Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]-

Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]- structure

CAS No.: 736945-96-3

Chemical Name:: Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]-

Synonyms: GSK417651A;TRPC3/6-IN-1;(3,4-dihydroisoquinolin-2(1H)-yl)(2-((4-methoxyphenyl)amino)thiazol-4-yl)methanone;Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]-

CBNumber:: CB58346718

Molecular Formula:: C20H19N3O2S

Molecular Weight:: 365.45

MDL Number:

MOL File:: 736945-96-3.mol

Last updated:2023-05-18 11:31:20

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Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]- Properties

Boiling point	579.8±60.0 °C(Predicted)
Density	1.318±0.06 g/cm3(Predicted)
storage temp.	RT (des.)
solubility	Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
form	solid
pka	2.24±0.10(Predicted)
color	Yellow
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
FDA UNII	WV82DEG4YA

Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]- Chemical Properties,Uses,Production

Description

GSK417651A (736945-96-3) is a TRPC blocker. In whole-cell patch-clamp experiments in HEK293 cells transfected with recombinant human TRPC3 or TRPC6, GSK417651A blocked both TRPC3 and TRPC6 current with IC50 of ~0.04 μM.1?Combined pharmacological blockade of TRPC3 and TRPC6 inhibits cardiac hypertrophy.2 Cell permeable

Uses

GSK417651A is an inhibitor of transient receptor channels 3 & 6.

References

1) Xu et al. (2013), Characterization of small molecule TRPC3 and TRPC6 agonists and antagonists; Biophys. J., 104 Supp 1 454a 2) Seo et al. (2014) Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy; Proc. Natl. Acad. Sci. USA, 111 1551

Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]- synthesis

Synthesis of Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]- from 1,2,3,4-TETRAHYDROISOQUINOLINE and 2-(4-METHOXY-PHENYLAMINO)-THIAZOLE-4-CARBOXYLIC ACID

Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]- Preparation Products And Raw materials

Raw materials

2-(4-METHOXY-PHENYLAMINO)-THIAZOLE-4-CARBOXYLIC ACID 1,2,3,4-TETRAHYDROISOQUINOLINE p-Anisidine

Preparation Products

Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]- Suppliers

Global( 4)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8740	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58

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Methanone, (3,4-dihydro-2(1H)-isoquinolinyl)[2-[(4-methoxyphenyl)amino]-4-thiazolyl]- GSK417651A TRPC3/6-IN-1 (3,4-dihydroisoquinolin-2(1H)-yl)(2-((4-methoxyphenyl)amino)thiazol-4-yl)methanone 736945-96-3