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2,6-Difluoropyridine

2,6-Difluoropyridine Structure
2,6-Difluoropyridine structure
CAS No.
1513-65-1
Chemical Name:
2,6-Difluoropyridine
Synonyms
2,6-DifL;2,6-difluoropyridi;2,6-Difluorpyridin;2,6-DIFLUOROPYRIDINE;2,6-Difuloropyridine;Pyridine, 2,6-difluoro-;2,6-Difluoropyridine99%;2,6-Difluoropyridine 99%;2, 6-2 fluoride pyridine;2,6-Difluoropyridine >
CBNumber:
CB6210492
Molecular Formula:
C5H3F2N
Molecular Weight:
115.08
MDL Number:
MFCD00006227
MOL File:
1513-65-1.mol
MSDS File:
SDS
Last updated:2026-05-28 02:55:51
Product description Number Pack Size Price
2,6-Difluoropyridine 99% 233277 5g $51.4
2,6-Difluoropyridine 99% 233277 25g $132
2,6-Difluoropyridine >98.0%(GC) D1741 5g $34
2,6-Difluoropyridine >98.0%(GC) D1741 25g $95
2,6-Difluoropyridine ≥98% CS-W013627 25g $32
More product size
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2,6-Difluoropyridine Properties

Boiling point 124.5 °C/743 mmHg (lit.)
Density 1.268 g/mL at 25 °C (lit.)
refractive index n20/D 1.437(lit.)
Flash point 93 °F
storage temp. Inert atmosphere,2-8°C
solubility Not miscible or difficult to mix.
form Liquid
pka -6.09±0.10(Predicted)
Specific Gravity 1.268
color Clear purple-red
BRN 1422549
Dielectric constant 107.8
InChI 1S/C5H3F2N/c6-4-2-1-3-5(7)8-4/h1-3H
InChIKey MBTGBRYMJKYYOE-UHFFFAOYSA-N
SMILES Fc1cccc(F)n1
CAS DataBase Reference 1513-65-1(CAS DataBase Reference)
FDA UNII Y58NXZ62TV
NIST Chemistry Reference 2,6-Difluoropyridine(1513-65-1)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Warning
Hazard statements  H226-H315-H319-H335
Precautionary statements  P210-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,T,F
Risk Statements  10-36/37/38
Safety Statements  16-26-36/37/39-37/39
RIDADR  UN 1993 3/PG 3
WGK Germany  3
F  10
Hazard Note  Toxic
HazardClass  3
PackingGroup  III
HS Code  29333999
Storage Class 3 - Flammable liquids
Hazard Classifications Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
3
2 0

2,6-Difluoropyridine price More Price(60)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 233277 2,6-Difluoropyridine 99% 1513-65-1 5g $51.4 2026-04-30 Buy
Sigma-Aldrich 233277 2,6-Difluoropyridine 99% 1513-65-1 25g $132 2026-04-30 Buy
TCI Chemical D1741 2,6-Difluoropyridine >98.0%(GC) 1513-65-1 5g $34 2026-04-30 Buy
TCI Chemical D1741 2,6-Difluoropyridine >98.0%(GC) 1513-65-1 25g $95 2026-04-30 Buy
ChemScene CS-W013627 2,6-Difluoropyridine ≥98% 1513-65-1 25g $32 2026-06-04 Buy
Product number Packaging Price Buy
233277 5g $51.4 Buy
233277 25g $132 Buy
D1741 5g $34 Buy
D1741 25g $95 Buy
CS-W013627 25g $32 Buy

2,6-Difluoropyridine Chemical Properties,Uses,Production

Chemical Properties

Colorless to light yellow liquid

Uses

2,6-Difluoropyridine has been used in the preparation of poly(pyridine ether)s via polycondensation with silylated 1,1,1-tris(4-hydroxyphenyl)ethane.

General Description

Lithium diisopropylamide (LDA)-mediated ortholithiations of 2,6-difluoropyridine in tetrahydrofuran at -78°C has been studied using a combination of IR and NMR spectroscopic and computational methods. Polycondensation of bistrimethylsilyl derivatives of various diphenols with 2,6-difluoropyridine in N-methylpyrrolidone in the presence of K2CO3 has been investigated.

Synthesis

2,6-Dichloropyridine

2402-78-0

2,6-Difluoropyridine

1513-65-1

General procedure for the synthesis of 2,6-difluoropyridine from 2,6-dichloropyridine: In a desiccator, accurately weigh anhydrous NMe4F (18.6 mg, 0.2 mmol, 2 eq.) and 2,6-dichloropyridine (0.1 mmol, 1 eq.) in a 4 mL vial fitted with a microstirring bar. DMF (0.5 mL) was added, the vial was removed from the desiccator, and the reaction was stirred at room temperature for 24 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and the internal standard (1,3,5-trifluorobenzene, 100 μL 0.5 M toluene solution) was added. Aliquots were taken for 59F NMR spectroscopy and GC-MS analysis.

