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ETHYL OLEATE

Overview Uses
ETHYL OLEATE
ETHYL OLEATE structure
CAS No.
111-62-6
Chemical Name:
ETHYL OLEATE
Synonyms
oleic;(9Z)-;FEMA 2450;Ethyloleat;ETHYL OLEATE;Elhyl oleate;ethylis oleas;ETHYLOLEATE,NF;EthylOleate>ETHYL OLEATE, BP
CBNumber:
CB7301038
Molecular Formula:
C20H38O2
Formula Weight:
310.51
MOL File:
111-62-6.mol

ETHYL OLEATE Properties

Melting point:
−32 °C(lit.)
Boiling point:
216-218 °C15 mm Hg
Density 
0.87 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.451(lit.)
FEMA 
2450 | ETHYL OLEATE
Flash point:
>230 °F
storage temp. 
-20°C
solubility 
chloroform: soluble10%
form 
Oily Liquid
color 
Clear
Sensitive 
Light Sensitive
Merck 
14,6828
JECFA Number
345
BRN 
1727318
InChIKey
LVGKNOAMLMIIKO-VAWYXSNFSA-N
Substances Added to Food (formerly EAFUS)
ETHYL OLEATE
FDA 21 CFR
172.515
CAS DataBase Reference
111-62-6(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
Z2Z439864Y
NIST Chemistry Reference
9-Octadecenoic acid (Z)-, ethyl ester(111-62-6)
EPA Substance Registry System
Ethyl oleate (111-62-6)
SAFETY
  • Risk and Safety Statements
Safety Statements  23-24/25-22
WGK Germany  2
RTECS  RG3715000
10-23
TSCA  Yes
HS Code  29161900

ETHYL OLEATE price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 268011 Ethyl oleate 98% 111-62-6 5g $47.4 2021-03-22 Buy
Sigma-Aldrich W245000 Ethyl oleate natural, ≥85% 111-62-6 100 g $73.7 2021-03-22 Buy
Sigma-Aldrich W245000 Ethyl oleate natural, ≥85% 111-62-6 500 g $245 2021-03-22 Buy
Sigma-Aldrich 1266609 Ethyl oleate United States Pharmacopeia (USP) Reference Standard 111-62-6 1ml $399 2021-03-22 Buy
Sigma-Aldrich W245000 Ethyl oleate natural, ≥85% 111-62-6 1 kg $400 2021-03-22 Buy

ETHYL OLEATE Chemical Properties,Uses,Production

Overview

Ethyl oleate is a colourless liquid that is normally formed by condensing ethanol and oleic acid. Notably, the compound is normally produced by the body during intoxication of ethanol. Its other names are 9-Octadecenoic acid (Z)-, Ethyl cis-9-octadecenoate, (Z)-9-Octadecenoic acid ethyl ester, and Oleic acid, ethyl ester. The compound contributed to approximately 17% of the total fatty acids esterified to phosphatidylcholine in porcine platelets. Ethyl oleate is neutral and is a more lipid-soluble form of oleic acid.
The compound is one of the fatty acid ethyl esters that is generated after the breakdown of ethanol in the body. Moreover, ethyl oleate usually acts as a toxic mediator of ethanol in the heart, liver, pancreas, and brain.

Uses

Pharmaceutical Industry
Ethyl oleate is utilized as an ingredient for the preparations of pharmaceutical drugs that involves lipophilic substances such as steroids. Due to its quick degradation of the digestive system, ethyl oleate is employed as a way for intramuscular drug delivery by compounding pharmacies. In some cases, the compound is used in the preparation of day-to-day doses of progesterone in the sustenance of pregnancy.
Transport Industry
It is used in the transport industry as a lubricant and as a plasticiser. It is also used as a planting agent and for treating surfaces.
Food Industry
Ethyl oleate is used as a food additive and is regulated by the Food and Drug Administration. It is also used as a flavouring agent in food.

Description

Ethyl oleate is a fatty acid ester formed by the condensation of oleic acid and ethanol. It is a colorless to light yellow liquid. Ethyl oleate is produced by the body during ethanol intoxication.
Ethyl oleate is used as a solvent for pharmaceutical drug preparations involving lipophilic substances such as steroids. It also finds use as a lubricant and a plasticizer.
Ethyl oleate is regulated as a food additive by the Food and Drug Administration under "Food Additives Permitted for Direct Addition to Food for Human Consumption", 21CFR172.515.
Ethyl oleate has been identified as a primer pheromone in honeybees.
Ethyl oleate is one of the fatty acid ethyl esters (FAEE) that is formed in the body after ingestion of ethanol. There is a growing body of research literature that implicates FAEEs such as ethyl oleate as the toxic mediators of ethanol in the body (pancreas, liver, heart, and brain). Among the speculations is that ethyl oleate may be the toxic mediator of alcohol in fetal alcohol syndrome. The oral ingestion of ethyl oleate has been carefully studied and due to rapid degradation in the digestive tract it appears safe for oral ingestion. Ethyl oleate is not currently approved by the U.S. Food and Drug Administration for any injectable use. However, it is used by compounding pharmacies as a vehicle for intramuscular drug delivery, in some cases to prepare the daily doses of progesterone in support of pregnancy. Studies which document the safe use of ethyl oleate in pregnancy for both the mother and the fetus have never been performed.

