glisoxepide
- CAS No.
- 25046-79-1
- Chemical Name:
- glisoxepide
- Synonyms
- FBB-4231;RP-22410;Pro-Diaban;BAY B-4231;Glisoxepid;glisoxepide;Glisoxepid (10mM in DMSO);N-[2-[4-(azepan-1-ylcarbamoylsulfamoyl)phenyl]ethyl]-5-methyl-1,2-oxazole-3-carboxamide;3-Isoxazolecarboxamide, N-[2-[4-[[[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl-;Pivaloyloxymethyl [2S-(2?,5?,6?)]-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate monohydrochloride
- CBNumber:
- CB7880449
- Molecular Formula:
- C20H27N5O5S
- Molecular Weight:
- 449.529
- MDL Number:
- MFCD00865498
- MOL File:
- 25046-79-1.mol
| Melting point | 189° |
|---|---|
| Density | 1.2348 (rough estimate) |
| refractive index | 1.6460 (estimate) |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly) |
| form | Solid |
| pka | 5.92±0.10(Predicted) |
| color | Pale Yellow to Yellow |
| FDA UNII | H7SC0I332I |
| NCI Drug Dictionary | glisoxepide |
| ATC code | A10BB11 |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in mice, rats, cats, dogs (g/kg): >10.0, >10.0, >4.0, >2.0 orally; in mice, rats (mg/kg): 283, 196 i.v. (Tettenborn) |
|---|
glisoxepide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | G410600 | Glisoxepid | 25046-79-1 | 100mg | $1355 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009129 | GLISOXEPIDE 95.00% | 25046-79-1 | 100MG | $1871.1 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009129 | GLISOXEPIDE 95.00% | 25046-79-1 | 10MG | $315 | 2021-12-16 | Buy |
glisoxepide Chemical Properties,Uses,Production
Originator
Pro-Diaban,Bayer,W. Germany,1974
Uses
Labelled Glisoxepid (G410600). Glisoxepid is used as an antidiabetic drug. Glisoxepid is a sulfonylurea derivative used in the treatment of diabetes mellitus type 2.
Definition
ChEBI: Glisoxepide is a sulfonamide.
Manufacturing Process
There is obtained from 4-[β-[5-methyl-isoxazolyl-(3)-carboxamido]-ethyl]-
benzene-sulfonamide (prepared from 5-methyl-isoxazole-(3)-carboxylic acid
chloride and 4-(β-aminoethyl)benzene-sulfonamide hydrochloride, MP 213° to
214°C in pyridine) and chloroformic acid methyl ester, in a yield of 69%, the
compound N-[[-4-[β-[5-methyl-isoxazolyl-(3)-carboxamido]-ethyl]]-benzenesulfonyl]]-methyl-urethane in the form of colorless crystals of MP 173°C.
From the sulfonyl-urethane described above and N-amino-hexamethyleneimine, there is obtained, in a yield of 70%. the compound 4-[[4-[β-[5-methylisoxazolyl-(3)-carboxamido]-ethyl]-benzene-sulfonyl]]-1,1-hexamethylenesemicarbazide in the form of colorless crystals of MP 189°C.
Therapeutic Function
Oral hypoglycemic
glisoxepide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223 | psaitong@jm-bio.com | China | 29834 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Shaanxi Dideu Newmaterial Co., Ltd. | 029-63373950 15353716720 | 1052@dideu.com | China | 10007 | 58 |