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Tacalcitol

Tacalcitol structure

CAS No.: 57333-96-7

Chemical Name:: Tacalcitol

Synonyms: TV 02;C12919;Bonalfa;PRI 2191;Tacalcital;Tacalcitol;Curatoderm;Tacalcitol RS;trans-Calcitriol;1α,24R-Dihydroxyvitamin D3

CBNumber:: CB4875440

Molecular Formula:: C27H44O3

Molecular Weight:: 416.64

MDL Number:

MOL File:: 57333-96-7.mol

Last updated:2023-05-18 11:31:21

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Tacalcitol Properties

Boiling point	565.0±50.0 °C(Predicted)
Density	1.06
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	20mg/mL in DMSO, 20mg/mL in DMF, 20mg/mL in Ethanol
form	Powder
pka	14.43±0.40(Predicted)
CAS DataBase Reference	57333-96-7(CAS DataBase Reference)
FDA UNII	C2W72OJ5ZU
ATC code	D05AX04

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H300
Precautionary statements	P264-P270-P301+P310-P321-P330-P405-P501

Tacalcitol price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SMB00579	Tacalcitol ≥99% (HPLC)	57333-96-7	1MG	$309	2024-03-01	Buy
Cayman Chemical	12079	1,24-dihydroxy Vitamin D3 ≥98%	57333-96-7	1mg	$169	2021-12-16	Buy
Cayman Chemical	12079	1,24-dihydroxy Vitamin D3 ≥98%	57333-96-7	500μg	$89	2021-12-16	Buy
Cayman Chemical	12079	1,24-dihydroxy Vitamin D3 ≥98%	57333-96-7	5mg	$712	2021-12-16	Buy
TRC	T004005	Tacalcitol	57333-96-7	1mg	$320	2021-12-16	Buy

Product number	Packaging	Price	Buy
SMB00579	1MG	$309	Buy
12079	1mg	$169	Buy
12079	500μg	$89	Buy
12079	5mg	$712	Buy
T004005	1mg	$320	Buy

Tacalcitol Chemical Properties,Uses,Production

Description

Tacalcitol, the second vitamin D analog developed as a topical antipsoriatic, was introduced for keratosis, psoriasis, ichthyosis, pityriasis rubra pilaris and palmoplantar pustulosis and keratoderma. It shows improvement in appearance of skin lesions for psoriasis patients without significant side effects. In patients with psoriasis vulgaris, it effectively inhibits keratinocyte growth. Some in vitro studies have shown that tacalcitol inhibits interleukin-1-α-induced granulocyte macrophage colony-stimulating-factor mRNA expression of the human dermal microvascular endothelial cells, which may be involved in mediation of angioproliferation in skin inflammation.

Originator

Teijin (Japan)

Uses

Tacalcitol is a synthetic vitamin D3 analog.

Definition

ChEBI: Tacalcitol is a hydroxy seco-steroid that is calciol which carries hydroxy groups at positions 1S and 24R. It is a vitamin D3 analog which is used for the treatment of psoriasis vulgaris in adults, especially on the scalp. It has a role as an antipsoriatic, a vitamin D receptor agonist and an antineoplastic agent. It is a member of D3 vitamins, a hydroxy seco-steroid, a secondary alcohol and a seco-cholestane. It is functionally related to a calciol.

brand name

Bonalfa

Safety Profile

A poison by ingestion, subcutaneous, and intravenous routes. When heated to decomposition it emits acrid smoke and irritating vapors,

Tacalcitol synthesis

Synthesis of Tacalcitol from 1-(2-Hydroxy-1-methyl-ethyl)-7a-methyl-octahydro-inden-4-ol

Tacalcitol Preparation Products And Raw materials

Raw materials

CALCIUM HYDRIDE Argon Silica gel Potassium tert-butoxide 3-Chloroperoxybenzoic acid

Tetrahydrofuran Lithium Aluminum Hydride

1of2

Preparation Products

Tacalcitol Suppliers

Global( 129)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
HangZhou RunYan Pharma Technology Co.,LTD.	+86-88660901 +86-18112526015	sales@runyanpharma.com	China	326	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	sales@dolonchem.com	CHINA	2972	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Nanjing Shizhou Biotechnology Co., Ltd	+86-15850508050 +86-15850508050	sean.lv@synzest.com	China	323	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Longyan Tianhua Biological Technology Co., Ltd	0086 18039857276 18039857276		CHINA	2783	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	+8617735180244	mike_yan@xuanranglobal.com	CHINA	4022	58

Supplier	Advantage
HangZhou RunYan Pharma Technology Co.,LTD.	58
Capot Chemical Co.,Ltd.	60
Nanjing Dolon Biotechnology Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
career henan chemical co	58
Nanjing Shizhou Biotechnology Co., Ltd	58
TargetMol Chemicals Inc.	58
Longyan Tianhua Biological Technology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	58

View Lastest Price from Tacalcitol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-03-13	Tacalcitol 57333-96-7	US $0.00 / kg	1kg	99.0%min. HPLC	1000kg	HangZhou RunYan Pharma Technology Co.,LTD.
2021-07-13	Tacalcitol 57333-96-7	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09	Tacalcitol 57333-96-7	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Tacalcitol
57333-96-7
US $0.00 / kg
99.0%min. HPLC
HangZhou RunYan Pharma Technology Co.,LTD.

Tacalcitol
57333-96-7
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Tacalcitol
57333-96-7
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

57333-96-7(Tacalcitol)Related Search:

Tacalcitol monohydrate 1,2-DIMETHYLENE-CYCLOHEXANE VitaMin D4 Tacalcitol

(1α，3β-5Z，7E，24R)-9，10-Secoholesta-5，7，10(19)-triene-1，3，24-triol lα，24-Dihydroxycholecalciferol lα，24R-Dihy-droxyvitamin D3 [5Z,7E,24R,(+)]-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,24-triol 1α,24(R)-Dihydroxyvitamin D3 1α,24R-Dihydroxyvitamin D3 (1a,3b,5Z,7E,24R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol C12919 (1α,3β,5Z,7E,24R)-9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol Tacalcital 1α,24(R)-Dihydroxycholecalciferol 4-methylene-5Z-[2E-[(3aS)-octahydro-1R-[4R-hydroxy-1R,5-dimethylhexyl]-7aR-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol Tacalcitol 1-alpha-3-beta-5E,7E,24R)-9,10-Secocholesta-5,7,10,19-triene-1,3,24-triol trans-Calcitriol 1a,24(R)-Dihydroxycholecalciferol 1a,24(R)-Dihydroxyvitamin D3 1a,24R-Dihydroxyvitamin D3 9,10-Secocholesta-5,7,10(19)-triene-1,3,24-triol, (1a,3b,5Z,7E,24R)- (9CI) Bonalfa Curatoderm PRI 2191 TV 02 1ALPHA,24(R)-DIHYDROXYVITAMIND3 TacalcitolQ: What is Tacalcitol Q: What is the CAS Number of Tacalcitol Q: What is the storage condition of Tacalcitol Q: What are the applications of Tacalcitol (1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5R)-5-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,4R)-4-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)- Tacalcitol RS Tacalcitol (1,24(R)-Dihydroxyvitamin D3 (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,5R)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Tacalcitol(1,24-dihydroxy Vitamin D3) 57333-96-7 Vitamin D3 analogs