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Calcium phosphate dibasic

Chemical Properties Uses Preparation
Calcium phosphate dibasic
Calcium phosphate dibasic structure
CAS No.
7757-93-9
Chemical Name:
Calcium phosphate dibasic
Synonyms
Monetite;MAGGRAN(R) CP;MAGNESIA 85500;Calcium dibasic;DICALCIUM PHOSPHATE;ANHYDROUS EMCOMPRESS;calciumphosphate(1:1);MONOCALCIUM PHOSPHATE;CALCIUMPHOSPHATEGLASS;CALCIUM ORTHOPHOSPHATE
CBNumber:
CB6344120
Molecular Formula:
CaHO4P
Formula Weight:
136.06
MOL File:
7757-93-9.mol

Calcium phosphate dibasic Properties

Melting point:
370°C(decomposition)
Density 
2.306(16℃)
RTECS 
TB8528000
storage temp. 
2-8°C
solubility 
Practically insoluble in water and in ethanol (96 per cent). It dissolves in dilute hydrochloric acid and in dilute nitric acid.
form 
gel (aged)
color 
White
PH
7 (10g/l, H2O, 20°C) suspension
Water Solubility 
Sparingly soluble in water, practically insoluble in cold water.
Merck 
13,1697
Solubility Product Constant (Ksp)
pKsp: 7
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
FUFJGUQYACFECW-UHFFFAOYSA-L
Substances Added to Food (formerly EAFUS)
CALCIUM PHOSPHATE, DIBASIC
SCOGS (Select Committee on GRAS Substances)
Calcium phosphate dibasic
FDA 21 CFR
181.29
CAS DataBase Reference
7757-93-9(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
L11K75P92J
EPA Substance Registry System
Calcium hydrogen phosphate (7757-93-9)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25-22
WGK Germany  3
TSCA  Yes
HS Code  2835 25 00
Toxicity LD50 orally in Rabbit: 10000 mg/kg LD50 dermal Rabbit > 7940 mg/kg
NFPA 704
0
1 1

Calcium phosphate dibasic price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 21177 Calcium phosphate dibasic puriss. p.a., anhydrous, >98.5% (KT) 7757-93-9 50g-f $51.8 2019-12-02 Buy
Sigma-Aldrich 1.02144 Calcium hydrogen phosphate anhydrous extra fine powder EMPROVE? ESSENTIAL Ph Eur,BP,USP,FCC,E 341 (ii) 7757-93-9 1 kg $125 2021-03-22 Buy
Sigma-Aldrich C7263 Calcium phosphate dibasic 98.0-105.0% 7757-93-9 2.5kg $186 2021-03-22 Buy
Sigma-Aldrich 1.02144 Calcium hydrogen phosphate anhydrous extra fine powder EMPROVE? ESSENTIAL Ph Eur,BP,USP,FCC,E 341 (ii) 7757-93-9 25 kg $770 2021-03-22 Buy
Alfa Aesar 040232 Calcium hydrogen phosphate, anhydrous, 98% min 7757-93-9 5kg $311 2021-03-22 Buy

Calcium phosphate dibasic Chemical Properties,Uses,Production

Chemical Properties

Dibasic Calcium Phosphate is anhydrous or contains two molecules of water of hydration. It occurs as a white, odorless, tasteless powder that is stable in air. It is practically insoluble in water, but is readily soluble in dilute hydrochloric and nitric acids. It is insoluble in alcohol.
Dibasic Calcium Phosphate
Dibasic calcium phosphate is produced by the reaction of phosphoric acid, calcium chloride, and sodium hydroxide. Calcium carbonate can be used in place of the calcium chloride and sodium hydroxide.
Dibasic calcium phosphate anhydrous is generally regarded as relatively nontoxic and nonirritant material. It is widely used in oral pharmaceutical products and food products.
Functional Use in Foods: Leavening agent; dough conditioner; nutrient; dietary supplement; yeast food.

Uses

Dibasic calcium phosphate is found in nature as the mineral monetite. It is used as a food supplement and source of calcium, both in human food and animal feed. It is used in dough conditioner; in several dental products and in medicine. Other applications are in fertilizers, plastics and in the manufacture of glass.

Preparation

Dibasic calcium hydrogen phosphate may be prepared by several methods.
It is precipitated by mixing solutions of calcium chloride and disodium hydrogen phospate: CaCl2 + Na2HPO4 → CaHPO4 + 2NaCl
It also is prepared by treating phosphoric acid with lime water (suspension of calcium hydroxide in water). Also, it is obtained as a by-product in the preparation of hydroxypatite. The preparation involves the reaction of phosphoric acid with calcium phosphate.
H3PO4 + Ca3(PO4)2 → 3CaHPO4

Chemical Properties

Anhydrous dibasic calcium phosphate is a white, odorless, tasteless powder or crystalline solid. It occurs as triclinic crystals.

