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Nitrendipine

Nitrendipine structure

CAS No.: 39562-70-4

Chemical Name:: Nitrendipine

Synonyms: Nitrendipin;3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;Deiten;nidrel;Nitrepin;baye5009;baypress;bayotensin;Bylotensin;NITRENDIPINE

CBNumber:: CB2395104

Molecular Formula:: C18H20N2O6

Molecular Weight:: 360.36

MDL Number:: MFCD00082255

MOL File:: 39562-70-4.mol

MSDS File:: SDS

Last updated:2025-12-05 14:33:18

Product description	Number	Pack Size	Price
Nitrendipine >95%, powder	N144	25mg	$98
Nitrendipine for peak identification European Pharmacopoeia (EP) Reference Standard	Y0001456	10 mg	$156
Nitrendipine >95%, powder	N144	100mg	$323
Nitrendipine European Pharmacopoeia (EP) Reference Standard	N0905000	60 mg	$159
Nitrendipine	N1186	250MG	$62
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Nitrendipine Properties

Melting point	1580C
Boiling point	492.4°C (rough estimate)
Density	1.3595 (rough estimate)
refractive index	1.5700 (estimate)
storage temp.	2-8°C
solubility	methanol: 15 mg/mL
pka	2.79±0.70(Predicted)
form	powder
color	yellow to green
Water Solubility	Soluble in DMSO (17.5 mg/ml), methanol (15 mg/ml), ethyl acetate, and ethanol (25 mM). Insoluble in water.
Stability	Stable for 1 year from date of purchase as supplied. Protect from light. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.
InChI	InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3
InChIKey	PVHUJELLJLJGLN-UHFFFAOYSA-N
SMILES	C1(C)NC(C)=C(C(OC)=O)C(C2=CC=CC([N+]([O-])=O)=C2)C=1C(OCC)=O
CAS DataBase Reference	39562-70-4(CAS DataBase Reference)
FDA UNII	9B627AW319
ATC code	C08CA08
NIST Chemistry Reference	Nitrendipine(39562-70-4)
UNSPSC Code	41116107
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H312-H332

Precautionary statements

P261-P280h-P301+P312a-P304+P340-P321-P501a

Hazard Codes

Risk Statements

20/21/22

Safety Statements

WGK Germany

RTECS

US5653000

Toxicity

LD50 in mice, rats (mg/kg): 39, 12.6 i.v.; 2540, >10000 orally (Hoffmann)

NFPA 704

	0
3		0

Nitrendipine price More Price(49)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N144	Nitrendipine >95%, powder	39562-70-4	25mg	$98	2025-07-31	Buy
Sigma-Aldrich	Y0001456	Nitrendipine for peak identification European Pharmacopoeia (EP) Reference Standard	39562-70-4	10 mg	$156	2025-07-31	Buy
Sigma-Aldrich	N144	Nitrendipine >95%, powder	39562-70-4	100mg	$323	2025-07-31	Buy
Sigma-Aldrich	N0905000	Nitrendipine European Pharmacopoeia (EP) Reference Standard	39562-70-4	60 mg	$159	2025-07-31	Buy
TCI Chemical	N1186	Nitrendipine	39562-70-4	250MG	$62	2025-07-31	Buy

Product number	Packaging	Price	Buy
N144	25mg	$98	Buy
Y0001456	10 mg	$156	Buy
N144	100mg	$323	Buy
N0905000	60 mg	$159	Buy
N1186	250MG	$62	Buy

Nitrendipine Chemical Properties,Uses,Production

Description

Nitrendipine is a vasodilating, dihydropyridine calcium antagonist. Its prolonged therapeutic effect in comparison to nifedipine makes it useful in the once to twice daily treatment of hypertension.

Chemical Properties

Crystalline Solid

Originator

Bayer (W. Germany)

Uses

Antihypertensive;Calcium channel blocker

Uses

Nitrendipine modulates NMDA receptor channel function in mammalian neurons. Nitrendipine has been shown to inhibit neutrophil adhesion to vascular endothelium. It is used in the treatment of primary hypertension to decrease blood pressure. Nitrendipine is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.

Uses

Nitrendipine is a dihydropyridine calcium channel blocker. Nitrendipine is used in the treatment of primary (essential) hypertension to decrease blood pressure. Antihypertensive.

Definition

ChEBI: A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in t e treatment of hypertension.

brand name

Baypress (Bayer);BAYOTENSIN.

General Description

Nitrendipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid methyl ethylester (Baypress), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissue andserves as an effective vasodilator. The drug is used in thetreatment of mild-to-moderate essential hypertension.

Biological Activity

L-type calcium channel blocker.

Biochem/physiol Actions

Ca2+ channel blocker; anti-hypertensive.

storage

Store at RT

References

[1] H. MEYER. ChemInform Abstract: SYNTHESIS AND COMPARATIVE PHARMACOLOGICAL STUDIES OF 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)PYRIDINE-3,5-DICARBOXYLATES WITH NON-IDENTICAL ESTER FUNCTIONS[J]. ChemInform, 1981, 12 27. DOI:10.1002/chin.198127214
[2] K STOEPEL S K A Heise. Pharmacological studies of the antihypertensive effect of nitrendipine.[J]. Arzneimittel-Forschung-Drug Research, 1981, 31 12: 2056-2061.

