(S)-1-Boc-3-hydroxypiperidine
- CAS No.
- 143900-44-1
- Chemical Name:
- (S)-1-Boc-3-hydroxypiperidine
- Synonyms
- tert-butyl (S)-3-hydroxypiperidine-1-carboxylate;(S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;Ibrutinib Interm 0441;1,1-DiMethylethy;(S)-BOC-piperidinol;Ilutinib impurity 7;(S)-1-BOC-3-PIPERIDINOL;(S)-N-BOC-3-piperidinol;(S)-1-BOC-Piperidin-3-ol;(S)-1-Boc-3-hydroxypiperi...
- CBNumber:
- CB6197360
- Molecular Formula:
- C10H19NO3
- Molecular Weight:
- 201.26
- MDL Number:
- MFCD06659041
- MOL File:
- 143900-44-1.mol
- MSDS File:
- SDS
Melting point | 34-40 °C |
---|---|
Boiling point | 292.3±33.0 °C(Predicted) |
Density | 1.107±0.06 g/cm3(Predicted) |
Flash point | 110 °C |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Soluble in methanol. |
pka | 14.74±0.20(Predicted) |
form | Powder or Crystalline Powder |
color | White to tan |
optical activity | [α]22/D +10.0°, c = 1 in chloroform |
InChI | InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m0/s1 |
InChIKey | UIJXHKXIOCDSEB-QMMMGPOBSA-N |
SMILES | N1(C(OC(C)(C)C)=O)CCC[C@H](O)C1 |
CAS DataBase Reference | 143900-44-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36/37/39 | |||||||||
WGK Germany | 3 | |||||||||
HS Code | 29339900 | |||||||||
NFPA 704 |
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(S)-1-Boc-3-hydroxypiperidine price More Price(38)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 687367 | (S)-1-Boc-3-hydroxypiperidine 97% | 143900-44-1 | 1g | $112 | 2024-03-01 | Buy |
TCI Chemical | B4446 | (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC) | 143900-44-1 | 1g | $21 | 2024-03-01 | Buy |
TCI Chemical | B4446 | (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC) | 143900-44-1 | 5g | $64 | 2024-03-01 | Buy |
Alfa Aesar | H52771 | (S)-1-Boc-3-hydroxypiperidine, 97% | 143900-44-1 | 1g | $50.65 | 2024-03-01 | Buy |
Alfa Aesar | H52771 | (S)-1-Boc-3-hydroxypiperidine, 97% | 143900-44-1 | 5g | $207.65 | 2024-03-01 | Buy |
(S)-1-Boc-3-hydroxypiperidine Chemical Properties,Uses,Production
Uses
(S)-1-Boc-3-hydroxypiperidine is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies. Synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma.
Description
(S)-1-Boc-3-hydroxypiperidine, alias (S)-N-Boc-3-hydroxypiperidine (S-NBHP) is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies.S-NBHP can be prepared in a variety of ways such as chemically or biocatalytically. S-NBHP can be prepared in various ways, such as chemical synthesis or biocatalysis. Biocatalysis is an efficient process for the reduction of N-Boc-piperidin-3-one by recombinant keto reductase (KRED) catalytic to obtain optically pure S-NBHP using 99% yield. The asymmetric reduction of N-Boc-piperidin-3-one (NBPO) to (S)-NBHP can also be catalysed by a reductase (YDR541C) isolated from Saccharomyces cerevisiae in 99% yield.
Chemical Properties
White powder
Uses
A piperidine derivative with an amine protecting group, (S)-1-Boc-3-hydroxypiperidine can be used in the preparation of biologically active compounds such as antagonists of the human P2X7 receptor and selective irreversible inhibitors for bruton's tyrosine kinase.
Uses
(S)-1-Boc-3-hydroxypiperidine is used as pharmaceutical intermediate.
(S)-1-Boc-3-hydroxypiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
SyncoZymes (Shanghai) Co., Ltd., | +86-021-68187180-811 +86-13681683526 | lchen@syncozymes.com | China | 188 | 58 |
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd. | +86-18616643091 +86-18616643091 | info@rochipharma.com | China | 246 | 58 |
Lianhe Aigen Pharmatech Co.,Ltd. | +undefined+undefined18918657159 | sales-Aigen@lianhetech.com | China | 314 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 990 | 58 |
Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 +86-17332992504 | sales8@hbganmiao.com | China | 300 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21666 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9285 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
Related articles
- Uses and Preparation of (S)-1-Boc-3-hydroxypiperidine
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- Jul 11,2022
View Lastest Price from (S)-1-Boc-3-hydroxypiperidine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-25 | (S)-1-Boc-3-hydroxypiperidine
143900-44-1
|
US $63.00-308.00 / g | 100g | 0.99 | 100kg | Shanghai UCHEM Inc. | ||
2024-08-20 | (S)-1-Boc-3-hydroxypiperidine
143900-44-1
|
US $10.00-7.00 / kg | 1kg | 99.9% | 20ton | Hebei Ganmiao New material Technology Co., LTD | ||
2023-11-01 | (S)-1-Boc-3-hydroxypiperidine
143900-44-1
|
US $0.00-0.00 / kg | 1kg | 99.9% | 20 tons | Hangzhou ICH Biofarm Co., Ltd |
- (S)-1-Boc-3-hydroxypiperidine
143900-44-1
- US $63.00-308.00 / g
- 0.99
- Shanghai UCHEM Inc.
- (S)-1-Boc-3-hydroxypiperidine
143900-44-1
- US $10.00-7.00 / kg
- 99.9%
- Hebei Ganmiao New material Technology Co., LTD
- (S)-1-Boc-3-hydroxypiperidine
143900-44-1
- US $0.00-0.00 / kg
- 99.9%
- Hangzhou ICH Biofarm Co., Ltd