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JTE-013

CAS No.
383150-41-2
Chemical Name:
JTE-013
Synonyms
CS-2553;JTE-013 HCl;JTE-013;JTE 013;JTE013;LPL Receptor,Apoptosis,JTE-013,Inhibitor,Lysophospholipid Receptor,JTE 013,inhibit,JTE013;1-(2,6-dichloro-4-pyridyl)-3-[(4-isopropyl-1,3-dimethyl-pyrazolo[3,4-b]pyridin-6-yl)amino]urea;1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea;1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide;1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(2,6-dichloro-4-pyridinyl)-semicarbazide;N-(2,6-Dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazine-1-carboxamide;N-(2,6-Dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]hydrazinecarboxamide
CBNumber:
CB52591408
Molecular Formula:
C17H19Cl2N7O
Molecular Weight:
408.29
MDL Number:
MFCD09878275
MOL File:
383150-41-2.mol
MSDS File:
SDS
Last updated:2023-09-04 16:42:00

JTE-013 Properties

Density 1.50±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ≥20mg/mL
pka 9.32±0.43(Predicted)
form powder
color white to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
NFPA 704
0
2 0

JTE-013 price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich J4080 JTE-013 ≥98% (HPLC) 383150-41-2 5mg $155 2024-03-01 Buy
Sigma-Aldrich J4080 JTE-013 ≥98% (HPLC) 383150-41-2 25mg $613 2024-03-01 Buy
Cayman Chemical 10009458 JTE-013 ≥98% 383150-41-2 1mg $26 2024-03-01 Buy
Cayman Chemical 10009458 JTE-013 ≥98% 383150-41-2 5mg $98 2024-03-01 Buy
Cayman Chemical 10009458 JTE-013 ≥98% 383150-41-2 10mg $135 2024-03-01 Buy
Product number Packaging Price Buy
J4080 5mg $155 Buy
J4080 25mg $613 Buy
10009458 1mg $26 Buy
10009458 5mg $98 Buy
10009458 10mg $135 Buy

JTE-013 Chemical Properties,Uses,Production

Description

Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. JTE-013 is a potent, selective sphingosine-1-phosphate 2 (S1P2) receptor antagonist that binds to the human and rat receptors with IC50 values of 17 and 22 nM, respectively, (IC50 values >10 μM for human S1P1 and S1P3). It reverses the inhibitory effects of S1P on cell migration of vascular endothelial cells and smooth muscle cells. Similarly, JTE-013 reverses the inhibition of S1P on invasion and migration of B16 melanoma cells. JTE-013 inhibits S1P-induced contraction of, as well as cyclic AMP accumulation in, coronary artery smooth muscle cells.

Uses

JTE-013 has been used in in vitro blood?brain barrier (BBB) and blood?tumor barrier (BTB) assays.

Definition

ChEBI: 1-(2,6-dichloro-4-pyridinyl)-3-[(1,3-dimethyl-4-propan-2-yl-6-pyrazolo[3,4-b]pyridinyl)amino]urea is a pyrazolopyridine.

Biochem/physiol Actions

JTE-013 can enhance the excitability of small-diameter sensory neurons. It has the ability to repress sphingosine 1-phosphate (S1P)-mediated cellular migration.

storage

Store at +4°C

JTE-013 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 69)Suppliers
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ATK CHEMICAL COMPANY LIMITED
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InvivoChem
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Wuhan Topule Biopharmaceutical Co., Ltd
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Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
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LEAPCHEM CO., LTD.
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Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 132020 58

JTE-013 Spectrum

1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(2,6-dichloro-4-pyridinyl)-semicarbazide 1-(2,6-dichloro-4-pyridyl)-3-[(4-isopropyl-1,3-dimethyl-pyrazolo[3,4-b]pyridin-6-yl)amino]urea 1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(3,5-dichloro-4-pyridinyl)-semicarbazide CS-2553 N-(2,6-Dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]hydrazinecarboxamide JTE-013;JTE 013;JTE013 1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea Hydrazinecarboxamide, N-(2,6-dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]- N-(2,6-Dichloropyridin-4-yl)-2-(4-isopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)hydrazine-1-carboxamide JTE-013 HCl LPL Receptor,Apoptosis,JTE-013,Inhibitor,Lysophospholipid Receptor,JTE 013,inhibit,JTE013 383150-41-2 C17H19Cl2N7O