosylhoMocysteine

CBNumber:: CB4451354

Molecular Formula:: C14H20N6O5S

Molecular Weight:: 384.41

MDL Number:: MFCD00037388

MOL File:: 979-92-0.mol

Last updated:2023-05-18 11:31:00

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5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE Properties

Melting point	209-211 °C
Boiling point	787.5±70.0 °C(Predicted)
Density	1.91±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	1 M HCl: soluble19.60 - 20.40mg/mL, clear to slightly hazy, colorless to faintly yellow
form	crystalline
pka	2.22±0.10(Predicted)
color	Off-White to Brown
BRN	99188
Stability	Hygroscopic
InChIKey	ZJUKTBDSGOFHSH-WFMPWKQPSA-N
FDA UNII	8K31Q2S66S

SAFETY

Risk and Safety Statements

WGK Germany	3
F	8-10-23
HS Code	2934990002

5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A9384	S-(5′-Adenosyl)-L-homocysteine crystalline	979-92-0	10mg	$106	2024-03-01	Buy
Sigma-Aldrich	1012112	S-(5′-Adenosyl)-L-homocysteine United States Pharmacopeia (USP) Reference Standard	979-92-0	50mg	$436	2024-03-01	Buy
Cayman Chemical	13603	S-Adenosylhomocysteine ≥98%	979-92-0	5mg	$37	2024-03-01	Buy
Cayman Chemical	13603	S-Adenosylhomocysteine ≥98%	979-92-0	10mg	$62	2024-03-01	Buy
Sigma-Aldrich	A9384	S-(5′-Adenosyl)-L-homocysteine crystalline	979-92-0	25mg	$179	2024-03-01	Buy

Product number	Packaging	Price	Buy
A9384	10mg	$106	Buy
1012112	50mg	$436	Buy
13603	5mg	$37	Buy
13603	10mg	$62	Buy
A9384	25mg	$179	Buy

5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE Chemical Properties,Uses,Production

Description

S-Adenosyl-L-homocysteine (SAH) is an amino acid derivative and an intermediate, by-product, or modulator of several metabolic pathways, including the activated methyl cycle and cysteine biosynthesis. It is also a product of S-adenosyl-methionine (SAM)-dependent methylation of biological molecules, including DNA, RNA, and histones and other proteins. SAH is a risk factor for many diseases, including cancer and neurodegenerative diseases. In addition, inhibitors that block its hydrolysis are being developed as anti-viral, anti-parasitic, anti-arthritic and immunosuppressive agents.

Chemical Properties

Pale Beige Solid

Uses

A novel biomarker for predicting susceptibility of a subject to a mental or neurodegenerative disorder.

Uses

SAH is suitable for use:

to investigate whether AdoHcy competes with AdoMet in the down-regulation of reporter activity of LUC reporter gene
as a reagent to study the abundance patterns of SAH and its correlation with vertebrate metamorphosis
in the optimization of the protein (lysine K) methyltransferase SET7/9 activity assay
in the fluorescence polarization (FP) assay during dengue virus methyltransferase activity measurement
as a standard for the measurement of SAH from blood samples by high performance liquid chromatography (HPLC) with fluorimetric detection method

Definition

ChEBI: The S-adenosyl derivative of L-homocysteine.

Biochem/physiol Actions

S-(5′-Adenosyl)-L-homocysteine (AdoHcy/SAH) is a component of intracellular homocysteine stress. AdoHcy is a competitive inhibitor (versus AdoMet) of DNA methyltransferases (S-adenosyl-L-methionine (AdoMet)-dependent methyltransferases) involved in epigenetics. Consequently, AdoHcy is used in a variety of studies on epigenetics in hyperhomocysteinemic states. AdoHcy is metabolized by S-adenosylhomocysteine hydrolase (AHCY). AdoHcy is the product of enzymatic transmethylation reactions involving S-Adenosylmethionine (SAM). It is reconverted to SAM by its cleavage into adenosine and L-homocysteine, a substrate of thetin-homocysteine S-methyltransferase. The concentration alterations of SAM and SAH in plasma serve as predictors of cellular methylation potential and metabolic alterations. Methylation capacity indicates specific genetic polymorphisms and/or nutritional deficiencies. Methylation is important in epigenetics, reprogramming, and cancer.

Purification Methods

It has been recrystallised several times from aqueous EtOH or H2O to give small prisms and has max 260nm in H2O. The picrate has m 170o(dec) from H2O. [Baddiley & Jameison J Chem Soc 1085 1955, de la Haba & Cantoni J Biol Chem 234 603 1959, Borchardt et al. J Org Chem 41 565 1976, NMR: Follmann et al. Eur J Biochem 47 187 1974, Beilstein 26 III/IV 3676.]

