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Overview Properties Application Mode of action Toxicity and health effect Environmental problem References
Pendimethalin structure
Chemical Name:
PROWL;FRAMP;Stomp;waxup;wayup;AZOBAS;AcuMen;Way Up;PRESSTO;ac92553
Molecular Formula:
Formula Weight:
MOL File:

Pendimethalin Properties

Melting point:
Boiling point:
refractive index 
1.5700 (estimate)
Flash point:
11 °C
storage temp. 
Yellow-orange brown
Water Solubility 
<0.5 mg/L
NIST Chemistry Reference
EPA Substance Registry System
Benzenamine, N-(1-ethylpropyl)-3,4-dimethyl- 2,6-dinitro-(40487-42-1)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi;N,N,Xi,T,F
Risk Statements  43-50/53-39/23/24/25-23/24/25-11
Safety Statements  2-24-29-37-60-61-45-16-7-36/37
RIDADR  UN3077 9/PG 3
WGK Germany  2
RTECS  BX5470000
HazardClass  9
PackingGroup  III
Hazardous Substances Data 40487-42-1(Hazardous Substances Data)
Toxicity LC50 (96-hour) for rainbow trout 138 μg/L and bluegill sunfish 199 μg/L; acute oral LD50 of the technical product for male and female rats 1,250 and 1,050 mg/kg, respectively (Ashton and Monaco, 1991)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P501 Dispose of contents/container to..…

Pendimethalin price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 45892 Pendimethalin solution 100μg/mL in methanol, PESTANAL 40487-42-1 2ml $47.4 2018-11-20 Buy
Sigma-Aldrich 36191 Pendimethalin PESTANAL , analytical standard 40487-42-1 100mg $53 2018-11-13 Buy

Pendimethalin Chemical Properties,Uses,Production


Pendimethalin(PM) is a dinitroaniline herbicide, commonly used for the pre-emergence control of seedling grass and broad-leaved weeds in several broad-leaved crops and in corn, sugar cane and spring wheat. The primary mode of action of all herbicides from this group is by inhibition of cell mitosis that represses development of roots and shoots. PM selectivity is based on avoiding contact between the herbicide and the roots of the desired plants. As all dinitroaniline herbicides, it is highly volatile and undergoes some local leaching in soil[1]. This herbicide is widely used in the world. In 1992, approximately 9000 tons of pendimethalin were used for agricultural purposes in the US, most of them(approximately 60%) in soybean fields. In most of Illinois and Indiana, more than 4 kg of active ingredient(a.i.) km-2 were applied in 1992[2].
Pendimethalin was registered in 1972 for preemergent and postemergent control of broadleaf and grassy weeds on many crops, including: cotton, corn, sorghum, peanuts, rice, beans, peas, wheat, potatoes, soybeans, sunflowers, tobacco, ornamentals, non-bearing fruit and nut crops and vineyards. A systemic dinitroaniline herbicide, like oryzalin and trifluralin, the chemical inhibits germination and seedling development. Available as a granular or an emulsifiable concentrate, American Cyanamid trade names include: Prowl™, Stomp™, Herbadox™, and Pay-off™.

Figure 1 the chemical structure of pendimethalin ;


Pendimethalin appears as an orange-yellow crystalline solid with a faint nutty or fruit-like odor[4, 5]. Products containing pendimethalin range from slightly to highly flammable. They should not be stored, used or handled near heat or open flames[5]. It is slowly decomposed by light[3]. It is stable under normal temperatures and pressures, but it may pose a slight fire hazard if exposed to heat or flame. It poses a fire and explosion hazard in the presence of strong oxidizers. Thermal decomposition of pendimethalin will release toxic oxides of nitrogen and carbon[3].
Pendimethalin is strongly adsorbed by most soils, and its sorption is correlated to organic matter and clay content. Since it is practically insoluble in water, it will not leach appreciably in most soils and it is considered to present a minimal risk of groundwater contamination[6, 7]. Pendimethalin is strongly adsorbed by most soils, and its sorption is correlated to organic matter and clay content. Since it is practically insoluble in water, it will not leach appreciably in most soils and it is considered to present a minimal risk of groundwater contamination[6, 7].


