1400 W DIHYDROCHLORIDE, 96
- CAS No.
- 214358-33-5
- Chemical Name:
- 1400 W DIHYDROCHLORIDE, 96
- Synonyms
- 1400W2HCl;1400W (hydrochloride);1400 W DIHYDROCHLORIDE, 96;1400W - CAS 214358-33-5 - Calbiochem;N-(3-(aMinoMethyl)benzyl)acetiMidaMide dihydrochloride;N-[3-(AMinoMethyl)benzyl]ethaniMidaMide dihydrochloride;inhibit,1400W dihydrochloride,NO Synthase,NOS,Nitric oxide synthases,1400W,Inhibitor
- CBNumber:
- CB5502105
- Molecular Formula:
- C8H11NO
- Molecular Weight:
- 137.17904
- MDL Number:
- MFCD03428622
- MOL File:
- 214358-33-5.mol
- MSDS File:
- SDS
Melting point | 208 °C |
---|---|
storage temp. | -20°C |
solubility | Soluble in Water (up to 25 mg/ml). |
form | White solid |
color | White |
Water Solubility | Soluble to 100 mM in water |
Stability | Stable for 1 year as supplied. Solutions are not stable. Solutions must be prepared fresh and used within one working day. |
FDA UNII | K1BH573TYJ |
SAFETY
Risk and Safety Statements
Safety Statements | 22-24/25 |
---|---|
WGK Germany | 3 |
HS Code | 29242998 |
1400 W DIHYDROCHLORIDE, 96 price More Price(40)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | W4262 | 1400W dihydrochloride >98%, solid | 214358-33-5 | 10mg | $167 | 2024-03-01 | Buy |
Sigma-Aldrich | 100050 | 1400W | 214358-33-5 | 5mg | $187 | 2024-03-01 | Buy |
Cayman Chemical | 81520 | 1400W (hydrochloride) ≥98% | 214358-33-5 | 5mg | $54 | 2024-03-01 | Buy |
Cayman Chemical | 81520 | 1400W (hydrochloride) ≥98% | 214358-33-5 | 10mg | $98 | 2024-03-01 | Buy |
Cayman Chemical | 81520 | 1400W (hydrochloride) ≥98% | 214358-33-5 | 50mg | $410 | 2024-03-01 | Buy |
1400 W DIHYDROCHLORIDE, 96 Chemical Properties,Uses,Production
Description
1400W (214358-33-5) is a potent, tight-binding, slow inhibitor of inducible nitric oxide synthase (iNOS). Highly selective for iNOS3?(Ki?= 7 nM) over nNOS or eNOS (Ki‘s of 2 μM and 50 μM respectively).1?1400W is cell permeable and active?in vivo.2
Chemical Properties
white to off-white powder
Uses
1400W dihydrochloride has been used:
- as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat
- as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction
- to study its efficacy on renal ischemia/ reperfusion injury in rats
- as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation
Uses
A selective inducible nitric oxide synthase (iNOS) inhibitor. A long-acting human iNOS inhibitor possessing an IC50 value of 2.0uM.
General Description
A selective, cell-permeable, irreversible, slow, tight-binding inhibitor of inducible nitric oxide synthase (iNOS; Kd = 7 nM). Suitable for use in both in vitro and in vivo systems. Has a protective effect against cerebral ischemia by reducing ischemic lesion volumes. Exhibits greater than 5000- and 200-fold potency against human iNOS relative to eNOS and nNOS, respectively, and greater than 1000-fold potency against rat iNOS relative to eNOS.
Biochem/physiol Actions
Cell permeable: yes
storage
Desiccate at RT
References
References/Citations 1) Garvey?et al. (1997),?1400W is a slow, tight-binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo; J. Biol. Chem.,?272?4959 2) Thomsen?et al. (1997),?Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor; Cancer Res.,?57?3300 3) Pigott?et al. (2013),?On the selectivity of neuronal NOS inhibitors; Br. J. Pharmacol.,?168?1255
1400 W DIHYDROCHLORIDE, 96 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9317 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
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