Nitrendipine synthesis

Synthesis of Nitrendipine from ETHYL 2-ACETYL-3-(3-NITROPHENYL)PROPENOATE and Methyl 3-aminocrotonate

Nitrendipine Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate filter paper Methyl 3-aminocrotonate Methyl acetoacetate 3-Nitrobenzaldehyde

Preparation Products

Ethyl 4-(3-AMinophenyl)-5-(Methoxycarbonyl)-2,6-diMethyl-1,4-dihydropyridine-3-carboxylate

Nitrendipine Suppliers

Global( 482)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan JiyunZen Tech Co., Ltd.	+86-18062099985	Amyjiyunzen@yeah.net	China	672	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21614	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29847	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2161	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58

Supplier	Advantage
Wuhan JiyunZen Tech Co., Ltd.	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Hubei Jusheng Technology Co.,Ltd.	58
Accela ChemBio Inc.	58
Xiamen AmoyChem Co., Ltd	58
HubeiwidelychemicaltechnologyCo.,Ltd	58
Shandong chuangyingchemical Co., Ltd.	58
Standardpharm Co. Ltd.	58

View Lastest Price from Nitrendipine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-08	Nitrendipine 39562-70-4	US $1.00 / g	1g	98.5~101.5%,BP2010	10kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2025-12-08	Nitrendipine 39562-70-4	US $5.00-0.50 / KG	1KG	99% hplc	500TONS	Wuhan JiyunZen Tech Co., Ltd.
2025-12-05	Nitrendipine 39562-70-4	US $32.00-65.00 / mg		99.55%	10g	TargetMol Chemicals Inc.

Nitrendipine
39562-70-4
US $1.00 / g
98.5~101.5%,BP2010
WUHAN FORTUNA CHEMICAL CO., LTD

Nitrendipine
39562-70-4
US $5.00-0.50 / KG
99% hplc
Wuhan JiyunZen Tech Co., Ltd.

Nitrendipine
39562-70-4
US $32.00-65.00 / mg
99.55%
TargetMol Chemicals Inc.

Nitrendipine Spectrum

Nitrendipine(39562-70-4)¹HNMR

39562-70-4(Nitrendipine)Related Search:

Nimodipine 1-(2,6-Dimethylphenoxy)-2-propanamine Nitrendipine Propyl Ester M-NIFEDIPINE 5-(Ethoxycarbonyl)-2-(hydroxyMethyl-6-Methyl-4-(3-nitrophenyl)nicotinic Acid

Nifedipine Impurity F NSC 136464 Dehydronitrendipine Nisoldipine Iganidipine

Pranidipine Benidipine Palonidipine S(+)-NIGULDIPINE HYDROCHLORIDE Nilvadipine

3,5-Pyridinedicarboxylic acid 4-(3-Nitrophenyl)pyridine EPN

1of4

NITRENDIPINE 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacidethy baye5009 bayotensin baypress ethylmethyl1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxy 2，6-Dimethyl-4-(3-nitrophenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl ethyl ester Bylotensin Deiten 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, ethyl methyl ester (9CI) Nitrepin Ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 5-ethyl 3-methyl ester 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl 5-methyl ester 3-ethyl 5-Methyl (4R)-2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Lercanidipine Ethyl Methyl Ester IMpurity (IMpurity 5) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester Nitrendipine for peak identification (RS)-Methylethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate lmethylester nidrel ylmethylester ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(meta-nitrophenyl)-3,5-pyridinedicarboxylate 1,4-DIHYDRO-2,6-DIMETHYL-4-(3'-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL METHYL ESTER 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL METHYL ESTER NITRENDIPINE >95% CA2+ CHANNEL BLOCKER, NITRENDIPINE EPN(CRM STANDARD) (NITROPHENYLPYRIDINE ANALOGUE) EPN(CRM STANDARD) NITRENDIPINE IMPURITY AETHYL METHYL-2,6-DIMETHYL-4-(3-NITROPHENYL) PYRIDINE-3,5-DICARBOXYLATE NITRENDIPINE MM(CRM STANDARD) Nitrendipine, ≥95.0% Group horizon Nitrendipine for system suitability CRS Nitrendipine CRS 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-ethyl 5-methyl ester 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Ethyl Methyl Ester Ethyl Methyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate Nitrendipine USP/EP/BP Nitrendipiner Nitrendipine, Pharma Lercanidipine methyl ethyl ester imp Nitrendipine (BAY-E-5009) Nitrendipine Impurity1218 Lercanidipine Ethyl Methyl Ester Impurity Nitrendipine D5Q: What is Nitrendipine D5 Q: What is the CAS Number of Nitrendipine D5 Q: What is the storage condition of Nitrendipine D5 NitrendipineQ: What is Nitrendipine Q: What is the CAS Number of Nitrendipine Q: What is the storage condition of Nitrendipine Q: What are the applications of Nitrendipine Nitrendipin 3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Group of horizon Nitrendipine in methanol Nitrendipine, L-type Ca2+ channel blocker Nitrendipine, 10 mM in DMSO (RS)-Methyl ethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate - EP Grade Nitrendipine 100 μg/mL in Acetonitrile 39562-70-4 C18H20N2O6 36036 Calcium Channel Modulators