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6-Mercaptopurine monohydrate

6-Mercaptopurine monohydrate
6-Mercaptopurine monohydrate structure
CAS No.
6112-76-1
Chemical Name:
6-Mercaptopurine monohydrate
Synonyms
USP, EP;6MP H2O;DMF available;MERCAPTOPURINE;6MP MONOHYDRATE;6-Mercaptopurine mon;6-Mercaptopurine API;LEUKERIN MONOHYDRATE;6-Mercaptopurine mercaptopurine hydrate
CBNumber:
CB7337963
Molecular Formula:
C5H6N4OS
Formula Weight:
170.19
MOL File:
6112-76-1.mol

6-Mercaptopurine monohydrate Properties

Melting point:
>300 °C(lit.)
storage temp. 
Store at 0-5
solubility 
INSOLUBLE
form 
Fine Powder
color 
Yellow
Water Solubility 
INSOLUBLE
Merck 
14,5871
BRN 
4012091
Stability:
Stable. Incompatible with strong oxidizing agents, acids, strong bases. Light sensitive.
CAS DataBase Reference
6112-76-1(CAS DataBase Reference)
EPA Substance Registry System
6H-Purine-6-thione, 1,7-dihydro-, monohydrate(6112-76-1)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38-63-20/21/22
Safety Statements  22-36/37/39-45-36/37
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
RTECS  UP0400000
HS Code  29335995
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

6-Mercaptopurine monohydrate price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 852678 6-Mercaptopurine monohydrate 98% 6112-76-1 1g-a $42.5 2018-11-13 Buy
Sigma-Aldrich 1392002 Mercaptopurine United States Pharmacopeia (USP) Reference Standard 6112-76-1 500mg $348 2018-11-13 Buy
TCI Chemical M0063 6-Mercaptopurine Monohydrate >98.0%(HPLC)(T) 6112-76-1 1g $20 2018-11-22 Buy
TCI Chemical M0063 6-Mercaptopurine Monohydrate >98.0%(HPLC)(T) 6112-76-1 5g $60 2018-11-22 Buy
Alfa Aesar A12197 6-Mercaptopurine monohydrate, 98% 6112-76-1 5g $63.3 2018-11-13 Buy

6-Mercaptopurine monohydrate Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powder

Uses

An immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin lymphoma, polycythemia vera, and psoriatic arthritis

Uses

An immunosuppressive drug used to treat leukemia. It is also used for pediatric non-Hodgkin’s lymphoma, polycythemia vera, and psoriatic arthritis.

Uses

antihypertensive, ACE inhibitor

Indications

Mercaptopurine (Purinethol) is an analogue of hypoxanthine and was one of the first agents shown to be active against acute leukemias. It is now used as part of maintenance therapy in acute lymphoblastic leukemia. Mercaptopurine must be activated to a nucleotide by the enzyme HGPRTase. This metabolite is capable of inhibiting the synthesis of the normal purines adenine and guanine at the initial aminotransferase step and inhibiting the conversion of inosinic acid to the nucleotides adenylate and guanylate at several steps. Some mercaptopurine is also incorporated into DNA in the form of thioguanine. The relative significance of these mechanisms to the antitumor action of mercaptopurine is not clear.
Resistance to mercaptopurine may be a result of decreased drug activation by HGPRTase or increased inactivation by alkaline phosphatase.
The plasma half-life of an intravenous bolus injection of mercaptopurine is 21 minutes in children and 47 minutes in adults. After oral administration, peak plasma levels are attained within 2 hours. The drug is 20% bound to plasma proteins and does not enter the CSF. Xanthine oxidase is the primary enzyme involved in the metabolic inactivation of mercaptopurine.
Mercaptopurine is used in the maintenance therapy of acute lymphoblastic leukemia. It also displays activity against acute and chronic myelogenous leukemias.
The major toxicities of mercaptopurine are myelosuppression, nausea, vomiting, and hepatic toxicity.

brand name

Purinethol (Teva).

General Description

The drug is available as a 50-mg tablet for oral use. The primaryuses of mercaptopurine are in the treatment of lymphoblasticleukemia, acute lymphocytic leukemia, and Crohndisease. The mechanism of action includes incorporation ofmercaptopurine into DNA and RNA via the triphosphatemetabolite. This incorporation inhibits synthesis and functionof the resulting modified DNA or RNA. The parent drug isinactive and requires phosphorylation for activity. Resistancecan occur via decreased expression of the activating enzymesor increased expression of the major catabolic enzymes.Oral absorption is generally incomplete (about 50%) andthe drug does not enter the CNS in therapeutic quantities.Mercaptopurine is metabolized by methylation, and themethylated product has anticancer activity. Oxidation byxanthine oxidase yields inactive metabolites. The concurrentuse of xanthine oxidase inhibitors such as allopurinol can enhancethe potency of mercaptopurine by inhibiting its catabolicbreakdown. The toxicities for mercaptopurine includemyelosuppression, immunosuppression, nausea, vomiting,diarrhea, dry skin, urticaria, and photosensitivity.

General Description

Odorless light yellow to yellow crystalline powder. Becomes anhydrous at 284°F.

Air & Water Reactions

6-Mercaptopurine monohydrate is sensitive to light and oxidation. Insoluble in water.

Reactivity Profile

6-Mercaptopurine monohydrate reacts with strong oxidizing agents, strong bases and strong acids.

Fire Hazard

Flash point data for 6-Mercaptopurine monohydrate are not available. 6-Mercaptopurine monohydrate is probably combustible.

Purification Methods

Crystallise 6-mercaptopurine from pyridine (30mL/g), wash it with pyridine, then triturate with water (25mL/g) and adjust to pH 5 by adding M HCl. Recrystallise it by heating, then cooling, the solution. Filter off the solid, wash it with water and dry it at 110o. It has also been crystallised from water (charcoal) as yellow crystals of the monohydrate which become anhydrous on drying at 140o. It has UV: at 230 and 312nm ( 14,000 and 19,600) in 0.1N NaOH; 222 and 327nm ( 9,2400 max and 21,300), and 216 and 329nm ( 8,740 and 19,300) in MeOH. It forms a 1:1 complex with Zn2+ , Pb2+ , Co2+, and Ni2+ in aqueous dioxan. It is an antineoplastic. [Albert & Brown J Chem Soc 2060 1954, IR: Brown & Mason J Chem Soc 682 1957, UV: Fox et al. J Am Chem Soc 80 1669 1958, UV: Mason J Chem Soc 2071 1954, Beilstein 26 III/IV 2097.]

6-Mercaptopurine monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products


6-Mercaptopurine monohydrate Suppliers

Global( 197)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19919 60
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23982 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20094 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40277 62
INTATRADE GmbH +49 3493/605464
+49 3493/605470 sales@intatrade.de Germany 3580 66
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 saleschina@alfa-asia.com China 30168 84

View Lastest Price from 6-Mercaptopurine monohydrate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-01 6-Mercaptopurine monohydrate
6112-76-1
US $100.00 / KG 1KG 99% Customized career henan chemical co

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