ChemicalBook
Chinese Japanese Germany Korea

Propranolol hydrochloride

Propranolol hydrochloride
Propranolol hydrochloride structure
CAS No.
318-98-9
Chemical Name:
Propranolol hydrochloride
Synonyms
kemi;Nedis;oposim;tesnol;Cinlol;Ciplar;Elbrol;Herzul;Ikopal;deralin
CBNumber:
CB5112834
Molecular Formula:
C16H22ClNO2
Formula Weight:
295.8
MOL File:
318-98-9.mol

Propranolol hydrochloride Properties

Melting point:
163-165 °C(lit.)
Flash point:
9℃
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL, clear, colorless
form 
powder
color 
white
Water Solubility 
SOLUBLE
Merck 
14,7840
BRN 
4164259
InChIKey
ZMRUPTIKESYGQW-UHFFFAOYSA-N
CAS DataBase Reference
318-98-9(CAS DataBase Reference)
FDA UNII
F8A3652H1V
NCI Dictionary of Cancer Terms
Inderal; propranolol hydrochloride
NCI Drug Dictionary
Inderal
EPA Substance Registry System
Propranolol hydrochloride (318-98-9)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS06,GHS08,GHS07
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370-H302
Precautionary statements  P264-P270-P301+P312a-P330-P501a-P210-P260-P280-P301+P310-P311-P301+P312+P330
Hazard Codes  Xn,Xi,T,F
Risk Statements  22-39/23/24/25-23/24/25-11
Safety Statements  22-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  UB7525000
10
HazardClass  IRRITANT
HS Code  29221990
Toxicity LD50 in mice (mg/kg): 565 orally; 22 i.v.; 107 i.p. (Martin, Linee)
NFPA 704
1
2 1

Propranolol hydrochloride price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P-055 Propranolol hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? 318-98-9 1 mL $28.8 2021-12-16 Buy
Sigma-Aldrich 40543 (±)-Propranolol hydrochloride analytical standard 318-98-9 100mg $64.8 2021-12-16 Buy
Sigma-Aldrich 1576005 Propranolol hydrochloride United States Pharmacopeia (USP) Reference Standard 318-98-9 200mg $366 2021-12-16 Buy
Alfa Aesar H26645 (±)-Propranolol hydrochloride, 99% 318-98-9 5g $68.1 2021-12-16 Buy
Alfa Aesar H26645 (±)-Propranolol hydrochloride, 99% 318-98-9 25g $215 2021-12-16 Buy

Propranolol hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Off-White to Light-Yellow Cyrstalline Solid

Uses

β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).

Uses

For the prophylaxis of migraine

Uses

Propranolol, a β-adrenergic blocker, is most commonly used to reduce blood pressure; treatment of over-active thyroid and some types of tremor; prevention of migraine headaches and some heart-rhythm problems; used to decrease the number of angina attacks (pain from an inadequate oxygen supply to the heart); used after a heart attack to prevent further damage to the heart.

Uses

(±)-Propranolol hydrochloride has been used:
  • to determine whether autonomic nervous system mediated the promotive effect on skin microcirculation in rat
  • as a non-selective β- receptor blocker to reduce the arrhythmogenic events
  • to study its effect on oxygen-induced retinopathy in mice

brand name

Inderal (Wyeth); Innopran (Reliant).

General Description

Propranolol hydrochloride is easily soluble in ethanol and water.

Biochem/physiol Actions

Propranolol hydrochloride is a β-adrenoceptor antagonist. Its action at β2 receptor results in bronchoconstriction. Due to its lipophilic nature, propranolol can penetrate to the central nervous system and has a negative effect. It serves as a 5-HT1/5-HT2 serotonin receptor antagonist. Propranolol hydrochloride is useful as an antihypertensive drug, cardiac depressant and also in the treatment of angina pectoris. It decreases the effect of stress and exercise on heart by reducing the rate of contraction and conduction of impulse. It is known to competitively block the action of catecholamines.

Veterinary Drugs and Treatments

While propranolol is used for hypertension, migraine headache prophylaxis, and angina in human patients, it is used primarily in veterinary medicine for its antiarrhythmic effects. Dysrhythmias treated with propranolol include: atrial premature complexes, ventricular premature complexes, supraventricular premature complexes and tachyarrhythmias, ventricular or atrial tachyarrhythmias secondary to digitalis, atrial tachycardia secondary to Wolff-Parkinson-White (WPW) with normal QRS complexes, and atrial fibrillation (generally in combination with digoxin). Propranolol reportedly improves cardiac performance in animals with hypertrophic cardiomyopathy. It has been used to treat systemic hypertension and clinical signs associated with thyrotoxicosis and pheochromocytoma.

Propranolol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Propranolol hydrochloride Suppliers

Global( 327)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3284 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58

View Lastest Price from Propranolol hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-25 Propranolol hydrochloride
318-98-9
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-12-23 Propranolol hydrochloride
318-98-9
US $100.00 / KG 1g 99% 200kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-09-29 Propranolol hydrochloride
318-98-9
US $0.00 / KG 1KG 98.0% 500kg/month WUHAN FORTUNA CHEMICAL CO., LTD

318-98-9(Propranolol hydrochloride)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved