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Ivabradine hydrochloride

Ivabradine hydrochloride
Ivabradine hydrochloride structure
CAS No.
148849-67-6
Chemical Name:
Ivabradine hydrochloride
Synonyms
S-16257;Corlentor;S 16257-2;Procoralan;Ivabradine HCl;2H-3-Benzazepin-2-on;Ivabridine hydracloride;Ivabradine hydrochlorid;lvabradine hydrochloride;Ivabradine hydrochloride
CBNumber:
CB81006694
Molecular Formula:
C27H36N2O5.HCl
Formula Weight:
505.05
MOL File:
148849-67-6.mol

Ivabradine hydrochloride Properties

Melting point:
193-196?C
alpha 
58921 +7.8°; 36521 +27.8° (c = 1% in DMSO)
storage temp. 
-20°C Freezer
solubility 
H2O: ≥5mg/mL (warmed)
form 
powder
color 
white to beige
optical activity
[α]/D +5 to +9°, c = 1 in DMSO
Merck 
14,5247
InChIKey
HLUKNZUABFFNQS-ZMBIFBSDSA-N
CAS DataBase Reference
148849-67-6(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  N
Risk Statements  50/53
Safety Statements  60-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.

Ivabradine hydrochloride price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0281 Ivabradine hydrochloride ≥98% (HPLC) 148849-67-6 10mg $72.6 2018-11-13 Buy
Sigma-Aldrich SML0281 Ivabradine hydrochloride ≥98% (HPLC) 148849-67-6 50mg $295 2018-11-13 Buy
TCI Chemical I0847 Ivabradine Hydrochloride >98.0%(HPLC)(N) 148849-67-6 1g $618 2018-11-22 Buy
TCI Chemical I0847 Ivabradine Hydrochloride >98.0%(HPLC)(N) 148849-67-6 200mg $183 2018-11-22 Buy
Cayman Chemical 15868 Ivabradine (hydrochloride) ≥95% 148849-67-6 50mg $221 2018-11-13 Buy

Ivabradine hydrochloride Chemical Properties,Uses,Production

Description

In an effort to develop angina agents without the unwanted negative inotropic and hypotensive effects associated with b-adrenergic blockers and calcium channel blockers, a new class of heart-rate reducing compounds that act specifically on the sinoatrial (SA) node has been explored. These bradycardic agents interact directly with the pacemaking cell of the SA node and the hyperpolarization- activated If , the primary pacemaking current. Ivabradine has evolved as a specific inhibitor of If current through its contact with f-channels on the intracellular side of the plasma membrane. As a consequence, ivabradine reduces the speed of diastolic depolarization and decreases heart rate. It has been approved for the treatment of chronic stable angina and provides a viable alternative to patients with a contraindication or intolerance of b-blockers. Evaluation is also underway for the potential treatment of ischemic heart disease. Using a patch-clamp technique on rabbit sinoatrial node cells, inhibition of If current ranged from 6% (0.03 mM) – 80% (10 mM). .

Chemical Properties

White to Off-White Solid

Originator

Servier (France)

Uses

Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal

Uses

Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent

Uses

angina therapeutic

Definition

ChEBI: A hydrochloride obtained by combining ivabradine with one molar equivalent of hydrochloric acid. Used to treat patients with angina who have intolerance to beta blockers and/or heart failure.

brand name

Procoralan

Ivabradine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Ivabradine hydrochloride Suppliers

Global( 189)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1530 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
Jiangsu Qingquan Chemical Co., Ltd.
+86-571-86589381/86589382/86589383
lyy@qqpharm.com sales1@qqpharm.com CHINA 177 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 16534 60
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 617 58
Jinan Shengqi pharmaceutical Co,Ltd
86+15552594168
christine@shengqipharm.com CHINA 339 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24118 58

View Lastest Price from Ivabradine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-02 Ivabradine hydrochloride
148849-67-6
US $200.00 / KG 1KG 99% 10kg career henan chemical co
2018-12-24 Ivabradine hydrochloride
148849-67-6
US $950.00 / KG 0.01KG 99.6% 500kg/month Hebei Huanhao Biotechnology Co., Ltd.

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