Pendimethalin is a selective herbicide used for controlling most annual grasses and certain broadleaf weeds in field corn, potatoes, rice, cotton, soybeans, tobacco, peanuts and sunflowers. It is used both pre-emergence, that is before weed seeds have sprouted, and early post-emergence. Incorporated into the soil by cultivation or irrigation is recommended within 7 days following application. Pendimethalin is available as emulsifiable concentrate, wettable powder or dispersible granule formulations[5, 8].

Mode of action

It is a dinitroaniline herbicide that inhibits the steps in plant cell division responsible for chromosome separation and cell wall formation. It is used before crop emergence or planting[9]. It inhibits the development of roots and shoots in seedlings and is not translocated in plants[10, 11].

Toxicity and health effect

Pendimethalin is similar to other broad-spectrum herbicides in that it is phytotoxic to crop species to some extent. In the development of herbicides, screening experiments are conducted to ascertain extent of phytotoxicity to crops. The phytotoxicity of pendimethalin to crop species has been the focus in numerous experiments, for example, rice grain, and strawyield[12], root suppression of pampas grass[13], injury to seashore paspalum cultivars used for turf grass[14, 15], effect of repeated application on cotton yield and quality[16], cotton fiber quality and yield[17], and toxicity to selected springand summer-flowering bulbs and perennials[18].
Pendimethalin is not highly acutely toxic to animals. Interestingly, it is many times more acutely toxic by inhalation, LD50 = 320 mg/l, than by the oral or dermal routes, oral LD50 = 1250 mg/kg.2. In a chronic study, dogs ingesting 50 mg/kg or higher, developed liver damage, with increased liver weights. Tested rats developed similar effects[19].
Pendimethalin causes central nervous system depression in mice and rats[19]. In addition, the herbicide potentiates hypnosis caused by other drugs such as pentobarbitone, barbitone or ether, and lengthened recovery from drug effects.
The pesticide is highly toxic to fish and aquatic invertebrates, LD50=0.138-280 ppm. As a result, pendimethalin labels bear the following warning: This pesticide is toxic to fish and aquatic organisms. Fish may be killed at application rates recommended on the label.
Pendimethalin causes thyroid follicular cell adenomas in male and female rats,[20] and is classified as a possible human carcinogen(Group C) and is also a suspected endocrine disruptor. While no developmental effects were reported in the RED at the doses administered orally to rats and rabbits, maternal toxicity was observed at the highest doses tested(125, 250, 500 mg/kg/day) in rabbits, evidenced by increased mortality. Reproductive effects were found in rats at the highest dose tested[5000 ppm], based on pup body weight gain and possible decreased pups born alive and pup survival. Also, the percentage of apoptosis increased in mouse embryos exposed to low doses of pendimethalin, suggesting that at levels considered to be safe in humans pendimethalin has adverse effects very early in development[21]. Dietary exposure to pendimethalin and the cancer risk to the general population are low. Exposures to applicators, either commercial or residential, and occupational handlers are higher than for the general population, and are at a level of risk that is of concern. Pesticide applicators exposed to pendimethalin showed an exposure response for lung cancer[22].
A later study found no clear association of lifetime pendimethalin exposure with cancer incidence, but observed evidence of an elevated risk of lung cancer at the highest levels of exposure and an increased risk of rectal cancer in pendimethalin-exposed pesticide applicators compared to non-pendimethalin-exposed applicators[23].

Environmental problem

The widespread use of this herbicide has led to its detection as contaminant in surface water, air and precipitation by the U. S. Geological Survey’s National Water Quality Assessment(NAWQA) program[24, 25]. Mu¨ ller et al.(2002)[26] studied off-target movement of several pesticides by runoff. They reported that dissolved herbicides accounted for more than 99.5% of the total loss for most compounds tested at all rainfall intensities(acetochlor, atrazine, hexazinone and terbuthylazine), and the concentrations of the herbicides decreased with rainfall intensity. Pendimethalin behaved differently: 35% of the loss was estimated to be associated with sediment transport and variations in the pendimethalin concentrations were small(from 12 to 20 mg l-1) compared to variations detected over the same time period for other herbicides. There was no apparent temporal trend in dissolved pendimethalin concentrations for all treatments. This behavior is ascribed to the very low solubility and the relatively strong binding of pendimethalin to soil components, such as clays and organic matter[26].
Pendimethalin adsorbs strongly to soil organic matter and clay and does not leach through the soil to contaminate groundwater[4, 5, 27]. Pendimethalin is not subject to microbial degradation. Slight losses of pendimethalin can result from photodecomposition and volatilization. When used according to label instructions, no carry over to subsequent crops is expected[27].


