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ChemicalBook >> CAS DataBase List >>6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE

6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE

6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Structure
6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE structure
CAS No.
63744-22-9
Chemical Name:
6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE
Synonyms
8-dibroMoiMidazo[1;6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE;6,8-Dibromoimidazol[1,2-a]pyrazine;6,8-Dibromoimidazo[1,2-a]pyrazine>IMidazo[1,2-a]pyrazine, 6,8-dibroMo-;6,8-Dibromoimidazo[1,2-a]pyrazine,95%;6,8-Dibromo imidazole [1,2-A] pyrazine
CBNumber:
CB7726277
Molecular Formula:
C6H3Br2N3
Molecular Weight:
276.92
MDL Number:
MFCD08460056
MOL File:
63744-22-9.mol
Last updated:2025-08-30 07:39:51
Product description Number Pack Size Price
6,8-Dibromoimidazo[1,2-a]pyrazine >98.0%(GC) D4967 1g $54
6,8-Dibromoimidazo[1,2-a]pyrazine >98.0%(GC) D4967 5g $192
6,8-Dibromoimidazo[1,2-a]pyrazine D425495 10g $1230
6,8-Dibromoimidazo[1,2-a]pyrazine >95% 069985 5g $2999
6,8-Dibromoimidazo[1,2-a]pyrazine FD140693 2g $60
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6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Properties

Melting point 165.0 to 169.0 °C
Density 2.35±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form powder to crystal
pka -0.36±0.30(Predicted)
color White to Amber
Water Solubility Slightly soluble in water.
InChI InChI=1S/C6H3Br2N3/c7-4-3-11-2-1-9-6(11)5(8)10-4/h1-3H
InChIKey UQCZZGIPIMJBCL-UHFFFAOYSA-N
SMILES C12=NC=CN1C=C(Br)N=C2Br

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
HS Code  2933998090
NFPA 704
1
2 0

6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D4967 6,8-Dibromoimidazo[1,2-a]pyrazine >98.0%(GC) 63744-22-9 1g $54 2025-07-31 Buy
TCI Chemical D4967 6,8-Dibromoimidazo[1,2-a]pyrazine >98.0%(GC) 63744-22-9 5g $192 2025-07-31 Buy
TRC D425495 6,8-Dibromoimidazo[1,2-a]pyrazine 63744-22-9 10g $1230 2021-12-16 Buy
Matrix Scientific 069985 6,8-Dibromoimidazo[1,2-a]pyrazine >95% 63744-22-9 5g $2999 2021-12-16 Buy
Biosynth Carbosynth FD140693 6,8-Dibromoimidazo[1,2-a]pyrazine 63744-22-9 2g $60 2021-12-16 Buy
Product number Packaging Price Buy
D4967 1g $54 Buy
D4967 5g $192 Buy
D425495 10g $1230 Buy
069985 5g $2999 Buy
FD140693 2g $60 Buy

6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Chemical Properties,Uses,Production

Uses

It is an Intermediate in organic syntheses.

Uses

6,8-Dibromoimidazo[1,2-a]pyrazine is a imidazopyrazine derivative with uterine-relaxing, antibronchospastic, and cardiac-stimulating properties. 6,8-Dibromoimidazo[1,2-a]pyrazine also displays theophylline-like properties.

Synthesis

Bromoacetaldehyde dimethyl acetal

7252-83-7

2-Amino-3,5-dibromopyrazine

24241-18-7

6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE

63744-22-9

1. 3,5-dibromopyrazin-2-amine (1018 g, 4.03 mol) was dissolved in water (10 kg) at room temperature. 2. 2-bromo-1,1-dimethoxyethane (1.79 kg, 4.14 mol) was added to the above solution and mixed with stirring. 3. The reaction mixture was heated to reflux and held for 2 hours. 4. After the reaction was complete, water (15.3 kg) and sodium bicarbonate (744 g) were added to the reaction solution and stirring was continued for 15 minutes. 5. The reaction mixture was filtered and the solid product was collected. 6. 6. After drying, 6,8-dibromoimidazo[1,2-A]pyrazine (1106 g, 3.99 mmol, 99% yield) was obtained as a brown solid. 7. The structure of the product was confirmed by 1H-NMR (400 MHz, DMSO-d6): δ 7.90 (s, 1H), 8.23 (s, 1H), 9.02 (s, 1H).

References

[1] Patent: US2012/59162, 2012, A1. Location in patent: Page/Page column 53-54
[2] Patent: WO2005/85252, 2005, A1. Location in patent: Page/Page column 37-38; 40-41
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 1, p. 512 - 516
[4] Patent: WO2016/209895, 2016, A1. Location in patent: Paragraph 15; 16

6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE synthesis

24241-18-7
2032-35-1
63744-22-9
Synthesis of 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE from 2-Amino-3,5-dibromopyrazine and Bromoacetaldehyde diethyl acetal

6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Preparation Products And Raw materials

Raw materials

Bromoacetaldehyde Chloroacetaldehyde Bromoacetaldehyde dimethyl acetal Sodium bicarbonate 2-Amino-3,5-dibromopyrazine
Bromoacetaldehyde diethyl acetal

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Preparation Products

6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Suppliers

Global( 253)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29850 58
Shanghai Arbor Chemical Co., Ltd. 		021-60451682 act@arborchemical.com CHINA 904 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5743 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Shanghai Arbor Chemical Co., Ltd. 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58

View Lastest Price from 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE pictures 2025-09-23 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE
63744-22-9
 US $0.00-0.00 / KG 1KG 98% 2000 Shenzhen Nexcon Pharmatechs Ltd.
6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE pictures 2019-07-06 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE
63744-22-9
 US $8.00 / kg 1kg 99% 10tons Career Henan Chemical Co

6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE Spectrum

6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE(63744-22-9)1HNMR

63744-22-9(6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE)Related Search:

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8-dibroMoiMidazo[1 6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE 6,8-Dibromoimidazol[1,2-a]pyrazine IMidazo[1,2-a]pyrazine, 6,8-dibroMo- 6,8-Dibromoimidazo[1,2-a]pyrazine> 6,8-Dibromoimidazo[1,2-a]pyrazine,95% 6,8-Dibromo imidazole [1,2-A] pyrazine 63744-22-9 C6H3Br2N3 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals CHIRAL CHEMICALS Heterocycles series