PKSI 527
- CAS No.
- 128837-71-8
- Chemical Name:
- PKSI 527
- Synonyms
- PKSI 527,PKSI527;2-[4-[[(2S)-2-[[4-(aminomethyl)cyclohexanecarbonyl]amino]-3-phenylpropanoyl]amino]phenyl]aceticacid,hydrochloride;2-(4-((S)-2-(trans-4-(Aminomethyl)cyclohexane-1-carboxamido)-3-phenylpropanamido)phenyl)acetic acid hydrochloride;Benzeneacetic acid, 4-[[(2S)-2-[[[trans-4-(aminomethyl)cyclohexyl]carbonyl]amino]-1-oxo-3-phenylpropyl]amino]-, hydrochloride (1:1)
- CBNumber:
- CB61393901
- Molecular Formula:
- C25H31N3O4.ClH
- Molecular Weight:
- 473.998
- MDL Number:
- MFCD01745772
- MOL File:
- 128837-71-8.mol
PKSI 527 price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23974 | PKSI-527 ≥95% | 128837-71-8 | 5mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 23974 | PKSI-527 ≥95% | 128837-71-8 | 25mg | $505 | 2024-03-01 | Buy |
| AK Scientific | 6192CJ | 2-[4-[[(2S)-2-[[4-(Aminomethyl)cyclohexanecarbonyl]amino]-3-phenylpropanoyl]amino]phenyl]aceticacid;hydrochloride | 128837-71-8 | 5mg | $233 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000084 | PKSI-527 95.00% | 128837-71-8 | 5MG | $503.38 | 2021-12-16 | Buy |
PKSI 527 Chemical Properties,Uses,Production
Description
PKSI-527 (128837-71-8) is a selective plasma kallikrein inhibitor (Ki = 0.81 μM)1 that can be used for affinity purification of kallikrein2.? Synergizes with NO donors to produce antithrombic effects ex-vivo.3? Suppresses collagen-induced arthritis in mouse models.4
References
Wanaka et al. (1992), Synthesis of trans-4-aminomethylcyclohexanecarbonyl-L- and –D-phenylalanine-4-carboxymethylanilide and examination of their inhibitory activity against plasma kallikrein;? ?Chem. Pharm. Bull., 40 1814 Tada et al. (2001), Isolation of plasma kallikrein by high efficiency affinity chromatography and its characterization; Chem. Pharm. Bull., 24 520 Ikarugi et al. (2005), Synergistic antithrombotic effect of a combination of NO donor and plasma kallikrein inhibitor; Thromb. Res., 116 403 Fujimori et al. (1993), Effects of a highly selective plasma kallikrein inhibitor on collagen-induced arthritis in mice; Agents Actions, 39 42
PKSI 527 Preparation Products And Raw materials
Raw materials
Preparation Products
PKSI 527 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 61720 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Shanghai Jieshikai Biotechnology Co. , Ltd. | 021-57520305 15801958784 | lihua@jskchem.com | China | 49036 | 58 |