  1. Anderson, W.P., 1996. Dinitroaniline herbicides. Weed Science: Principles and Applications, 3rd edn. West Publishing, St. Paul, MN, pp. 184–187.
  2. USGS National Water Quality Assessment Program: annual use maps, 1998. Available at: index.html [Online].
  3. Occupational Health Services, Inc. 1991[Feb. 21]. MSDS for Pendimethalin. OHS Inc., Secaucus, NJ.
  4. U.S. Department of Agriculture, Soil Conservation Service. 1990[Nov.]. SCS/ARS/CES Pesticide Properties Database: Version 2.0[Summary]. USDA - Soil Conservation Service, Syracuse, NY.
  5. WSSA Herbicide Handbook Committee. 1989. Herbicide Handbook of the Weed Science Society of America, 6th Ed. WSSA, Champaign, IL.
  6. Wauchope, R.D., Buttler, T.M., Hornsby, A.G., Augustijn Beckers, P.W.M., Burt, J.P., 1992. SCS/ARS/CES Pesticide properties database for environmental decision making. Rev. Environ. Contam. Toxicol. 123, 1– 157.
  7. Weed Science Society of America, 1994. Herbicide Handbook, Seventh edition. Weed Science Society of   America, Champaign, IL.
  8. Meister, R.T.[ed.]. 1992. Farm Chemicals Handbook '92. Meister Publishing Company, Willoughby, OH.
  9. Richardson, M.L., Gangolli, S.E.,[Eds.], 1994. The Dictionary of Substances and Their Effects., Vol. 6. The Royal Society of Chemistry, Clays Ltd., Cambridge, UK, pp. 431–432.
  10. Appleby, J.R., Valverde, B.E., 1988. Behavior of dinitroaniline herbicides in plants. Weed Technol. 3, 198–206.
  11. Gilliam, C.H., Eakes, D.J., Olive, J.W., 1993. Herbicide use during propagation affects root initiation and development. J. Environ. Hort. 11, 157–159.
  12. Devi, L.S., Gowda, R.S.D.B., 1985. Studies on efficacy of pendimethalin: 2. Pesticides 19, 41–43.
  13. Green, J.C., Keever, G.J., Gilliam, C.H., Palmer, C.K., Olive, J.W., Eakes, D.J., 1997. Effects of preemergence-applied herbicides on pampas grass grown in containers. J. Environ. Hort. 15, 77–80.
  14. Johnson, B.J., Duncan, R.R., 1998a. Tolerance of seashore paspalum cultivars to preemergence herbicides. J. Environ. Hort. 16, 76–78.
  15. Johnson, B.J., Duncan, R.R., 1998b. Influence of herbicides on establishment of eight seashore paspalum cultivars. J. Environ. Hort. 16, 79–81.
  16. Keeling, J.W., Abernathy, J.R., 1989. Response of cotton[Gossypium hirsutum] to repeated applications of dinitroaniline herbicides. Weed Technol. 3, 527–530.
  17. Keeling, J.W., Dotray Peter, A., Abernathy John, R., 1996. Effects of repeated applications of trifluralin and pendimethalin on cotton[Gossypium hirsutum]. Weed Technol. 10, 295–298.
  18. Skroch, W.A., Catanzaro, C.J., De Hertogh, A.A., Gallitano, L.B., 1994. Preemergence herbicide evaluations on selected spring and summer flowering bulbs and perennials. J. Environ. Hort. 12, 80–82.
  19. Garg, S.K., et al. 1987. Neurotoxic effects of pendimethalin - a weedicide. Indian J. Exper. Biol. 25:463-6.
  20. Hurley, P.M., R.N. Hill, & R.J. Whiting. 1998. Mode of Carcinogenic Action of Pesticides Inducing Thyroid Follicular Cell Tumors in Rodents. Envrionmental Health Perspectives 106(8]:437-45.
  21. Greenlee, A.R., T.M. Ellis, & R.L. Berg. 2004. Low-dose agrochemicals and lawn-care pesticides induce developmental toxicity in murine preimplantation embryos. Environmental Health Perspectives 112(6]:703-9.
  22. Alavanja, M.C., et al. 2004. Pesticides and lung cancer risk in the agricultural health study cohort. American Journal of Epidemiology 160(9]:876-85.
  23. Hou, L., et al. 2006. Pendimethalin exposure and cancer incidence among pesticide applicators. Epidemiology 17(3]:302-7.
  24. Capel, P.D., Lin, M., Wotzka, P.J., 1998. Wet Atmospheric Deposition of Pesticides in Minnesota, 1989–1994. U.S. Geological Survey, Mounds View, MN.
  25. Larson, S.J., Gilliom, R.J., Capel, P.D., 1999. Pesticides in streams of the United States—initial results from the National Water-Quality Assessment Program U.S. Geological Survey Water-Resources Investigations Report 98-4222, 92 pp. Sacramento, CA.
  26. Mqller, K., Trolove, M., James, T.K., Rahman, A., 2002. Herbicide runoff studies in an arable soil under simulated rainfall. N. Z. Plant Prot. 55, 172– 176.
  27. 1985[March 31]. Chemical Fact Sheet For: Pendimethalin[Fact Sheet No. 50]. Office of Pesticide Programs, US EPA, Washington, DC.

