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1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE

1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE structure

CAS No.: 112037-78-2

Chemical Name:: 1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE

Synonyms: -carboline;3-Methyl αNorharmane (9H-Pyrido[3,4-b]indole, ß1,2,3,4-Tetrahydro-1-(trifluoromethyl)-ßrac 1-Trichloromethyl-1,2,3,4-Tetrahydro-β(S)-1-Trichloromethyl-1,2,3,4-Tetrahydro-β1,2,3,4-Tetrahydro-1-(trifluoroMethyl)--carboline;1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE;1,2,3,4-TETRAHYDRO-1-(TRIFLUOROMETHYL)-BETA-CARBOLINE;1-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-beta-carboline

CBNumber:: CB6140573

Molecular Formula:: C12H11F3N2

Molecular Weight:: 240.22

MDL Number:: MFCD00052089

MOL File:: 112037-78-2.mol

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1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Properties

Melting point	147-149°C
Boiling point	350.0±37.0 °C(Predicted)
Density	1.351±0.06 g/cm3(Predicted)
pka	16.63±0.40(Predicted)

SAFETY

Risk and Safety Statements

Risk Statements	36/37/38
Safety Statements	26-36/37/39

1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	HCH0016529	1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE 95.00%	112037-78-2	5MG	$501.91	2021-12-16	Buy

Product number	Packaging	Price	Buy
HCH0016529	5MG	$501.91	Buy

1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Chemical Properties,Uses,Production

Mechanism of action

Although βCCE and other β-carbolines are not endogenous BZR ligands (vide supra) and are not currently approved for clinical use, they are used to characterize different GABAA/BZR subtypes (based on a and g subunit composition) and function (e.g., the partial agonist abecarnil) toward the discovery of anxioselective drugs. In this regard, the β-carboline ring system is planar in comparison to the boat conformation of the 1,4-benzodiazepines; thus, β-carbolines have been useful to extend structure–activity relationship information for the agonist, antagonist, and inverse agonist pharmacophores of the various GABAA/BZR subtypes.

Clinical Use

Several β-carbolines have approximately 10-fold higher affinity for the BZR when compared to diazepam. The ethyl ester of β-carboline-3-carboxylic acid (βCCE), identified in human urine extracts as an artifact of the extraction procedure, has very high affinity for the BZR.

1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE synthesis

Synthesis of 1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE from Tryptamine and TRIFLUOROACETALDEHYDE ETHYL HEMIACETAL

1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Preparation Products And Raw materials

Raw materials

TRIFLUOROACETALDEHYDE ETHYL HEMIACETAL Tryptamine

Preparation Products

1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Suppliers

Global( 13)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Hangzhou Yuhao Chemical Technology Co., Ltd	0571-82693216	info@yuhaochemical.com	China	9394	52
United States Biological	--	sales@advtechind.com	United States	6106	58

Supplier	Advantage
Career Henan Chemica Co	58
Hangzhou Yuhao Chemical Technology Co., Ltd	52
United States Biological	58

112037-78-2(1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE)Related Search:

N-(4-CHLORO-3-NITROPHENYL)-1-(TRIFLUOROMETHYL)-1,3,4,9-TETRAHYDRO-2H-BETA-CARBOLINE-, TECH 2,3,3-TRICHLORO-1-[1-(TRIFLUOROMETHYL)-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLIN-2-YL]PROP-2-EN-1-ONE 1-(P-CHLOROBENZYL)-2,3,4,9-TETRAHYDRO-1-(TRIFLUOROMETHYL)-1H-B-CARBOLINE N-(4-CHLORO-3-NITROPHENYL)-1-(TRIFLUOROMETHYL)-1,3,4,9-TETRAHYDRO-2H-BETA-CARBOLINE-2-CARBOXAMIDE 1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE

2-CHLORO-1-[1-(TRIFLUOROMETHYL)-1,3,4,9-TETRAHYDRO-2H-BETA-CARBOLIN-2-YL]ETHAN-1-ONE 2,3,4,9-TETRAHYDRO-1-(P-NITROBENZYL)-1-(TRIFLUOROMETHYL)-1H-B-CARBOLINE

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-carboline 1-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-beta-carboline 1,2,3,4-Tetrahydro-1-(trifluoromethyl)-ß 1,2,3,4-Tetrahydro-1-(trifluoroMethyl)--carboline 1-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole 1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE 1,2,3,4-TETRAHYDRO-1-(TRIFLUOROMETHYL)-BETA-CARBOLINE (S)-1-Trichloromethyl-1,2,3,4-Tetrahydro-&beta rac 1-Trichloromethyl-1,2,3,4-Tetrahydro-&beta 3-Methyl &alpha 1-trifluoromethyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole Norharmane (9H-Pyrido[3,4-b]indole, ß 1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-1-(trifluoromethyl)- 2,3,4,9-Tetrahydro-1-(trifluoromethyl)-1H-pyrido[3,4-b]indole 112037-78-2 pharmacetical