ailanthone
- CAS No.
- 981-15-7
- Chemical Name:
- ailanthone
- Synonyms
- ailanthone;Δ13-Dehydrochaparrinone;13,21-Didehydrochaparrinone;2H-1,11c-(Epoxymethano)phenanthro[10,1-bc]pyran-5,10(3H,6aH);(1beta,11alpha,12alpha)-1,11,12-trihydroxy-11,20-epoxypicras...;11β,20-Epoxy-1β,11,12α-trihydroxypicrasa-3,13(21)-diene-2,16-dione;(1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione;Picrasa-3,13(21)-diene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-, (1b,11b,12a)-;Picrasa-3,13(21)-diene-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-, (1β,11β,12α)-;(1R,2R,3aS,3a1S,6aR,7aS,11S,11aS,11bR)-1,2,11-Trihydroxy-8,11a-dimethyl-3-methylene-2,3,3a,4,7,7a,11,11a-octahydro-1H-1,3a1-(epoxymethano)dibenzo[de,g]chromene-5,10(6aH,11bH)-dione
- CBNumber:
- CB71327541
- Molecular Formula:
- C20H24O7
- Molecular Weight:
- 376.4
- MDL Number:
- MFCD01729487
- MOL File:
- 981-15-7.mol
- MSDS File:
- SDS
Melting point | 235-237 °C |
---|---|
Boiling point | 641.0±55.0 °C(Predicted) |
Density | 1.47 |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | DMSO:100.0(Max Conc. mg/mL);265.67(Max Conc. mM) |
form | A crystalline solid |
pka | 11.85±0.70(Predicted) |
color | White to off-white |
LogP | -0.760 (est) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
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Signal word | Danger | |||||||||
Hazard statements | H300 | |||||||||
Precautionary statements | P301+P330+P331+P310 | |||||||||
NFPA 704 |
|
ailanthone price More Price(22)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML2143 | Ailanthone ≥98% (HPLC) | 981-15-7 | 5MG | $143 | 2023-06-20 | Buy |
Sigma-Aldrich | SML2143 | Ailanthone ≥98% (HPLC) | 981-15-7 | 25MG | $567 | 2023-06-20 | Buy |
Cayman Chemical | 29194 | Ailanthone | 981-15-7 | 5mg | $116 | 2024-03-01 | Buy |
Cayman Chemical | 29194 | Ailanthone | 981-15-7 | 25mg | $485 | 2024-03-01 | Buy |
Cayman Chemical | 29194 | Ailanthone | 981-15-7 | 1mg | $37 | 2024-03-01 | Buy |
ailanthone Chemical Properties,Uses,Production
Description
Ailanthone is a quassinoid that has been found in Ailanthus and has diverse biological activities. It is active against the P. falciparum strains HB-3 and Dd-2 in vitro (IC50s = 0.003 and 0.037 μg/ml, respectively). Ailanthone is phytotoxic, inhibiting radish seed germination by 88% when used at a concentration of 1 mM. It inhibits dihydrotestosterone-induced androgen receptor transcriptional activity (IC50 = 69 nM in a reporter assay), as well as the growth and colony formation of LNCaP and 22RV1 androgen receptor-expressing cells, but not androgen receptor-negative PC3 and DU145 cells, when used at a concentration of 0.1 μM. Ailanthone (2 mg/kg) reduces tumor volume in 22Rv1, LNCaP, and VCaP castration-resistant prostate cancer (CRPC) mouse xenograft models.
Uses
Ailanthone has potent antineoplastic activity against anti-hepatocellular carcinoma (HCC) and has been shown to inhibit Huh7 cancer cell growth through cell cycle arrest and apoptosis in vitro and in vivo.
Definition
ChEBI: Ailanthone is a triterpenoid.
ailanthone Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29821 | 58 |
Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34571 | 58 |
Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
View Lastest Price from ailanthone manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2020-01-13 | ailanthone
981-15-7
|
US $9.80 / KG | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
- ailanthone
981-15-7
- US $9.80 / KG
- ≥98%
- Career Henan Chemical Co