Physical properties

White triclinic crystal; density 2.92 g/cm3 (anhydrous) and 2.31 g/cm3 (dihy drate); hardness 3.5 Mohs; decomposes on heating; inosluble in water and alcohol; KSP 2.7x10-7; soluble in dilute mineral acid.

Uses

Replenisher (calcium); pharmaceutic aid (tablet base).

Production Methods

Calcium phosphates are usually prepared by reacting very pure phosphoric acid with calcium hydroxide, Ca(OH)2 obtained from limestone, in stoichiometric ratio in aqueous suspension followed by drying at a temperature that will allow the correct hydration state to be achieved. After drying, the coarse-grade material is obtained by means of a classification unit; the fine particle-size material is obtained by milling. Dibasic calcium phosphate, anhydrous, may also be prepared by spray-drying.

brand name

CalStar (FMC); D.C.P. (Parke-Davis).

Pharmaceutical Applications

Anhydrous dibasic calcium phosphate is used both as an excipient and as a source of calcium in nutritional supplements. It is used particularly in the nutritional/health food sectors. It is also used in pharmaceutical products because of its compaction properties, and the good flow properties of the coarse-grade material. The predominant deformation mechanism of anhydrous dibasic calcium phosphate coarse-grade is brittle fracture and this reduces the strain-rate sensitivity of the material, thus allowing easier transition from the laboratory to production scale. However, unlike the dihydrate, anhydrous dibasic calcium phosphate when compacted at higher pressures can exhibit lamination and capping. This phenomenon can be observed when the material represents a substantial proportion of the formulation, and is exacerbated by the use of deep concave tooling. This phenomenon also appears to be independent of rate of compaction.
Anhydrous dibasic calcium phosphate is abrasive and a lubricant is required for tableting, for example 1% w/w magnesium stearate or 1% w/w sodium stearyl fumarate.
Two particle-size grades of anhydrous dibasic calcium phosphate are used in the pharmaceutical industry. Milled material is typically used in wet-granulated or roller-compacted formulations. The ‘unmilled’ or coarse-grade material is typically used in directcompression formulations.
Anhydrous dibasic calcium phosphate is nonhygroscopic and stable at room temperature. It does not hydrate to form the dihydrate.
Anhydrous dibasic calcium phosphate is used in toothpaste and dentifrice formulations for its abrasive properties.

Agricultural Uses

Dicalcium phosphate (CaHPO4) is made from calcium carbonate and phosphoric acid. It contains 34% citrate- soluble phosphorus pentoxide (P2O5). It is not commonly used as a fertilizer, but is used as a supplement to animal feed.

Safety Profile

Skin and eye irritant. A nuisance dust.

Safety

Dibasic calcium phosphate anhydrous is widely used in oral pharmaceutical products, food products, and toothpastes, and is generally regarded as a relatively nontoxic and nonirritant material.

storage

Dibasic calcium phosphate anhydrous is a nonhygroscopic, relatively stable material. Under conditions of high humidity it does not hydrate to form the dihydrate.
The bulk material should be stored in a well-closed container in a dry place.

Purification Methods

Crystallise it from a near-saturated solution in 50% aqueous reagent grade phosphoric acid at 100o by filtering through fritted glass and cooling to room temperature. The crystals are filtered off, and this process is repeated three times using fresh acid. For the final crystallisation the solution is cooled slowly with constant stirring to give thin plate crystals that are filtered off on a fritted glass funnel, washed free of acid with anhydrous acetone and dry in a vacuum desiccator [Egan et al.J Am Chem Soc 78 1811 1956].

Incompatibilities

Dibasic calcium phosphate should not be used to formulate tetracyline antibiotics.
The surface of milled anhydrous dibasic calcium phosphate is alkaline and consequently it should not be used with drugs that are sensitive to alkaline pH. However, reports suggest there are differences in the surface alkalinity/acidity between the milled and unmilled grades of anhydrous dibasic calcium phosphate; the unmilled form has an acidic surface environment. This difference has important implications for drug stability, particularly when reformulating from, e.g. roller compaction to direct compression, when the particle size of the anhydrous dibasic calcium phosphate might be expected to change.
Dibasic calcium phosphate dihydrate has been reported to be incompatible with a number of drugs and excipients, and many of these incompatibilities are expected to occur with dibasic calcium phosphate, anhydrous; see Calcium phosphate, dibasic dihydrate.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Calcium phosphate dibasic Preparation Products And Raw materials

Raw materials

Preparation Products


Calcium phosphate dibasic Suppliers

Global( 297)Suppliers
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View Lastest Price from Calcium phosphate dibasic manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-07 Calcium phosphate dibasic
7757-93-9
US $20.00 / Kg/Drum 25Kg/Drum 99.99% 1 ton per week Wuhan Mulei New Material Technology Co. Ltd
2021-08-26 Dicalcium phosphate
7757-93-9
US $2.60 / KG 1KG 75% 5000kg Hebei Crovell Biotech Co Ltd
2021-08-18 Calcium phosphate dibasic
7757-93-9
US $1.10 / g 1g 99% 20tons Hebei Binshare New Material Co. Ltd

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