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NPGB

NPGB structure

CAS No.: 19135-17-2

Chemical Name:: NPGB

Synonyms: NPGB;PNPGB;Nsc163801;P-NITROPHENYL P'-GUANIDINOBENZOATE HCL;4-NITROPHENYL 4-GUANIDINOBENZOATE &;4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE;P-NITROPHENYL-P-GUANIDINOBENZOATE HYDROCHLORIDE;P-NITROPHENYL P'-GUANIDINOBENZOATE HYDROCHLORIDE;p-nitrophenyl-p'-guanidinobenzoateHClcrystalline;4-GUANIDINOBENZOIC ACID 4-NITROPHENYL-ESTER HYDROCHLORIDE

CBNumber:: CB6287205

Molecular Formula:: C14H13ClN4O4

Molecular Weight:: 336.73

MDL Number:: MFCD00037010

MOL File:: 19135-17-2.mol

Last updated:2024-01-02 12:08:44

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NPGB Properties

Melting point	241-243 °C
storage temp.	-20°C
BRN	8024554

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05
Signal word	Danger
Hazard statements	H318
Precautionary statements	P280-P305+P351+P338
Hazard Codes	Xi
Risk Statements	36
Safety Statements	26
WGK Germany	3
F	8-10

NPGB price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N8010	4-Nitrophenyl 4-guanidinobenzoate hydrochloride protease inhibitor and substrate	19135-17-2	500mg	$284	2024-03-01	Buy
Sigma-Aldrich	N8010	4-Nitrophenyl 4-guanidinobenzoate hydrochloride protease inhibitor and substrate	19135-17-2	1g	$506	2024-03-01	Buy
American Custom Chemicals Corporation	CHM0114939	4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE 95.00%	19135-17-2	500MG	$719.17	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0114939	4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE 95.00%	19135-17-2	1G	$999.36	2021-12-16	Buy

Product number	Packaging	Price	Buy
N8010	500mg	$284	Buy
N8010	1g	$506	Buy
CHM0114939	500MG	$719.17	Buy
CHM0114939	1G	$999.36	Buy

NPGB Chemical Properties,Uses,Production

Uses

4-Nitrophenyl 4-guanidinobenzoate hydrochloride has been used:

as a substrate for trypsin for active site titration experiments
for pre-treating of mosquito eggs in the interplasmid transposition assay
as a component of isotonic buffer to moisten filter paper for mosquito embryo collection

General Description

4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) is a trypsin substrate. It is more water-soluble than 4-methylumbelliferyl 4-guanidinobenzoate and is preferred in spectrophotometric assay.

Biochem/physiol Actions

4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) inhibits phenoloxidase enzyme and delays embryo chorionic membrane hardening.

References

[1] BHUMI PATEL . L. donovani XPRT: Molecular characterization and evaluation of inhibitors[J]. Biochimica et biophysica acta. Proteins and proteomics, 2018, 1866 3: Pages 426-441. DOI:10.1016/j.bbapap.2017.12.002.
[2] FRANK S. STEVEN Margaret M G. Studies on the Molecular Mechanism of Mersalyl and 4-Aminophenylmercuric Acetate Re-activation of Trypsin-Thiol Complexes[J]. The FEBS journal, 1980, 109 2: 567-573. DOI:10.1111/j.1432-1033.1980.tb04829.x.
[3] YING-YING HE . Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra venom[J]. Peptides, 2008, 29 10: Pages 1692-1699. DOI:10.1016/j.peptides.2008.05.025.
[4] J.A. SCHIFFERLI G. S. A simple two-step procedure for the preparation of the first component of human complement (C1) in its native form[J]. Journal of immunological methods, 1985, 76 2: Pages 283-288. DOI:10.1016/0022-1759(85)90305-9.
[5] J. M. KAMINSKI. Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates[J]. Journal of Medicinal Chemistry, 1986, 29 4: 514-519. DOI:10.1021/jm00154a015.

NPGB Preparation Products And Raw materials

Raw materials

Preparation Products

NPGB Suppliers

Global( 14)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Beijing Haite lesk Technology Co., Ltd	15210893940; 15116916250	chemistryliu@163.com	China	7327	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58
Shaanxi Dideu Newmaterial Co., Ltd.	029-63373950 15353716720	1052@dideu.com	China	10011	58
Shanghai Yingxin laboratory equipment Co., Ltd	021-021-59178156 15300768757	359382369@qq.com	China	10678	58
Shanghai Guchen Biotechnology Co., LTD	021-34675735 19147740836	1986399151@qq.com	China	9849	58

Supplier	Advantage
Sigma-Aldrich	80
Beijing Haite lesk Technology Co., Ltd	58
Energy Chemical	58
Shaanxi Dideu Newmaterial Co., Ltd.	58
Shanghai Yingxin laboratory equipment Co., Ltd	58
Shanghai Guchen Biotechnology Co., LTD	58

19135-17-2(NPGB)Related Search:

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METHYL 4-AMINOBENZOATE HYDROCHLORIDE 4-(PHENOXYMETHYL)ANILINE 4-nitrophenyl 4'-guanidinobenzoate

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4-GUANIDINOBENZOIC ACID 4-NITROPHENYL-ESTER HYDROCHLORIDE 4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE NPGB PNPGB P-NITROPHENYL P'-GUANIDINOBENZOATE HYDROCHLORIDE P-NITROPHENYL-P-GUANIDINOBENZOATE HYDROCHLORIDE P'-GUANIDINOBENZOIC ACID P-NITROPHENYL ESTER HYDROCHLORIDE Nsc163801 4-nitrophenyl 4-[(aminoiminomethyl)amino]benzoate monohydrochloride P-NITROPHENYL P'-GUANIDINOBENZOATE HCL 4-NITROPHENYL 4-GUANIDINOBENZOATE & p-nitrophenyl-p'-guanidinobenzoateHClcrystalline p-Nitrophenyl-p'-guanidinobenzoatehydrochloridecrystalline Benzoic acid, 4-(aminoiminomethyl)amino-, 4-nitrophenyl ester, monohydrochloride 4-Guanidinobenzoic acid 4-nitrophenylester hydrochloride, NPGB, pNPGB (4-nitrophenyl)4-(diaminomethylideneamino)benzoate,hydrochloride 4-Nitrophenyl 4-guanidinobenzoate hydrochloride protease inhibitor and substrate 19135-17-2 C14H12N4O4HCl Substrates by Enzyme Chromogenic Enzymes, Inhibitors, and Substrates Enzyme Substrates Activity BioChemical Biochemicals and Reagents