ChemicalBook >> CAS DataBase List >>L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
- CAS No.
- 159190-45-1
- Chemical Name:
- L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
- Synonyms
- L-NIL HCL;L-NIL DIHYDROCHLORIDE;L-N6-(1-Iminoethyl)lysine;OQIBCXRAFAHXMM-KLXURFKVSA-N;L-N6-(1-IMINOETHYL)-LYSINE 2HCL;L-N6-(1-IMINOETHYL)LYSINE, DIHCL;L-Lysine ω-acetamidine dihydrochloride;L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE;LNIL dihydrochloride,L NIL dihydrochloride;N6-(1-IMINOETHYL)-L-LYSINE DIHYDROCHLORIDE
- CBNumber:
- CB5353543
- Molecular Formula:
- C8H18ClN3O2
- Molecular Weight:
- 223.7
- MDL Number:
- MFCD00270890
- MOL File:
- 159190-45-1.mol
Last updated:2023-06-08 09:03:06
| storage temp. | -20°C |
|---|---|
| solubility | DMF: 15 mg/mL; DMSO: 15 mg/mL; Ethanol: 1 mg/mL; PBS: 30 mg/mL; Water: 50 mg/ml |
| form | White to off-white solid. |
| FDA UNII | 8BL5V0T01Y |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I8021 | L-N6-(1-Iminoethyl)lysine dihydrochloride | 159190-45-1 | 10mg | $132 | 2024-03-01 | Buy |
| Cayman Chemical | 80310 | L-NIL (hydrochloride) ≥95% | 159190-45-1 | 10mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 80310 | L-NIL (hydrochloride) ≥95% | 159190-45-1 | 5mg | $9 | 2021-12-16 | Buy |
| Cayman Chemical | 80310 | L-NIL (hydrochloride) ≥95% | 159190-45-1 | 50mg | $148 | 2024-03-01 | Buy |
| Cayman Chemical | 80310 | L-NIL (hydrochloride) ≥95% | 159190-45-1 | 100mg | $276 | 2024-03-01 | Buy |
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Chemical Properties,Uses,Production
Description
L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 μM for iNOS as opposed to 8-38 and 17-92 μM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major.
Uses
L-N6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor:
- to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine
- to study its effects on leptin-induced inflammation in hepatocytes
- to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)
Definition
ChEBI: N(6)-acetimidoyl-L-lysine dihydrochloride is a hydrochloride salt prepared from N(6)-acetimidoyl-L-lysine and two equivalents of hydrogen chloride. A selective inhibitor of inducible nitric oxide synthase. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor. It contains a N(6)-acetimidoyl-L-lysinium(2+).
Biochem/physiol Actions
Selective inhibitor of inducible nitric oxide synthase (iNOS).
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE Suppliers
Global( 25)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 18521732826; | market@aladdin-e.com | China | 25015 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Jiangsu Hongmin Pharmaceutical Co., Ltd. | 18221292452 | fannieliu@glschina.com | China | 6799 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 18768175414 | gaojun@univ-bio.com | China | 24998 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
159190-45-1(L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE)Related Search:
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L-NIL HCL
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L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
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L-Lysine ω-acetamidine dihydrochloride
L-NIL DIHYDROCHLORIDE
OQIBCXRAFAHXMM-KLXURFKVSA-N
L-N6-(1-Iminoethyl)lysine
LNIL dihydrochloride,L NIL dihydrochloride
159190-45-1
Nitric Oxide Synthase
Enzyme Inhibitors
Enzyme Inhibitors by Enzyme
Enzymes, Inhibitors, and Substrates
L to O
BioChemical
Biochemicals and Reagents
Nitric Oxide