References

[1] Patent: US4071521, 1978, A
[2] Angewandte Chemie - International Edition, 2006, vol. 45, # 17, p. 2720 - 2725
[3] Organic Letters, 2015, vol. 17, # 8, p. 1866 - 1869
[4] Journal of Organic Chemistry, 2015, vol. 80, # 24, p. 12137 - 12145
[5] Patent: WO2017/24167, 2017, A1. Location in patent: Page/Page column 29; 33; 35

2,6-Difluoropyridine Preparation Products And Raw materials

Raw materials

2-Fluoropyridine 2,6-Dichloropyridine Pyridine Tetramethylammonium fluoride N,N-Dimethylformamide

Preparation Products

6-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONITRILE 1-(2,6-DIFLUOROPYRIDIN-3-YL)PROPAN-1-ONE 2-Amino-6-fluoropyridine 6-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID 2,6-Difluoropyridine-3-boronic acid
N-(6-FLUORO-3-FORMYLPYRIDIN-2-YL)PIVALAMIDE 2,6-Dichloropyridine 2,6-Difluoro-3-nitropyridine 3-Bromo-2,6-difluoropyridine 2-Chloropyridine
Acetamide, N-(6-fluoro-2-pyridinyl)- (9CI)

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2,6-Difluoropyridine Suppliers

Global( 416)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20111 58
Frapp's ChemicalNFTZ Co., Ltd. 		+86 (576) 8169-6106 sales@frappschem.com China 877 50
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14032 58
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 809 58
Dongfan Chem. Co., Ltd. 		021-34500607 13391355195 sales@dfanchem.com CHINA 61 55
Fluoropharm Co., Ltd. 		+86-0571-85586753 +86-13336034509 sales@fluoropharm.com China 1444 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10399 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8491 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Frapp's ChemicalNFTZ Co., Ltd. 		50
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Hi-Tech Chemistry Corp 		58
Dongfan Chem. Co., Ltd. 		55
Fluoropharm Co., Ltd. 		60
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58

View Lastest Price from 2,6-Difluoropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,6-Difluoropyridine pictures 2026-08-13 2,6-Difluoropyridine
1513-65-1
 $8.00 1KG 99% Henan Fengda Chemical Co., Ltd
2,6-Difluoropyridine pictures 2025-06-25 2,6-Difluoropyridine
1513-65-1
 $1.10 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
2,6-Difluoropyridine pictures 2025-04-04 2,6-Difluoropyridine
1513-65-1
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

2,6-Difluoropyridine Spectrum

2,6-Difluoropyridine(1513-65-1)MS2,6-Difluoropyridine(1513-65-1)1HNMR2,6-Difluoropyridine(1513-65-1)IR12,6-Difluoropyridine(1513-65-1)Raman

1513-65-1(2,6-Difluoropyridine)Related Search:

2,5-Dimethylpyridine Flupirtine DIPIPERIDINOMETHANE 2-Chloro-5-chloromethylpyridine 2,6-Lutidine
2,5-PYRIDINEDICARBOXYLIC ACID Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 4-AMINO-3-CHLORO-2,5,6-TRIFLUOROPYRIDINE 2,3,5,6-TETRAFLUORO-4-PYRIDINE-CARBONITRILE 3,5-Dichloro-2,4,6-trifluoropyridine
3-Chloro-2,4,5,6-tetrafluoropyridine 3,5-DIFLUOROPYRIDINE 2,5-DIFLUOROPYRIDINE 2,4-DIFLUORO-PYRIDINE 2,3,5,6-Tetrafluoropyridine
4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE 4-Amino-3,5-dichloro-2,6-difluoropyridine 2,3-DIFLUOROPYRIDINE

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2,6-Difluoropyridine, 99% 5GR 2,6- twofluorine pyridine 2,6-Difluoropyridine, 97+% 2, 6-2 fluoride pyridine 2,6-difluoropyridi 2,6-DIFLUOROPYRIDINE Pyridine, 2,6-difluoro- 2,6-Difluoropyridine, 95+% 2,6-Difluoropyridine 99% 2,6-Difluoropyridine99% 2,6-DIFLUOROPYRIDINE, 98+% 2,6-Difuloropyridine 2,6-Difluorpyridin 2,6-DifL 2,6-Difluoropyridine > 2,6-Difluoropyridine ISO 9001：2015 REACH 2,6-Difluoropyridine 98.5% 1513-65-1 1513-65-7 216-152-8 C5F2H3N1 C5 Building Blocks Fluoropyridines Halopyridines Heterocyclic Building Blocks Pyridines Fluorine series Building Blocks Chemical Synthesis Fluorinated Building Blocks Heterocyclic Building Blocks Heterocyclic Fluorinated Building Blocks Other Fluorinated Heterocycles Pyridines, Pyrimidines, Purines and Pteredines Fluorin-contained pyridine series C5 Heterocyclic Building Blocks Pyridine Pyridines Fluoropyridines Halopyridines bc0001