XR9576
- CAS No.
- 625375-83-9
- Chemical Name:
- XR9576
- Synonyms
- XR 9576;XR-9576;XR9576;XR9576 methanesulfonate;Tariquidar methanesulfonate;XR9576 methanesulfonate, hydrate;Tariquidar (Methanesulfonate, hydrate);Tariquidar dimethanesulfonate hexahydrate;Tariquidar methanesulfonate hydrate (XR9576);TARIQUIDAR METHANESULFONATE HYDRATE;XR 9576;XR-9576;N-[2-({4-[2-(6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]phenyl}carbamoyl)-4,5-dimethoxyphenyl]-3-quinolinecarboxamide
- CBNumber:
- CB82666691
- Molecular Formula:
- C39H42N4O9S
- Molecular Weight:
- 742.84
- MDL Number:
- MFCD25372040
- MOL File:
- 625375-83-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Tariquidar(methanesulfonate,hydrate) 98.38% | CS-1260 | 50mg | $290 |
| Tariquidarmethanesulfonate,hydrate | A3859 | 50mg | $293 |
| Tariquidar(methanesulfonate,hydrate) 98.38% | CS-1260 | 100mg | $490 |
| Tariquidar methanesulfonate hydrate | orb611537 | 100mg | $606.9 |
| Tariquidar methanesulfonate hydrate | orb611537 | 250mg | $912.9 |
XR9576 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1260 | Tariquidar(methanesulfonate,hydrate) 98.38% | 625375-83-9 | 50mg | $290 | 2021-12-16 | Buy |
| ApexBio Technology | A3859 | Tariquidarmethanesulfonate,hydrate | 625375-83-9 | 50mg | $293 | 2021-12-16 | Buy |
| ChemScene | CS-1260 | Tariquidar(methanesulfonate,hydrate) 98.38% | 625375-83-9 | 100mg | $490 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611537 | Tariquidar methanesulfonate hydrate | 625375-83-9 | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611537 | Tariquidar methanesulfonate hydrate | 625375-83-9 | 250mg | $912.9 | 2021-12-16 | Buy |
XR9576 Chemical Properties,Uses,Production
Uses
Tariquidar methanesulfonate, hydrate (XR9576 methanesulfonate, hydrate) is a potent and specific inhibitor of P-glycoprotein (P-gp) with a Kd of 5.1 nM.
in vivo
In mice bearing the intrinsically resistant MC26 colon tumors, coadministration of Tariquidar methanesulfonate, hydrate (XR9576 methanesulfonate, hydrate) potentiates the antitumor activity of Doxorubicin without a significant increase in toxicity; maximum potentiation is observed at 2.5-4.0 mg/kg dosed either i.v. or p.o. In addition, coadministration of Tariquidar (6-12 mg/kg p.o.) fully restores the antitumor activity of Paclitaxel, Etoposide, and Vincristine against two highly resistant MDR human tumor xenografts (2780AD, H69/LX4) in nude mice. Tariquidar is found to also significantly potentiate the antitumor activity of doxorubicin against s.c. MC26 tumors in vivo[2].
References
[1] Martin C, et al. The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein. Br J Pharmacol, 1999, 128(2), 403-411. DOI:10.1038/sj.bjp.0702807
[2] Mistry P, et al. In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576. Cancer Res, 2001, 61(2), 749-758. PMID:11212278
[3] Vraka C, et al. A new method measuring the interaction of radiotracers with the human P-glycoprotein (P-gp) transporter. Nucl Med Biol. 2018 Feb 14;60:29-36. DOI:10.1016/j.nucmedbio.2018.02.002
XR9576 Preparation Products And Raw materials
Raw materials
Preparation Products
XR9576 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3866 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4660 | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai Jiegu Biotechnology Co., Ltd. | 021-51698675 | sales@jiejiegroup.com | China | 8020 | 58 |
| Shanghai Zeye Biotechnology Co., Ltd. | 021-021-61998551 13122364865 | sale1@shzysw.net | China | 9778 | 58 |
