ChemicalBook >> CAS DataBase List >>HKI 357
HKI 357
- CAS No.
- 848133-17-5
- Chemical Name:
- HKI 357
- Synonyms
- HKI 357;Inhibitor,HKI-357,ErbB-1,HER1,inhibit,NSCLCs,Epidermal growth factor receptor,HKI 357,EGFR,ERBB2,HKI357;(2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide;2-Butenamide, N-[4-[[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-
- CBNumber:
- CB63037308
- Molecular Formula:
- C31H29ClFN5O3
- Molecular Weight:
- 574.05
- MDL Number:
- MFCD26792555
- MOL File:
- 848133-17-5.mol
Last updated:2023-09-04 15:51:00
| Boiling point | 747.6±60.0 °C(Predicted) |
|---|---|
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| form | Powder |
| pka | 12.37±0.43(Predicted) |
| FDA UNII | 39R3638KZ6 |
HKI 357 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 14847 | HKI 357 ≥98% | 848133-17-5 | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 14847 | HKI 357 ≥98% | 848133-17-5 | 5mg | $239 | 2024-03-01 | Buy |
| Cayman Chemical | 14847 | HKI 357 ≥98% | 848133-17-5 | 10mg | $323 | 2024-03-01 | Buy |
| Tocris | 3580 | HKI357 ≥98%(HPLC) | 848133-17-5 | 50 | $956 | 2021-12-16 | Buy |
| Tocris | 3580 | HKI357 ≥98%(HPLC) | 848133-17-5 | 10 | $227 | 2021-12-16 | Buy |
HKI 357 Chemical Properties,Uses,Production
Biological Activity
HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 with IC50 of 34 nM and 33 nM, respectively. It can inhibit EGFR autophosphorylation (detected at Y1068), and AKT and MAPK phosphorylation.
in vitro
HKI-357 (0.01-10 μM) is effective in suppressing ligand-induced EGFR autophosphorylation and its downstream signaling, as determined by AKT and MAPK phosphorylation in NCI-H1975 cells. HKI-357 is also effective in suppressing EGFR autophosphorylation (measured at residue Y1068), and AKT and MAPK phosphorylation in parental NCI-H1650 cells harboring the delE746-A750 EGFR mutation.
Western Blot Analysis
| Cell Line: | NCI-H1975 bronchoalveolar cell line |
| Concentration: | 0.01, 0.01, 0.1, 1 and 10 μM |
| Incubation Time: | |
| Result: | Suppressed ligand-induced EGFR autophosphorylation and its downstream signaling AKT and MAPK phosphorylation. |
target
| EGFR 34 nM (IC 50 ) | ErbB2 33 nM (IC 50 ) |
HKI 357 Preparation Products And Raw materials
Raw materials
Preparation Products
HKI 357 Suppliers
Global( 31)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4182 | 55 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9833 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 3614 | 58 |
HKI 357
2-Butenamide, N-[4-[[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-
(2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide
Inhibitor,HKI-357,ErbB-1,HER1,inhibit,NSCLCs,Epidermal growth factor receptor,HKI 357,EGFR,ERBB2,HKI357
848133-17-5
C31H29ClFN5O3