1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE
- CAS No.
- 112037-78-2
- Chemical Name:
- 1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE
- Synonyms
- -carboline;3-Methyl αNorharmane (9H-Pyrido[3,4-b]indole, ß1,2,3,4-Tetrahydro-1-(trifluoromethyl)-ßrac 1-Trichloromethyl-1,2,3,4-Tetrahydro-β(S)-1-Trichloromethyl-1,2,3,4-Tetrahydro-β1,2,3,4-Tetrahydro-1-(trifluoroMethyl)--carboline;1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE;1,2,3,4-TETRAHYDRO-1-(TRIFLUOROMETHYL)-BETA-CARBOLINE;1-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-beta-carboline
- CBNumber:
- CB6140573
- Molecular Formula:
- C12H11F3N2
- Molecular Weight:
- 240.22
- MDL Number:
- MFCD00052089
- MOL File:
- 112037-78-2.mol
SAFETY
Risk and Safety Statements
Risk Statements | 36/37/38 |
---|---|
Safety Statements | 26-36/37/39 |
1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Chemical Properties,Uses,Production
Mechanism of action
Although βCCE and other β-carbolines are not endogenous BZR ligands (vide supra) and are not currently approved for clinical use, they are used to characterize different GABAA/BZR subtypes (based on a and g subunit composition) and function (e.g., the partial agonist abecarnil) toward the discovery of anxioselective drugs. In this regard, the β-carboline ring system is planar in comparison to the boat conformation of the 1,4-benzodiazepines; thus, β-carbolines have been useful to extend structure–activity relationship information for the agonist, antagonist, and inverse agonist pharmacophores of the various GABAA/BZR subtypes.
Clinical Use
Several β-carbolines have approximately 10-fold higher affinity for the BZR when compared to diazepam. The ethyl ester of β-carboline-3-carboxylic acid (βCCE), identified in human urine extracts as an artifact of the extraction procedure, has very high affinity for the BZR.
1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Preparation Products And Raw materials
1-TRIFLUOROMETHYL-2,3,4,9-TETRAHYDRO-1H-B-CARBOLINE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
Hangzhou Yuhao Chemical Technology Co., Ltd | 0571-82693216 | info@yuhaochemical.com | China | 9394 | 52 |
United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |
Supplier | Advantage |
---|---|
Career Henan Chemica Co | 58 |
Hangzhou Yuhao Chemical Technology Co., Ltd | 52 |
United States Biological | 58 |
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