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CALCIUM PHOSPHATE TRIBASIC

CALCIUM PHOSPHATE TRIBASIC
CALCIUM PHOSPHATE TRIBASIC structure
CAS No.
12167-74-7
Chemical Name:
CALCIUM PHOSPHATE TRIBASIC
Synonyms
Si-HAp;ALPHA-TCP;Einecs 235-330-6;TRI-CALCIUM PHOSPHATE;TERT-CALCIUM PHOSPHATE;CALCIUM ORTHOPHOSPHATE;CELLULOSE HYDROXYAPATIT;APATITE FAP, HEXACLINIC;Cellulose hydroxyapatite;BETA-TRICALCIUM PHOSPHATE
CBNumber:
CB9131093
Molecular Formula:
5Ca.3O4P.HO
Formula Weight:
502.31
MOL File:
12167-74-7.mol

CALCIUM PHOSPHATE TRIBASIC Properties

Melting point:
1100 °C(lit.)
Density 
1.038 g/mL at 25 °C
storage temp. 
2-8°C
solubility 
Soluble in 1 M Hydrochloric acid.
form 
aqueous suspension
color 
White
PH
4-6
Water Solubility 
Partially soluble in water.
Merck 
1694
CAS DataBase Reference
12167-74-7(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280a-P305+P351+P338-P321-P332+P313-P337+P313-P261-P304+P340-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25-22
WGK Germany  3
TSCA  Yes
HS Code  2835260000

CALCIUM PHOSPHATE TRIBASIC price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 289396 Hydroxyapatite reagent grade, powder, synthetic 12167-74-7 25g $108 2018-11-13 Buy
Sigma-Aldrich 1087031 Tribasic calcium phosphate United States Pharmacopeia (USP) Reference Standard 12167-74-7 1g $386 2018-11-13 Buy
Alfa Aesar 036731 Calcium phosphate tribasic, 34-40% Ca 12167-74-7 10kg $254 2018-11-16 Buy
Alfa Aesar 036731 Calcium phosphate tribasic, 34-40% Ca 12167-74-7 2kg $91.4 2018-11-16 Buy
Sigma-Aldrich C5267 Calcium phosphate tribasic 34.0-40.0% Ca basis 12167-74-7 100g $96.5 2018-11-20 Buy

CALCIUM PHOSPHATE TRIBASIC Chemical Properties,Uses,Production

Chemical Properties

col hexagonal crystal(s) [CRC10]

Chemical Properties

The PhEur 6.4 states that tribasic calcium phosphate consists of a mixture of calcium phosphates. It contains not less than 35.0% and not more than the equivalent of 40.0% of calcium. The USP32– NF27 specifies that tribasic calcium phosphate consists of variable mixtures of calcium phosphates having the approximate composition 10CaO·3P2O5·H2O. This corresponds to a molecular formula of Ca5(OH)(PO4)3 or Ca10(OH)2(PO4)6.
Tribasic calcium phosphate is a white, odorless and tasteless powder.

Uses

Si-substituted hydroxyapatite (Si-HAp) nanopowder can be incorporated in biodegradable polymer composites or deposited on biocompatible surfaces similar to pure HAp nanopowder (cat. no. 677418). Biological activity of HAp was shown to be enhanced by substitution of silicon ions into a fraction of HAp lattice phosphate sites.1,2

Uses

Hydroxyapatite nanopowders, incorporated in biodegradable polymer composites1 or deposited on biocompatible substrates,2 have been shown to promote adhesions and proliferation of bone-forming (osteoblast) cells.

Production Methods

Tribasic calcium phosphate occurs naturally as the minerals hydroxylapatite, voelicherite, and whitlockite. Commercially, it is prepared by treating phosphate-containing rock with sulfuric acid. Tribasic calcium phosphate powder is then precipitated by the addition of calcium hydroxide. Tribasic calcium phosphate is alternatively prepared by treating calcium hydroxide from limestone with purified phosphoric acid. It may also be obtained from calcined animal bones. Some tribasic calcium phosphate products may be prepared in coarser, directly compressible forms by granulating the powder using roller compaction or spray drying.

Pharmaceutical Applications

Tribasic calcium phosphate is widely used as a capsule diluent and tablet filler/binder in either direct-compression or wet-granulation processes. The primary bonding mechanism in compaction is plastic deformation. As with dibasic calcium phosphate, a lubricant and a disintegrant should usually be incorporated in capsule or tablet formulations that include tribasic calcium phosphate. In some cases tribasic calcium phosphate has been used as a disintegrant.It is most widely used in vitamin and mineral preparations as a filler and as a binder. It is a source of both calcium and phosphorus, the two main osteogenic minerals for bone health. The bioavailability of the calcium is well known to be improved by the presence of cholecalciferol. Recent research reports that combinations of tribasic calcium phosphate and vitamin D3 are a cost-effective advance in bone fracture prevention.
In food applications, tribasic calcium phosphate powder is widely used as an anticaking agent.

Safety

Tribasic calcium phosphate is widely used in oral pharmaceutical formulations and food products, and is generally regarded as nontoxic and nonirritant at the levels employed as a pharmaceutical excipient.
Ingestion or inhalation of excessive quantities may result in the deposition of tribasic calcium phosphate crystals in tissues. These crystals may lead to inflammation and cause tissue lesions in the areas of deposition.
Oral ingestion of very large quantities of tribasic calcium phosphate may cause abdominal discomfort such as nausea and vomiting.
No teratogenic effects were found in chicken embryos exposed to a dose of 2.5 mg of tribasic calcium phosphate.
LD50 (rat, oral): >1 g/kg

storage

Tribasic calcium phosphate is a chemically stable material, and is also not liable to cake during storage.
The bulk material should be stored in a well-closed container in a cool, dry place.

Incompatibilities

All calcium salts are incompatible with tetracycline antibiotics. Tribasic calcium phosphate is incompatible with tocopheryl acetate (but not tocopheryl succinate). Tribasic calcium phosphate may form sparingly soluble phosphates with hormones.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

CALCIUM PHOSPHATE TRIBASIC Preparation Products And Raw materials

Raw materials

Preparation Products


CALCIUM PHOSPHATE TRIBASIC Suppliers

Global( 74)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21668 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1861 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8921 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76

View Lastest Price from CALCIUM PHOSPHATE TRIBASIC manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-10 CALCIUM PHOSPHATE TRIBASIC
12167-74-7
US $1.00 / KG 1KG 99% 25kg career henan chemical co

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