ChemicalBook >> CAS DataBase List >>N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea structure

CAS No.: 950769-58-1

Chemical Name:: N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea

Synonyms: Quizartinib;CS-53;AC220, AC010220;Quizartinib, >98%;Quizartinib AC-220;AC220 (Quizartinib);AC-220; AC220;QUIZARTINIB;QUIZARTINIB (AC220), >98%;quizartinib (FLT3 inhibitor);AC220 (Quizartinib, AC010220)

CBNumber:: CB52514647

Molecular Formula:: C29H32N6O4S

Molecular Weight:: 560.67

MDL Number:: MFCD18074524

MOL File:: 950769-58-1.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Properties

Density	1.39±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (up to at least 25 mg/ml)
form	White powder.
pka	12.59±0.70(Predicted)
color	Off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
FDA UNII	7LA4O6Q0D3
ATC code	L01EX11

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332-H315-H319-H335
Precautionary statements	P260-P280-P301+P312-P302+P352-P304+P340-P361+P364
HS Code	2914500090

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea price More Price(42)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	17986	Quizartinib ≥98%	950769-58-1	500μg	$29	2024-03-01	Buy
Cayman Chemical	17986	Quizartinib ≥98%	950769-58-1	1mg	$43	2024-03-01	Buy
Cayman Chemical	17986	Quizartinib ≥98%	950769-58-1	5mg	$57	2024-03-01	Buy
Cayman Chemical	17986	Quizartinib ≥98%	950769-58-1	10mg	$85	2024-03-01	Buy
Tocris	6788	Quizartinib ≥98%(HPLC)	950769-58-1	10	$150	2021-12-16	Buy

Product number	Packaging	Price	Buy
17986	500μg	$29	Buy
17986	1mg	$43	Buy
17986	5mg	$57	Buy
17986	10mg	$85	Buy
6788	10	$150	Buy

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Chemical Properties,Uses,Production

Biological activity

Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFRα, PDGFRβ, RET, and CSF-1R. Phase 3.

In vitro

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). AC220 exhibits low nanomolar potency in biochemical and cellular assays and exceptional kinase selectivity high selectivity, but high selectivity when inhibiting most protein kinase of the human. AC220 is a new selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).

In vivo

In a xenograft tumor model, AC220 has nice drug attributes, good efficacy and high tolerability.. AC220 inhibits the activity of FLT3 and significantly extends survival in a mouse model of FLT3-ITD AML. Treatment with AC220 results in eradicating tumors in a xenograft tumor mouse model depended on FLT3. AC220 effectively inhibits the activity of FLT3 in primary cells of patients.

Features

Quizartinib (AC220) is a 2nd-generation FLT3 inhibitor as the first clinical drug candidate.

Description

Quizartinib (950769-58-1) is a potent and selective inhibitor of FLT3 (Kd?= 1.6nM, IC50?= 0.56 nM MV4-11 cells).1?It is in clinical trials for treatment of Acute Myelogenous Leukemia (AML).2,3?Quizartinib priming resulted in prevention of myelosuppression in mice treated with 5-FU and Gemcitabine.4?Quizartinib showed significant reversal of ABCG2-mediated multidrug resistance (@ 3 μM)?via?antagonism of drug efflux function.5,6

Uses

AC 220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).

Definition

ChEBI: A member of the class of ureas that is urea in which one of the amino groups has been substituted by a 5-tert-butyl-1,2-oxazol-3-yl group while the other has been substituted by a phenyl group substituted at the para- position by n imidazo[2,1-b][1,3]benzothiazol-2-yl group that in turn is substituted at position 7 by a 2-(morpholin-4-yl)ethoxy group.

target

Flt3ITD

storage

Store at -20°C

References

1) Chao?et al.?(2009)?Identification of N-(5-tert-butyl-isoxazol-3-yl)-N’-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor; J. Med. Chem.?52?7808 2) Zarrinkar?et al.?(2009);?AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia(AML); Blood?114?2984 3) Fathi and Chen (2017);?The role of FLT3 inhibitors in the treatment of FLT3-mutated acute myeloid leukemia; Eur. J .Haematol.?98?330 4) Taylor and Langdon (2017);?Hitting the snooze button: Inducing quiescence with the FLT3 inhibitor quizartinib protects hematopoietic progenitors from chemotherapy; Mol. Cell Oncol.?4?e1378156 5) Li?et al.?(2017);?Quizartinib (AC220) reverses ABCG2-mediated multidrug resistance: In vitro and In vivo studies; Oncotarget?8?93785 6) Bhullar?et al.?(2013)?The FLT3 inhibitor quizartinib inhibits ABCG2 at pharmacologically relevant concentrations, with implications for both chemosensitization and adverse drug reactions; PLoS One?8?e71266

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Preparation Products And Raw materials

Raw materials

Preparation Products

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Suppliers

Global( 190)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
WinWin Chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	13854	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
WinWin Chemical CO., Limited	58

View Lastest Price from N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-09-23	Quizartinib (AC220) 950769-58-1	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
	2019-07-06	N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea 950769-58-1	US $8.80 / KG	1KG	97%-99%	100kg	Career Henan Chemical Co

Quizartinib (AC220)
950769-58-1
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea
950769-58-1
US $8.80 / KG
97%-99%
Career Henan Chemical Co

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Spectrum

N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea(950769-58-1)¹HNMR

950769-58-1(N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea)Related Search:

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N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea AC-220 quizartinib (FLT3 inhibitor) 1-(5-(tert-Butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)-benzo[d]imidazo[2,1-b]thiazol-2-y Quizartinib AC-220 2-(4-AMinophenyl)-7-(2-Morpholin-4-yl-ethoxy)iMidazo[2,1-b]-[1,3]benzothiazole N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-Morpholin-4-ylethoxy)iMidazo[2,1-b][1,3]benzothiazol-2-yl] AC220 (Quizartinib) AC220 (Quizartinib, AC010220) Urea,N-[5-(1,1-diMethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-Morpholinyl)ethoxy]iMidazo[2,1-b]benzothiazol-2-yl]phenyl]- N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea AC220, AC010220 1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(7-(2- Morpholinoethoxy)benzo[d]iMidazo[2,1-b]thiazol-2-yl)phenyl)urea N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea USP/EP/BP 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-[4-[6-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl]urea Quizartinib, 98%, a uniquely potent and selective Flt3 inhibitor AC-220; AC220;QUIZARTINIB Quizartinib, >98% QUIZARTINIB (AC220), >98% N-[5-(1,1-Dimethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]urea CS-53 Quizartinib 950769-58-1 C29H32N6O4S Inhibitors Anti-cancer Inhibitor Antineoplastic