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Role and purpose Chemical Properties Uses Production methods
Chemical Name:
PTSA;PASAM;Tosylamide;Tosylamine;Uniplex 173;p-Tosylamide;p-Toluenesulfo;Tolylsulfonamide;p-Toluolsulfonamid;4-Tolylsulfonamide
Molecular Formula:
Formula Weight:
MOL File:

p-Toluenesulfonamide Properties

Melting point:
134-137 °C(lit.)
Boiling point:
221 °C (10 mmHg)
1.2495 (rough estimate)
refractive index 
1.6100 (estimate)
Flash point:
202 °C
storage temp. 
Store below +30°C.
DMSO: soluble
Crystalline Powder
Water Solubility 
0.32 g/100 mL (25 º C)
CAS DataBase Reference
70-55-3(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
Benzenesulfonamide, 4-methyl-(70-55-3)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,Xn
Risk Statements  36-20/21/22
Safety Statements  26-36
WGK Germany  1
RTECS  XT5075000
PackingGroup  III
HS Code  29350090
Hazardous Substances Data 70-55-3(Hazardous Substances Data)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

p-Toluenesulfonamide price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 105902 p-Toluenesulfonamide reagent grade, 98% 70-55-3 250g $24.6 2017-11-08 Buy
Sigma-Aldrich 105902 p-Toluenesulfonamide reagent grade, 98% 70-55-3 1kg $64.9 2017-11-08 Buy
TCI Chemical T0281 p-Toluenesulfonamide >98.0%(HPLC)(N) 70-55-3 25g $14 2017-11-08 Buy
TCI Chemical T0281 p-Toluenesulfonamide >98.0%(HPLC)(N) 70-55-3 500g $28 2017-11-08 Buy
Alfa Aesar A12156 p-Toluenesulfonamide, 98+% 70-55-3 500g $47.3 2017-11-08 Buy

p-Toluenesulfonamide Chemical Properties,Uses,Production

Role and purpose

P-toluene sulfonamide is a kind of excellent solid plasticizer used for thermoset plastic. It is suitable for being applied to phenolic resin, melamine resin, urea-formaldehyde resins and polyamide resins. Combination with a small amount can improve workability and make the solidification be uniform, and thus endowing the products with a good gloss. However, P-toluene sulfonamide has no softening effect as the liquid plasticizer, and is incompatible with polyvinyl chloride and vinyl chloride copolymer and is partially compatible with cellulose acetate, cellulose acetate butyrate and cellulose nitrate.
p-Toluene sulfonamide has a low toxicity. It has been approved by the US Food and Drug Administration for being applied into adhesives as food packaging materials.
p-Toluene sulfonamide is briefly called TSH and is commonly used for nickel plating. It can improve the coating structure by the adsorption on the electrode so that it has some degree of surface glossing effect; it is generally not strictly limited for the added amount of brighteners lax; moreover it also has very light effects on the coating characteristics. However, it can only give semi-bright coatings, and the surface gloss is related to the polishing quality of the matrix before plating.
Currently, the brightener agents of nickel plating used is mostly some kinds of organic compounds. And the used amount of these organic compound, although are very little, but with a significant effect. In addition to brightening the coating, it can also largely determine the mechanical properties and chemical properties of the coating. But it must be realized that, since the bright nickel plating solution has been added to the organic brightener, it naturally makes the nickel plating layer contain a relative big amount of organic sulfur and other impurities, thus inevitably enlarging the internal stress, so its mechanical properties is a bitter lower than the conventional nickel-plate, and is prone to crack layer when the plating gets stress; its antirust ability is also worse than the dark nickel. Thus, a single layer of bright nickel is unable to improve the corrosion resistance and mechanical properties of the nickel layer; it must need to form a bi-layer and multilayer nickel or chromium to form a multilayer combination of decorative protective coatings.
When toluene sulfonamide is heated to 105 °C, it will be decomposed and there will be nitrogen released (gas evolution 130 mL/g); p-toluene sulfonamide foaming agents can give a fine foaming with small product shrinkage. It also has a high tear strength and good stability. Thereby, it has a wide range of applications.
The above information is edited by the chemicalbook of Dai xiongfeng.

Chemical Properties

It is white flaky crystal. It is soluble in ethanol but insoluble in water and ether.


1. It is used in the manufacture of dyes, synthetic resins, paints, disinfectants and wood processing brightener.
2. It is used for the manufacture of plasticizers, disinfectants; it can also be used for the production of synthetic resins, paints, and fluorescent dyes.
3. It can be used as primary brightener in the bright nickel plating. It is sued for bright nickel plating for multilayer to obtain uniform bright coating. It has a commonly used amount of 0.2~0.3 g/L.
4. It can be used as plasticizers, also used for synthesis of organics, resins and saccharin.

Production methods

It is obtained by the reaction between toluenesulfonyl chloride and ammonia.
First, add part of HN3 water into the reaction pot, stirring for adding p-toluenesulfonyl chloride with the temperature rising naturally to above 50 °C; after the temperature has dropped, add the remaining ammonia and have reaction for 0.5 h at 85~90 °C. Stop the reaction when the pH reaches 8 to 9. Cool to 20 °C, filter, and wash the filter cake with water to obtain the crude. Then further go through bleaching via activated carbon, alkali dissolution, acid precipitation, rejection filter, drying to get products.

Chemical Properties

white crystalline powder


4-Tolylsulfonamide is a carbonic anhydrase inhibitor used the synthesis of antiglaucoma and anticancer drugs.


Used in the manufacture of plasticizer, disinfectant, fungicide, fungicides, wood brightener. Also can be used in the production of synthetic resin, the coating, the fluorescent dye, pharmaceutical, etc.


ChEBI: A sulfonamide that is benzenesulfonamide bearing a methyl group at position 4.

Purification Methods

Crystallise the amide from hot water, then from EtOH or Et2O/pet ether. [Beilstein 11 H 104, 11 IV 376.]

p-Toluenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

p-Toluenesulfonamide Suppliers

Global( 266)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3218 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22144 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20803 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32765 55
020-81716319 CHINA 2549 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1428 55
career henan chemical co
+86-371-86658258 CHINA 10012 58
Jiaxing Trustworthy Import And Export Co., Ltd. +86 (573) 8203-0555 China 38 56
Credit-Chem Co., Ltd. 400-821-5857 021-64326257
021-64393586 QQ;2798200800 China 5273 58
Heze Kingvolt Chemical Co., Ltd +86-15157335533 13505737768
+86-0573-82118912 China 23 55

View Lastest Price from p-Toluenesulfonamide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 p-Toluenesulfonamide
US $1.00 / KG 1KG 98% 100KG

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