TASIN-1 hydrochloride
- CAS No.
- 1678515-13-3
- Chemical Name:
- TASIN-1 hydrochloride
- Synonyms
- TASIN1 HCl;TASIN 1 HCl;TASIN-1 HCl;TASIN-1 hydrochloride;TASIN-1 hydrochloride >=98% (HPLC);TASIN 1 Hydrochloride,TASIN1 Hydrochloride
- CBNumber:
- CB67245941
- Molecular Formula:
- C18H29ClN2O3S
- Molecular Weight:
- 388.95
- MDL Number:
- MFCD31697721
- MOL File:
- 1678515-13-3.mol
TASIN-1 hydrochloride Chemical Properties,Uses,Production
Description
TASIN-1 (1678515-13-3) selectively induces apoptosis in cells with truncations in the adenomatous polyposis coli (APC) gene (but not normal cells or wild type cancer cells), an important multifunctional tumor suppressor gene.1 IC50 = 70nM for DLD1 cell line.? It inhibited cancer cell growth in human tumor xenografts (DLD1 and HT29 tumors) and a genetically engineered mouse model (CPC;Apc) of colorectal cancer.? TASIN-1 induces ER stress-dependent JNK activation with ROS production and AKT inhibition via cholesterol depletion.2
References
Zhang et al. (2016), Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer; Sci. Transl. Med., 8 361ra140 Zhang et al. (2016), Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells; Mol. Cancer Ther., 17 943
TASIN-1 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
TASIN-1 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 3616 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6749 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |