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Aclidinium bromide

Aclidinium bromide
Aclidinium bromide structure
CAS No.
320345-99-1
Chemical Name:
Aclidinium bromide
Synonyms
LAS-W 330;LAS 34273;Unii-uqw7uf9N91;ACLIDINIUM BROMIDE;Adiguanium bromide;ACLIDINIUM BROMIDE INTERMEDIATES;(3R)-3-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-1-(3-phenoxypropyl)quinuclidin-1-ium bromide;(3R)-(2-Hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide;1-Azoniabicyclo(2.2.2)octane, 3-((hydroxydi-2-thienylacetyl)oxy)-1-(3-phenoxypropyl)-, bromide, (3R)-;1-Azoniabicyclo[2.2.2]octane, 3-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-1-(3-phenoxypropyl)-, bromide (1:1), (3R)-
CBNumber:
CB81092082
Molecular Formula:
C13H10BrN
Formula Weight:
564.56
MOL File:
320345-99-1.mol

Aclidinium bromide Properties

SAFETY

Aclidinium bromide price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 20699 Aclidinium (bromide) ≥95% 320345-99-1 5mg $25 2018-11-19 Buy
Cayman Chemical 20699 Aclidinium (bromide) ≥95% 320345-99-1 10mg $48 2018-11-19 Buy
Cayman Chemical 20699 Aclidinium (bromide) ≥95% 320345-99-1 25mg $113 2018-11-19 Buy
Cayman Chemical 20699 Aclidinium (bromide) ≥95% 320345-99-1 50mg $200 2018-11-19 Buy

Aclidinium bromide Chemical Properties,Uses,Production

Description

In July 2012, aclidinium bromide was approved in the US and the EU for long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disorder (COPD). Aclidinium bromide is in the latter category, acting as a selective antagonist for the muscarinic M3 receptor. M3 receptors are localized in airway smooth muscle, and are the primary subtype responsible for bronchial and tracheal smooth muscle contraction. Muscarinic antagonists are well-established bronchodilators that are effective for treating COPD, but these agents have unwanted side effects if systemically absorbed. Systemic exposure can be limited by inhaled administration, which is the route of delivery for aclidinium bromide. In addition, aclidinium bromide was designed to undergo rapid hydrolysis in human plasma, providing inactive acid and alcohol products, and reducing the potential for systemic side effects. Aclidinium bromide was identified amongst a series of quaternary ammonium (3R)-quinuclidinol esters as having the best combination of high potency (M3 Ki=0.14 nM), long duration of action (29 h for 50% reduction of therapeutic effect in a guinea pig bronchoconstriction model), low oral absorption, and rapid plasma degradation. The synthesis of aclidinium bromide was achieved by reaction of dimethyl oxalate with 2-thienylmagnesium bromide followed by treatment of the resulting methyl ester with (3R)-quinuclidinol in the presence of sodium hydride. Quaternization of the amine was achieved by treatment with 3-phenoxypropyl bromide to give aclidinium bromide.

Originator

Almirall (Spain)

Uses

Aclidinium Bromide inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with Ki of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively

Uses

Aclidinium Bromide is a novel long-acting antimuscarinic bronchodilator in phase II clinical trials for the treatment of chronic obstructive pulmonary disease.

Definition

ChEBI: A quaternary ammonium salt that is the bromide salt of aclidinium. A muscarinic acetylcholine M3 receptor antagonist, for the long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD).

brand name

Tudorza Pressair? (US) Eklira?/Bretaris? Genuair? (EU)

Aclidinium bromide Preparation Products And Raw materials

Raw materials

Preparation Products


Aclidinium bromide Suppliers

Global( 88)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21753 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24192 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 27142 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 955 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23964 58
Shandong ruiyue Biological Technology Co.,Ltd.
008615066100122(Lily wechat);008618953188003(Fiona wechat);008618805314509(wechat)
053188581623 513075341@qq.com;1021501167@qq.com;1456922171@qq.com CHINA 59 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58
Shanghai Changyan Chem & Tech Co., Ltd. +86 (21) 2024-2659
+86 (21) 2024-2659 order@changyanchem.com China 5001 55
Hubei Hongxin Ruiyu Fine Chemical Co., Ltd. 027-65385071,027-65021350,027-65528353,15307120296,17771822910,18062757896
027-65526669 2056564811@qq.com China 999 58

View Lastest Price from Aclidinium bromide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-22 Aclidinium bromide
320345-99-1
US $7.00 / kg 1kg 99% 100KG career henan chemical co
2019-05-11 Adiguanium bromide
320345-99-1
US $0.00-0.00 / KG 50g HPLC 99% 1kg per month Shandong ruiyue Biological Technology Co.,Ltd.

320345-99-1(Aclidinium bromide)Related Search:


  • 1-Azoniabicyclo(2.2.2)octane, 3-((hydroxydi-2-thienylacetyl)oxy)-1-(3-phenoxypropyl)-, bromide, (3R)-
  • Unii-uqw7uf9N91
  • LAS 34273
  • LAS-W 330
  • (3R)-3-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-1-(3-phenoxypropyl)quinuclidin-1-ium bromide
  • ACLIDINIUM BROMIDE INTERMEDIATES
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  • ACLIDINIUM BROMIDE
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  • 320345-99-1
  • C26H30BrNO4S2
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  • Inhibitors
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