2-(chloromethyl)-4-methylquinazoline
- CAS No.
- 109113-72-6
- Chemical Name:
- 2-(chloromethyl)-4-methylquinazoline
- Synonyms
- Quinazoline,2-(chloroMethyl)-4-Methyl-;Linaint-I;Linagliptin INT3;Linagliptin Impurity 67;Linagliptin interMediate A;CHLOROMETHYL)-4-METHYLQUINAZOLINE;2-chloroMethyl-4-Methyl quinaoline;2-(chloromethyl)-4-methylquizoline;Linagliptin 2-Chloromethyl Impurity;2-(chloromethyl)-4-methylquinazolin
- CBNumber:
- CB71648970
- Molecular Formula:
- C10H9ClN2
- Molecular Weight:
- 192.64
- MDL Number:
- MFCD09807547
- MOL File:
- 109113-72-6.mol
Melting point | 61.0 to 65.0 °C |
---|---|
Boiling point | 240.0±32.0 °C(Predicted) |
Density | 1.251 |
vapor pressure | 0Pa at 20℃ |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | powder to crystal |
pka | 1.86±0.50(Predicted) |
color | Light yellow to Yellow to Orange |
Water Solubility | 3.11g/L at 20℃ |
λmax | 318nm(EtOH)(lit.) |
InChIKey | UHCUBOJGMLASBY-UHFFFAOYSA-N |
LogP | 1.9 at 25℃ |
FDA UNII | KC7BTH55VT |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS05 |
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Signal word | Danger | |||||||||
Hazard statements | H314 | |||||||||
Precautionary statements | P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P405-P501 | |||||||||
RIDADR | 3261 | |||||||||
HazardClass | 8 | |||||||||
PackingGroup | III | |||||||||
HS Code | 2933998090 | |||||||||
NFPA 704 |
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2-(chloromethyl)-4-methylquinazoline price More Price(34)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | C2928 | 2-(Chloromethyl)-4-methylquinazoline >98.0%(GC) | 109113-72-6 | 1g | $78 | 2024-03-01 | Buy |
TCI Chemical | C2928 | 2-(Chloromethyl)-4-methylquinazoline >98.0%(GC) | 109113-72-6 | 200mg | $28 | 2024-03-01 | Buy |
TRC | C369850 | 2-(Chloromethyl)-4-methylquinazoline | 109113-72-6 | 2.5g | $95 | 2021-12-16 | Buy |
TRC | C369850 | 2-(Chloromethyl)-4-methylquinazoline | 109113-72-6 | 5g | $155 | 2021-12-16 | Buy |
TRC | C369850 | 2-(Chloromethyl)-4-methylquinazoline | 109113-72-6 | 25g | $400 | 2021-12-16 | Buy |
2-(chloromethyl)-4-methylquinazoline Chemical Properties,Uses,Production
Chemical Properties
White to yellow powder
Uses
2-(Chloromethyl)-4-methylquinazoline, is a building block used for the preparation of Linagliptin (L465900), and its impurities, acting as type 2 diabetes drugs.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 23, p. 1263, 1986 DOI: 10.1002/jhet.5570230458
Flammability and Explosibility
Not classified
Synthesis
Into a 500ml reaction flask, add o-aminoacetophenone, chloroacetonitrile, 1,4-dioxane, and N-methyl-3(3-sulfopropyl)imidazolium hydrogen sulfate prepared above. Stir to dissolve, cool the reaction system to 8°C, and dropwise add hydrochloric acid to the reaction system. The reaction temperature was kept unchanged during the dropwise addition. After that, the reaction was continued at 8°C for 18 hours to complete the reaction process. After the reaction, ammonia water (the concentration of ammonia water was 10wt%) at 5°C was added to the reaction system. After stirring and crystallizing at 5 for 30 minutes, filter to obtain a filter cake, washing the filter cake with water. Recrystallized with 200ml of dichloromethane to obtain 2-(chloromethyl)-4-methylquinazoline. yield: 85.14%
2-(chloromethyl)-4-methylquinazoline Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Joiny Pharmaceutical Co.,LTD | +8613681955282 | gyd@joiny-pharma.com | China | 253 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5882 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9317 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
View Lastest Price from 2-(chloromethyl)-4-methylquinazoline manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-20 | 2-(chloromethyl)-4-methylquinazoline
109113-72-6
|
US $1.00 / kg | 1kg | 99% | 1 ton | Nanjing Fred Technology Co., Ltd | ||
2024-09-20 | Linagliptin Impurity 67 | US $0.00-0.00 / mg | 10mg | 0.98 | 10g | ShenZhen H&D Pharmaceutical Technology Co., LTD | ||
2024-09-19 | 2-(Chloromethyl)-4-methylquinazoline
109113-72-6
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
- 2-(chloromethyl)-4-methylquinazoline
109113-72-6
- US $1.00 / kg
- 99%
- Nanjing Fred Technology Co., Ltd
- Linagliptin Impurity 67
- US $0.00-0.00 / mg
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
- 2-(Chloromethyl)-4-methylquinazoline
109113-72-6
- US $5.00-2.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD