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1-Methyl-1H-indole-4-carbaldehyde

1-Methyl-1H-indole-4-carbaldehyde structure

CAS No.: 133994-99-7

Chemical Name:: 1-Methyl-1H-indole-4-carbaldehyde

Synonyms: 1-Methyl-1H-indole-4-carbaldehyde;1-methyl-1H-indol-4-carboxaldehyde;1H-Indole-4-carboxaldehyde, 1-methyl-;1H-Indole-4-carboxaldehyde, 1-methyl- (9CI);1-methyl-1H-indole-4-carbaldehyde(SALTDATA: FREE)

CBNumber:: CB4589545

Molecular Formula:: C10H9NO

Molecular Weight:: 159.18

MDL Number:: MFCD08690261

MOL File:: 133994-99-7.mol

MSDS File:: SDS

Last updated:2026-09-12 18:52:54

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1-Methyl-1H-indole-4-carbaldehyde Properties

Boiling point	318.7±15.0 °C(Predicted)
Density	1.10±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
Appearance	Light yellow to brown <40°C Solid,>40°C Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H332-H312-H335-H319-H315

Precautionary statements

P280-P302+P352-P312-P322-P363-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312

Hazard Codes

Risk Statements

22-37/38-41

Safety Statements

26-39

HazardClass

IRRITANT

NFPA 704

	1
2		0

1-Methyl-1H-indole-4-carbaldehyde price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	305027	1-Methyl-1H-indole-4-carbaldehyde	133994-99-7	250.00mg	$65	2026-05-19	Buy
Matrix Scientific	305027	1-Methyl-1H-indole-4-carbaldehyde	133994-99-7	1.00g	$128	2026-05-19	Buy
Matrix Scientific	305027	1-Methyl-1H-indole-4-carbaldehyde	133994-99-7	5.00g	$472	2026-05-19	Buy
Synthonix	M53908	1-Methyl-1H-indole-4-carbaldehyde 95+%	133994-99-7	100mg	$80	2026-05-06	Buy
Synthonix	M53908	1-Methyl-1H-indole-4-carbaldehyde 95+%	133994-99-7	250mg	$100	2026-05-06	Buy

Product number	Packaging	Price	Buy
305027	250.00mg	$65	Buy
305027	1.00g	$128	Buy
305027	5.00g	$472	Buy
M53908	100mg	$80	Buy
M53908	250mg	$100	Buy

1-Methyl-1H-indole-4-carbaldehyde Chemical Properties, Uses, Production

Synthesis

1074-86-8

74-88-4

133994-99-7

a) Synthesis of 1-methyl-1H-indole-4-carboxaldehyde: Sodium hydride (171 mg, 60% oil dispersion, 4.27 mmol) was added batchwise to an anhydrous N,N-dimethylformamide (DMF, 6.5 mL) solution of 1H-indole-4-carboxaldehyde (413 mg, 2.85 mmol) under argon protection. The reaction mixture was stirred at room temperature for 40 min. Subsequently, iodomethane (0.36 mL, 5.78 mmol) was slowly added dropwise and the reaction continued to be stirred at room temperature for 12 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (25 mL) and extracted with ethyl acetate (3 x 25 mL). The organic phases were combined, washed sequentially with water (20 mL) and saturated saline (20 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a yellow oily crude product. Purification by silica gel column chromatography (eluent: dichloromethane) gave 1-methyl-1H-indole-4-carboxaldehyde (452 mg, 99% yield) as yellow oil.1H NMR (400 MHz, DMSO-d6) δ 10.20 (s, 1H), 7.84 (d, J = 8.0 Hz, 1H), 7.68 (d, J = 7.2 Hz, 1H), 7.58 (d, J = 7.2 Hz, 1H). 7.58 (d, J = 2.8 Hz, 1H), 7.38-7.34 (m, 1H), 7.08 (d, J = 3.2 Hz, 1H), 3.87 (s, 3H).

References

[1] Patent: WO2007/53131, 2007, A2. Location in patent: Page/Page column 178
[2] European Journal of Medicinal Chemistry, 2017, vol. 134, p. 13 - 23
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 7, p. 2060 - 2079
[4] Journal of Organometallic Chemistry, 2011, vol. 696, # 5, p. 1072 - 1083
[5] Patent: WO2012/47702, 2012, A1. Location in patent: Page/Page column 32

1-Methyl-1H-indole-4-carbaldehyde Preparation Products And Raw materials

Raw materials

Indole-4-carboxaldehyde 1-Methyl-1H-indole-4-carbonitrile 97 Iodomethane Sodium hydride N,N-Dimethylformamide

Preparation Products

(1-Methyl-1H-indol-4-yl)methanol

1-Methyl-1H-indole-4-carbaldehyde Suppliers

Global Suppliers ( 58)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Wuhan TCASChem Technology Co., Ltd.	027-86697669 13986148687	sales@tcaschem.com	China	3990	55
Thermo Fisher Scientific	800-810-5118	cnchemical@thermofisher.com	China	17752	75
9ding chemical ( Shanghai) Limited	4009209199	sales@9dingchem.com	China	22497	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Shanghai YuYuan Pharmaceutical Co., Ltd.	13052276172	product@yuyuanpharm.com	China	401	55
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Taian Jiaye Biotechnology Co.Ltd	15318151873;13127280945	285424065@qq.com	China	9961	55
Beyond Pharmaceutical Co., Ltd	0571-81953185 +86-15381198709	jasonyao@bydpharma.com	China	852	60

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Wuhan Chemwish Technology Co., Ltd	56
Wuhan TCASChem Technology Co., Ltd.	55
Thermo Fisher Scientific	75
9ding chemical ( Shanghai) Limited	55
Bide Pharmatech Ltd.	60
Shanghai YuYuan Pharmaceutical Co., Ltd.	55
Amadis Chemical Company Limited	58
Taian Jiaye Biotechnology Co.Ltd	55
Beyond Pharmaceutical Co., Ltd	60

View Latest Price from 1-Methyl-1H-indole-4-carbaldehyde manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-02	1-METHYL-1H-INDOLE-4-CARBALDEHYDE 133994-99-7	$1.00	1g	99%	200g	Career Henan Chemical Co

1-METHYL-1H-INDOLE-4-CARBALDEHYDE
133994-99-7
$1.00
99%
Career Henan Chemical Co

1-Methyl-1H-indole-4-carbaldehyde Spectrum

1-METHYL-1H-INDOLE-4-CARBALDEHYDE(133994-99-7)¹HNMR

133994-99-7 (1-Methyl-1H-indole-4-carbaldehyde) Related Search:

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1H-Indole-4-carboxaldehyde, 1-methyl- (9CI) 1-methyl-1H-indole-4-carbaldehyde(SALTDATA: FREE) 1-methyl-1H-indol-4-carboxaldehyde 1H-Indole-4-carboxaldehyde, 1-methyl- 1-Methyl-1H-indole-4-carbaldehyde 133994-99-7 ALDEHYDE