5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE synthesis

Synthesis of 5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE from 5'-CHLORO-5'-DEOXYADENOSINE

5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE Preparation Products And Raw materials

Raw materials

Adenosine, 5'-S-[(3S)-3-amino-3-carboxypropyl]-2',3'-O-(1-methylethylidene)-5'-thio- (9CI) DL-Homocysteine FORMIMINOGLYCINE NLUNILBRZXYZNX-KITWJDSFSA-N 5′-Chloro-5′-deoxy-2′,3′-O-isopropylideneadenosine

L-HOMOCYSTEINE 5'-CHLORO-5'-DEOXYADENOSINE Adenosine Adenosine triphosphate

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Preparation Products

5'-DEOXYADENOSINE

5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE Suppliers

Global( 170)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TopScience Biochemical	00852-68527855	info@itopbiochem.com	China Hong Kong	902	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	86 18062405514 18062405514	ada@ipurechemical.com	CHINA	3465	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	sales@newcanbio.com	China	10026	58

Supplier	Advantage
Hubei Jusheng Technology Co.,Ltd.	58
Standardpharm Co. Ltd.	58
BOC Sciences	58
TopScience Biochemical	58
career henan chemical co	58
Hubei Ipure Biology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	58
Dideu Industries Group Limited	58
NewCan Biotech Limited	58

View Lastest Price from 5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-12-04	5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE 979-92-0	US $0.00-0.00 / kg	0.1kg	98%	100kg	Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
2022-10-11	5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE 979-92-0	US $60.00 / kg	1kg	99%	100 tons	Hebei Duling International Trade Co. LTD
2020-03-05	5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE 979-92-0	US $1.00 / KG	1KG	98% HPLC	10 tons	Career Henan Chemical Co

5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE
979-92-0
US $0.00-0.00 / kg
98%
Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE
979-92-0
US $60.00 / kg
99%
Hebei Duling International Trade Co. LTD

5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE
979-92-0
US $1.00 / KG
98% HPLC
Career Henan Chemical Co

5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE Spectrum

5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE(979-92-0)¹HNMR

979-92-0(5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE)Related Search:

Ademetionine disulfate tosylate L-Cysteine S-Adenosyl-L-methionine S-Adenosyl-L-Methionine-d3 S-Adenosyl-L-Homocysteine-15N4

S-ADENOSYL-L-METHIONINE IODIDE SALT L-HOMOCYSTEINE 5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE Ademetionine 1,4-butanedisulfonate S-ADENOSYL-L-METHIONINE

S-ADENOSYL-L-METHIONINE-D3 (S-METHYL-D3) TETRA(P-TOLUENESULFONATE) SALT 8-Aasm S-ADENOSYL-L-METHIONINE CHLORIDE SALT S-ADENOSYL-L-METHIONINE, [METHYL-14C] 5'-DEOXYADENOSINE

S-Adenosyl-5'-L-methionineSulfate,p-Toluenesulfonate S-ADENOSYL-L-METHIONINE DISULFATE TOSYLATE ADENOSYL-L-METHIONINE, S-[CARBOXYL-14C]

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(2S)-2-amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methylsulfanyl]butanoic acid 5μ-Deoxy-S-adenosyl-L-homocysteine, AdoHcy, S-(5μ-Deoxyadenosine-5μ)-L-homocysteine 5-S'-[(S)-3-Amino-3-carboxypropyl]-5'-thioadenosine Adenosyl-L-homocysteine S-(5′-Adenosyl)-L-homocysteine,5′-Deoxy-S-adenosyl-L-homocysteine, AdoHcy, S-(5′-Deoxyadenosine-5′)-L-homocysteine S-Adenosyl-L-Homocysteine (50 mg) L-5'-S-(3-AMino-3-carboxypropyl)- 5'-thioadenosine L-S-AdenosylhoMocysteine S-(5'-Deoxyadenosin-5'-yl)-L-hoMocysteine AdenosylhoMocysteine-13C5 Adenosyl-L-hoMocysteine-13C5 L-5'-S-(3-AMino-3-carboxypropyl)- 5'-thioadenosine-13C5 L-S-AdenosylhoMocysteine-13C5 S-(5'-Deoxyadenosin-5'-yl)-L-hoMocysteine-13C5 ( 35 ) -5-( 3-AMINO.-3 CARBOXYPROPYL) THIO ) -5-DEOXYADENOSINE S-ADENOSYL-L-HOMOCYSTEINE (ADENOSINE-13C10, 98%) 5'-DEOXY-S-ADENOSYL- -Adenosyl)-L-homocysteine S-(5'-deoxyadenosin-5'-yl) S-(5'-DEOXYADENOSINE-5')-L-HOMOCYSTEINE HOMOCYSTEINE, S-ADENOSYL 5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE (S)-5'-(S)-(3-amino-3-carboxypropyl)-5'-thioadenosine S-(5'-Adenosyl)-L-homocysteine dihydrate Ademetionine 1,4-Butanedisulfonate Impurity 1 SAH (S-Adenosylhomocysteine) L-Homocysteine, S-(5'-deoxyadenosin-5'-yl)- (S)-2-amino-4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)butanoic acid 5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE USP/EP/BP S-(5-Adenosyl)-L-Homocysteine extrapure, 99% Adenosylhomocysteine S-(5'-ADENOSYL)-L-HOMOCYSTEINE S-ADENOSYL-L-HOMOCYSTEINE s-adenosylhomocysteine ADOHCY hpce S-Adenosyl-L-homocystein S-(5'-Adenosyl)-L-homocysteine;AdoHcy;S-(5'-Deoxyadenosine)-L-homocysteine S-(5'-Deoxyadenosine)-L-homocysteine S-Adenosyl-L-Homecysteine inhibit,SAH,Endogenous Metabolite,Inhibitor Butanedisulfonate Ademetionine Impurity (S)-2-Amino-4-[[[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxy-2-tetrahydrofuryl]methyl]thio]butanoic Acid 5'-Deoxy-S-Adenosyl-L-Homocystmine 979-92-0 972-92-0 C14H20N6O5S C14H20N6O5S2H2O A - H BioChemical Amino Acid Library Amino Acids and Peptides Biochemicals and Reagents Metabolic Libraries Metabolomics Modified Amino Acids amino acids Amino Acids & Derivatives