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2-Chloro-3-methylpyridine

2-Chloro-3-methylpyridine structure

CAS No.: 18368-76-8

Chemical Name:: 2-Chloro-3-methylpyridine

Synonyms: 2-CHLORO-3-METHYLPYRIDINE;2-CHLORO-3-PICOLINE;2-Chloro-3-Pilcoline;2-CHLORO-3-METHYLP...;2-Chloro-3-picoline,98%;2-Choro-3-methypyridine;2-Chlor-3-methylpyridin;2-Chloro-3-mehyl pyridine;2-CHLORO-3-METHYLPYRRIDINE;Pyridine, 2-chloro-3-methyl-

CBNumber:: CB1391806

Molecular Formula:: C6H6ClN

Molecular Weight:: 127.57

MDL Number:: MFCD00234177

MOL File:: 18368-76-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:59:07

Product description	Number	Pack Size	Price
2-Chloro-3-methylpyridine 97%	518948	5ml	$59.4
2-Chloro-3-methylpyridine 97%	518948	25ml	$192
2-Chloro-3-methylpyridine >98.0%(GC)	C1885	5g	$24
2-Chloro-3-methylpyridine >98.0%(GC)	C1885	25g	$79
2-Chloro-3-methylpyridine	C428772	500mg	$45
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2-Chloro-3-methylpyridine Properties

Melting point	193 °C
Boiling point	192-193 °C/751 mmHg (lit.)
Density	1.17 g/mL at 25 °C (lit.)
refractive index	n20/D 1.533(lit.)
Flash point	175 °F
storage temp.	Inert atmosphere,Room Temperature
pka	0.75±0.10(Predicted)
form	Liquid
color	Colorless to light yellow
Specific Gravity	1.170
BRN	107895
InChI	InChI=1S/C6H6ClN/c1-5-3-2-4-8-6(5)7/h2-4H,1H3
InChIKey	RKVUCIFREKHYTL-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=CC=C1C
CAS DataBase Reference	18368-76-8(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS06

Signal word

Warning

Hazard statements

H227-H302+H312+H332-H302-H312-H331-H315-H319-H335

Precautionary statements

P210e-P405-P501a-P210-P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P403+P235-P501-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-20/21/22

Safety Statements

26-36-36/37/39

RIDADR

2810

WGK Germany

HazardClass

6.1

PackingGroup

III

HS Code

29333990

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	2
2		0

2-Chloro-3-methylpyridine price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	518948	2-Chloro-3-methylpyridine 97%	18368-76-8	5ml	$59.4	2022-05-15	Buy
Sigma-Aldrich	518948	2-Chloro-3-methylpyridine 97%	18368-76-8	25ml	$192	2022-05-15	Buy
TCI Chemical	C1885	2-Chloro-3-methylpyridine >98.0%(GC)	18368-76-8	5g	$24	2026-04-30	Buy
TCI Chemical	C1885	2-Chloro-3-methylpyridine >98.0%(GC)	18368-76-8	25g	$79	2026-04-30	Buy
TRC	C428772	2-Chloro-3-methylpyridine	18368-76-8	500mg	$45	2021-12-16	Buy

Product number	Packaging	Price	Buy
518948	5ml	$59.4	Buy
518948	25ml	$192	Buy
C1885	5g	$24	Buy
C1885	25g	$79	Buy
C428772	500mg	$45	Buy

2-Chloro-3-methylpyridine Chemical Properties,Uses,Production

Description

2-Chloro-3-methylpyridine is an intermediate for many medicines and pesticides, such as fluazifop, nicosulfuron, and fluazifop. Moreover, with the gradual promotion of these new high-efficiency and low-toxic heterocyclic pesticides, 2-chloro-3-methylpyridine is increasing. The industrial method for preparing 2-chloro-3-methylpyridine is to obtain it by site-specific chlorination of 3-methylpyridine. First, 3-methylpyridine is epoxidized and then chlorinated. The main chlorinated 3-methylpyridine is a mixture of 2-chloro-3-methylpyridine and 2-chloro-5-methylpyridine, of which 2-chloro-3-methylpyridine accounts for 20% (mass).

Chemical Properties

colorless to light yellow liquid

Uses

2-Chloro-3-methylpyridine is an active ingredient and a major constituent of imidaclopide, a systemic insecticide that acts as insect neurotoxin and belongs to a class of chemical called the neonicotinoids.

Application

2-Chloro-3-methylpyridine can be used as an intermediate for Lumacaftor. Lumacaftor is a drug used to treat certain types of cystic fibrosis, particularly by assisting in the transport of CFTR protein to the cell membrane surface, thereby addressing respiratory issues associated with the disease.