Chemical Properties

Ethyl oleate has a faint, floral note.

Chemical Properties

clear pale yellow oily liquid

Chemical Properties

Ethyl oleate occurs as a pale yellow to almost colorless, mobile, oily liquid with a taste resembling that of olive oil and a slight, but not rancid odor.
Ethyl oleate is described in the USP32–NF27 as consisting of esters of ethyl alcohol and high molecular weight fatty acids, principally oleic acid. A suitable antioxidant may be included.

Occurrence

Reported found in cocoa, buckwheat, elderberry and babaco fruit (Carica pentagona Heilborn).

Uses

Ethyl oleate is a flavoring and fragrance agent.

Uses

It was obtained by the hydrolysis of various animal and vegetable fats and oils.

Uses

Usually used to prepare the oily phase of self-microemulsifying drug delivery system (SMEDDS) for tacrolimus (Tac).

Production Methods

Ethyl oleate is prepared by the reaction of ethanol with oleoyl chloride in the presence of a suitable hydrogen chloride acceptor.

Definition

ChEBI: A long-chain fatty acid ethyl ester resulting from the formal condensation of the carboxy group of oleic acid with the hydroxy group of ethanol.

Preparation

By direct esterification of oleic acid with ethyl alcohol in the presence of HCl at the boil; in the presence of Twitchell’s reagent or chlorosulfonic acid.

Aroma threshold values

Detection: 130 to 610 ppm

Pharmaceutical Applications

Ethyl oleate is primarily used as a vehicle in certain parenteral preparations intended for intramuscular administration. It has also been used as a solvent for drugs formulated as biodegradable capsules for subdermal implantation) and in the preparation of microemulsions containing cyclosporinand norcantharidin.
Microemulsion formulations containing ethyl oleate have also been proposed for topical and ocular delivery, and for liver targeting following parenteral administration. Ethyl oleate has been used in topical gel formulations, and in self-microemulsifying drug delivery systems for oral administration.
Ethyl oleate is a suitable solvent for steroids and other lipophilic drugs. Its properties are similar to those of almond oil and peanut oil. However, it has the advantage that it is less viscous than fixed oils and is more rapidly absorbed by body tissues.
Ethyl oleate has also been evaluated as a vehicle for subcutaneous injection.

Safety

Ethyl oleate is generally considered to be of low toxicity but ingestion should be avoided. Ethyl oleate has been found to cause minimal tissue irritation. No reports of intramuscular irritation during use have been recorded.

Carcinogenicity

Not listed by ACGIH, California Proposition 65, IARC, NTP, or OSHA.

storage

Ethyl oleate should be stored in a cool, dry place in a small, wellfilled, well-closed container, protected from light. When a partially filled container is used, the air should be replaced by nitrogen or another inert gas. Ethyl oleate oxidizes on exposure to air, resulting in an increase in the peroxide value. It remains clear at 5°C, but darkens in color on standing. Antioxidants are frequently used to extend the shelf life of ethyl oleate. Protection from oxidation for over 2 years has been achieved by storage in amber glass bottles with the addition of combinations of propyl gallate, butylated hydroxyanisole, butylated hydroxytoluene, and citric or ascorbic acid. A concentration of 0.03% w/v of a mixture of propyl gallate (37.5%), butylated hydroxytoluene (37.5%), and butylated hydroxyanisole (25%) was found to be the best antioxidant for ethyl oleate.
Ethyl oleate may be sterilized by heating at 150°C for 1 hour.

Incompatibilities

Ethyl oleate dissolves certain types of rubber and causes others to swell. It may also react with oxidizing agents.

Regulatory Status

Included in the FDA Inactive Ingredients Database (transdermal preparation). Included in parenteral (intramuscular injection) and nonparenteral (transdermal patches) medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

ETHYL OLEATE Preparation Products And Raw materials

Raw materials

Preparation Products


ETHYL OLEATE Suppliers

Global( 391)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
JIANGXI ALPHA HI-TECH PHARMACEUTICAL CO., LTD
86-51085010237
overseamarketing@alphahi-tech.com CHINA 42 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
18007166089 86-18007166089
circlepowder01@gmail.com CHINA 230 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20918 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1009 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58

View Lastest Price from ETHYL OLEATE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-25 ETHYL OLEATE
111-62-6
US $1.00 / g 1000g 99% 20ton/month Wuhan Aoliqisi New Material Technology Co., Ltd.
2021-11-15 ETHYL OLEATE
111-62-6
US $25.00 / KG 1KG 99% 200000pcs Hebei Yirun Sega Biological Technology Co. Ltd
2021-11-08 ETHYL OLEATE
111-62-6
US $5.00 / KG 1KG 99% 100 Tons Wuhan wingroup Pharmaceutical Co., Ltd

ETHYL OLEATE Spectrum


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