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Tiotropium bromide

Tiotropium bromide
Tiotropium bromide structure
CAS No.
136310-93-5
Chemical Name:
Tiotropium bromide
Synonyms
Ba-679;Ba-679 BR;TiopropiuM;otropiuM broMide;TIOTROPIUM BROMIDE;Tiotropium bromide, >=99%;TiotropiuM broMide anhydrous;Anhydrous Tiotropium Bromide;TiotropiuM BroMide(Spiriva, BA 679BR);Tiotropium Bromide cas136310-93-5(whatsapp:+8618830163278)
CBNumber:
CB4244930
Molecular Formula:
C19H22BrNO4S2
Formula Weight:
472.42
MOL File:
136310-93-5.mol

Tiotropium bromide Properties

Melting point:
218-2200C
storage temp. 
Refrigerator
λmax
240nm(lit.)
Merck 
14,9454
CAS DataBase Reference
136310-93-5(CAS DataBase Reference)

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Tiotropium bromide price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical T3032 Tiotropium Bromide >98.0%(HPLC)(T) 136310-93-5 50mg $194 2018-11-22 Buy
TCI Chemical T3032 Tiotropium Bromide >98.0%(HPLC)(T) 136310-93-5 200mg $581 2018-11-22 Buy
Cayman Chemical 15773 Tiotropium (bromide) ≥98% 136310-93-5 1mg $59 2018-11-13 Buy
Cayman Chemical 15773 Tiotropium (bromide) ≥98% 136310-93-5 5mg $115 2018-11-13 Buy
Cayman Chemical 15773 Tiotropium (bromide) ≥98% 136310-93-5 25mg $354 2018-11-13 Buy

Tiotropium bromide Chemical Properties,Uses,Production

Description

Tiotropium bromide is a long-acting inhaled muscarinic antagonist, developed for the once-daily treatment of chronic obstructive pulmonary disease. Tiotropium bromide can be prepared in three steps. The Grignard condensation of 2-thienyl magnesium bromide with oxalic acid dimethyl ester, followed by a transesterlfication with scopine provided the ester which was quaternized with methyl bromide. Tiotropium bromide binds to human recombinant muscarinic receptors M1-, M2- and M3-subtypes with high and similar affinity, comparable to those obtained with ipratropium. Tiotropium bromide is characterized by its novel property of kinetic selectivity : while ipratropium rapidly dissociated from each of the receptor subtypes, tiotropium dissociated rapidly from M2 receptors (t1/2=3.6 h) but slowly from MI (t1/2=14.6 h) and M3 (t1/2=34.7 h) receptors. Inhibition of cholinergic bronchospasm by tiotropium bromide was demonstrated in anesthetized guinea pigs, rabbits and dogs. In healthy volunteers, inhalation of tiotropium bromide resulted in an absolute bioavailability of 19.5%, a t,,, value of 5 min. and the terminal half-life value of 5-6 days. There was no evidence of drug accumulation after repeated administration. The extent of biotransfonation was small with a urinary excretion of 74% of unchanged substance after iv. administration. Long term studies in patients with stable COPD have demonstrated that tiotropium bromide gave an effective bronchodilation that was maintained over 24h, significantly improved lung function as measured by FEVI (+ll-12%) and showed progressive reduction in dyspnea. It also reduced exacerbations of COPD patients and improved quality of life. Tiotropium bromide produced greater and more sustained bronchodilation than ipratropium bromide. Tiotropium has been shown to cause superior bronchodilatation and symptomatic improvements when compared to twice daily salmeterol in COPD. Tiotropium bromide was well tolerated and caused few adverse effects. The most common side effect reported was the mechanism-related effect of dry mouth.

Chemical Properties

White Solid

Originator

Boehringer lngelheim (Germany)

Uses

Muscarinic receptor antagonist. Bronchodilator

Uses

Specially selective choline drug resistance

Uses

Anti - Asthmatic

Definition

ChEBI: An organic bromide salt having (1alpha,2beta,4beta,5alpha,7beta)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]non ne as the counterion. Used (in the form of the hydrate) for maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease.

brand name

Spiriva

General Description

Tiotropium bromide, (1 ,2 ,4 ,7 )-7-[(hydroxidi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane, (Spiriva) is anantimuscarinic agent that is used in an inhalation device to deliverthe drug into the lungs. It is indicated in the treatment ofchronic obstructive pulmonary disease (COPD), includingchronic bronchitis and emphysema. The standard once-dailydose is 18 g of tiotropium.

Tiotropium bromide Preparation Products And Raw materials

Raw materials

Preparation Products


Tiotropium bromide Suppliers

Global( 240)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Anhui Dexinjia Biopharm Co., Ltd
86-531-82375818
86-531-82375893 alice@jndxj.com CHINA 129 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 sales@frappschem.com China 886 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21954 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 495 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 892 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8409 58

View Lastest Price from Tiotropium bromide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-17 Tiotropium bromide
136310-93-5
US $8.00 / kg 1kg 99% 10MT career henan chemical co
2018-12-21 Tiotropium Bromide cas136310-93-5(whatsapp:+8618830163278)
136310-93-5
US $5.00 / kg 1kg 99.97% 18ton/month Hebei Huanhao Biotechnology Co., Ltd.
2018-12-20 Tiotropium Bromide
136310-93-5
US $500.00 / g 10g 99%hplc 50tons Hebei Minshang Biotechnology Co., Ltd

136310-93-5(Tiotropium bromide)Related Search:


  • (1a,2,4,5a,7)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane Bromide
  • (1α,2β,4β,5α,7β-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0^<2,4>^]nonane bromide
  • Ba-679
  • Ba-679 BR
  • otropiuM broMide
  • TiotropiuM broMide anhydrous
  • (1R,2S,4R,5S,7R)-7-{[2-hydroxy-2,2-bis(thiophen-2-yl)acetyl]oxy}-9,9-diMethyl-3-oxa-9-azatricyclo[3.3.1.0^{2,4}]nonan-9-iuM broMide
  • TiotropiuM BroMide(Spiriva, BA 679BR)
  • (1α,2β,4β,5α,7β)-7-[(2-Hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-diMethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane BroMide
  • 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane,7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-diMethyl-, broMide (1:1), (1a,2b,4b,5a,7b)-
  • TiopropiuM
  • (1R,2R,4S,5S,7s)-7-(2-Hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-diMethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-iuM broMide
  • (1α,2β,4β,5α,7β)-7-[(Hy-droxydi-2-thienylacetyl)axy]-9,9-dimethyl-3-oxa-9-azoniatri-cyclo[3.3.1.02.4]nonane
  • (1a,2b,4b,5a,7b)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide
  • C19H22BrNO4S2H2O
  • C19H22NO4S2Br
  • Anhydrous Tiotropium Bromide
  • 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane, 7-[(2-hydroxy-2,2-di-2-thienylacetyl)oxy]-9,9-dimethyl-, bromide (1:1), (1α,2β,4β,5α,7β)-
  • (1R,2R,4S,5S,7s)-7-[(2-Hydroxy-2,2-dithiophen-2-ylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide monohydrate
  • Tiotropium Bromide cas136310-93-5(whatsapp:+8618830163278)
  • 136310-93-5
  • API
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • TIOTROPIUM BROMIDE
  • Tiotropium bromide, >=99%
  • -
  • Tiotropium
  • stock for supply, stable production, we can also offer commerical quantity
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