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UNC2881

UNC2881 Structure
UNC2881 structure
CAS No.
1493764-08-1
Chemical Name:
UNC2881
Synonyms
110849;UNC2881;CS-1177;UNC2881 USP/EP/BP;UNC 2881; UNC-2881;N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrimidine;N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-((trans-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide;N-(4-(1H-iMidazol-1-yl)benzyl)-2-(butylaMino)-4-(((1r,4r)-4-hydroxycyclohexyl)aMino)pyriMidine-5-carboxaMide;2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide;5-Pyrimidinecarboxamide, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-
CBNumber:
CB52715677
Molecular Formula:
C25H33N7O2
Molecular Weight:
463.58
MDL Number:
MFCD28142814
MOL File:
1493764-08-1.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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UNC2881 Properties

Density 1.31±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; insoluble in EtOH; ≥13.55 mg/mL in DMSO
form solid
pka 12.70±0.46(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
NFPA 704
0
2 0

UNC2881 price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29012 UNC2881 1493764-08-1 5mg $106 2024-03-01 Buy
Cayman Chemical 29012 UNC2881 1493764-08-1 50mg $775 2024-03-01 Buy
Cayman Chemical 29012 UNC2881 1493764-08-1 10mg $187 2024-03-01 Buy
Cayman Chemical 29012 UNC2881 1493764-08-1 25mg $414 2024-03-01 Buy
Tocris 6537 UNC2881 ≥98%(HPLC) 1493764-08-1 5 $89 2021-12-16 Buy
Product number Packaging Price Buy
29012 5mg $106 Buy
29012 50mg $775 Buy
29012 10mg $187 Buy
29012 25mg $414 Buy
6537 5 $89 Buy

UNC2881 Chemical Properties,Uses,Production

Description

UNC2881 is an inhibitor of Mer (IC50 = 4.3 nM), a member of the TAM family of receptor tyrosine kinases. It is selective for Mer over the remaining TAM family members Axl and TYRO3 (IC50s = 360 and 250 nM, respectively). UNC2881 inhibits phosphorylation of Mer in 697 B-ALL acute lymphoblastic leukemia cells (IC50 = 21.9 nM). It inhibits platelet aggregation and ATP release induced by type I equine fibrillar collagen in isolated human platelet-rich plasma when used at a concentration of 3 μM.

Uses

UNC2881 is a specific Mer tyrosine kinase inhibitor. It inhibits collagen-stimulated platelet aggregation.

target

Mer tyrosine kinase

storage

Store at +4°C

References

[1]. zhang w, mciver al, stashko ma, et al. discovery of mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. j med chem, 2013, 56(23): 9693-9700.

UNC2881 Preparation Products And Raw materials

Raw materials

Preparation Products

UNC2881 Suppliers

Global( 67)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29067 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Shanghai Hansi Chemical Industry Co., Ltd. 17717618050 zllg@gh-reagent.com China 10424 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2923 55
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
Dideu Industries Group Limited 		58
InvivoChem 		58
LEAPCHEM CO., LTD. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Shanghai Hansi Chemical Industry Co., Ltd. 58
Shanghai Boyle Chemical Co., Ltd. 55

UNC2881 Spectrum

UNC2881(1493764-08-1)1HNMR

1493764-08-1(UNC2881)Related Search:

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UNC 669 UNC0321 UNC-1215 UNC-926 Hydochloride UNC3230
UNC0646 UNC2025 UNC 1079

1of4

2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide UNC2881 N-(4-(1H-iMidazol-1-yl)benzyl)-2-(butylaMino)-4-(((1r,4r)-4-hydroxycyclohexyl)aMino)pyriMidine-5-carboxaMide N-(4-(1H-imidazol-1-yl)benzyl)-2-(butylamino)-4-((1r,4r)-4-hydroxycyclohexylamino)pyrimidine-5-carboxamide UNC2881 N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrimidine 110849 UNC 2881; UNC-2881 CS-1177 5-Pyrimidinecarboxamide, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]- UNC2881 USP/EP/BP N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-((trans-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide UNC 2881,Mer,phosphorylation,inhibit,UNC-2881,orally active,UNC2881,Tyro3,pathologic thrombosis,Axl,Inhibitor,platelet aggregation,TAM Receptor 1493764-08-1 Inhibitors