Synthesis

4021-07-2

18368-76-8

General procedure for the synthesis of 2-chloro-3-methylpyridine from 3-methyl-2-pyridinecarboxylic acid: 3-methylpyridine-2-carboxylic acid (56.7 mg, 0.3 mmol), sodium hydroxide (16.0 mg, 0.15 mmol), tetrabutylammonium chloride (TBAC, 26.3 mg, 0.45 mmol) and di-tert-butyl peroxide (DTBP. 165 μL, 0.9 mmol) were placed in a 25 mL Schlenk reaction flask. Subsequently, 1 mL of acetonitrile (CH3CN) was added as a solvent and the reaction mixture was placed in an oil bath at 50 °C for 20 h. The reaction was carried out at a pressure of 1.5 mL. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography using petroleum ether/ethyl acetate as eluent to give 2-chloro-3-methylpyridine in 70% yield.

References

[1] Patent: CN108586334, 2018, A. Location in patent: Paragraph 0048-0050

2-Chloro-3-methylpyridine Preparation Products And Raw materials

Raw materials

3-Methylpyridine-2-carboxylic acid Di-tert-butyl peroxide Sodium hydroxide Tetrabutyl ammonium chloride Acetonitrile

Preparation Products

2-CHLORO-4-METHOXY-3-METHYLPYRIDINE 1-(3-METHYLPYRIDIN-2-YL)PIPERAZINE 2-CHLORO-3-METHYL-4-NITROPYRIDINE N-OXIDE 2-AMINO-4-METHOXYPYRIDINE-3-CARBOXYLIC ACID 2-Chloronicotinic acid

2-CHLORO-3-METHYL-4-METHOXYPYRIDINE N-OXIDE 2-Chloro-5-methylpyridine 2-Chloro-3,6-dimethylpyridine (3-METHYL-PYRIDIN-2-YL)-HYDRAZINE 2-BROMO-3-(CHLOROMETHYL)PYRIDINE

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2-Chloro-3-methylpyridine Suppliers

Global( 389)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Yongzeng Technology Co.,Ltd	+8613818947575	sales@yongzchem.com	China	142	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21590	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58

Supplier	Advantage
Shanghai Yongzeng Technology Co.,Ltd	58
Henan Fengda Chemical Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Shandong chuangyingchemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 2-Chloro-3-methylpyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-01	2-Chloro-3-methylpyridine 18368-76-8	US $0.00 / gm	100gm	99%min	100kgs	Shanghai Yongzeng Technology Co.,Ltd
2025-12-01	2-Chloro-3-methylpyridine 18368-76-8	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-11-18	2-Chloro-3-picoline 18368-76-8	US $1.10 / g	1g	99.00%	100 Tons min	Dideu Industries Group Limited

2-Chloro-3-methylpyridine
18368-76-8
US $0.00 / gm
99%min
Shanghai Yongzeng Technology Co.,Ltd

2-Chloro-3-methylpyridine
18368-76-8
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

2-Chloro-3-picoline
18368-76-8
US $1.10 / g
99.00%
Dideu Industries Group Limited

2-Chloro-3-methylpyridine Spectrum

2-Chloro-3-picoline(18368-76-8)MS 2-Chloro-3-picoline(18368-76-8)¹HNMR 2-Chloro-3-picoline(18368-76-8)¹³CNMR 2-Chloro-3-picoline(18368-76-8)IR1

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2-Chloro-3-(trifluoromethyl)pyridine 2-CHLORO-4,6-DIMETHYLNICOTINAMIDE 2-Chloro-3-cyanopyridine 2,6-Dichloro-4-methylnicotinonitrile 2-Chloro-5-chloromethylpyridine

2-Chloronicotinic acid 2-Chloronicotinamide Difluorochloromethane

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2-CHLORO-3-PICOLINE 2-Chloro-3-methylpyridine, 98+% 2-CHLORO-3-PICOLINE 2-CHLORO-3-METHYLPYRIDINE 2-CHLORO-3-METHYLPYRIDINE (2-CHLORO-3-PICOLINE) 2-CHLORO-3-METHYLPYRIDINE 98% 2-CHLORO-3-METHYLPYRRIDINE 2-Choro-3-methypyridine 2-Chloro-3-picoline,98% 2-Chloro-3-methylpridine ,98% 2-Chloro-3-Pilcoline 2-Chloro-3-mehyl pyridine 2-Chlor-3-methylpyridin 2-Chloro-3-methylpyridine > Pyridine, 2-chloro-3-methyl- 2-Chloro-3-picoline ISO 9001：2015 REACH TIANFUCHEM--18368-76-8--2-Chloro-3-picoline 2-CHLORO-3-METHYLPYRIDINE 2-CHLORO-3-METHYLP... 18368-76-8 C6H6NCl Halogenated Heterocycles Heterocyclic Building Blocks Pyridines Halopyridines Chloropyridines HETERO CHLORIDE Building Blocks alkyl chloride pyridine series Chlorinated heterocyclic series C6Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Boronic Acid Pyridines Chloropyridines Halopyridines Pyridine bc0001