Chemical Properties

Brown Solid

Chemical Properties

Yellow-orange crystalline solid. Mild nut-like odor. Commercial product is available as an emulsifiable concentrate.


Herbicide used to control the spread of weedgrass.


ChEBI: A member of the class of substituted anilines that is N-(pentan-3-yl)aniline bearing two additional nitro substituents at positions 2 and 6 as well as two methyl substituents at positions 3 and 4. A herbicide used to control most annual rasses and many annual broad-leaved weeds.




used to control many annual grasses and broad-leaved weeds in crops such as corn, cotton, peanuts, potatoes, rice, sorghum, sunflower and tobacco.

General Description

Orange-yellow crystals. Non corrosive. Used as an herbicide.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A dinitroaniline derivative.

Agricultural Uses

Herbicide: Pendimethalin is a selective pre-emergence and post-emergence herbicide used on various agricultural and non-agricultural sites to control broadleaf weeds and grassy weeds in crops such as apricot, carrot, cherry, corn, cotton, fig, garbanzos, garlic, olive, onion, nectarine, peach, pear, pecan, plum, rice and prune, and noncrop areas. It is applied to soil preplant, pre-emergence, and post-emergence with ground and aerial equipment.

Trade name


Potential Exposure

Pendimethalin is a selective preemergence and postemergence 2,6-dinitroaniline herbicide used on various agricultural and non-agricultural sites to control broadleaf weeds and grassy weeds in crops such as apricot, carrot, cherry, corn, cotton, fig, garbanzos, garlic, olive, onion, nectarine, peach, pear, pecan, plum, rice and prune, and noncrop areas. It is applied to soil preplant, pre-emergence, and postemergence with ground and aerial equipment.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions) if breathing has stopped, and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Do not induce vomiting when formulations containing petroleum solvents are ingested

Environmental Fate

Biological. In an in vitro study, the soil fungi Fusarium oxysporum and Paecilomyces varioti degraded pendimethalin to N-(1-ethylpropyl)-3,3-dimethyl-2-nitrobenzene-1,6- diamine and 3,4-dimethyl-2,6-dinitroaniline. The latter compound was the only metabolite identified by another soil fungus; namely, Rhizoctonia bataticola (Singh and Kulshrestha, 1991)
Kole et al. (1994) studied the degradation of pendimethalin by an unadapted strain of Azotobacter chroococcum Beijerinck in pure culture condition. Degradation was rapid — 45 and 55% of the parent compound was degraded after 10 and 20 days, respectively.
xylidine. At the C-3 position on the parent compound, the methyl group oxidized to -CH2OH which underwent partial reduction of the 2-nitro group and N-dealkylation followed by oxidative cyclization to give 2-methyl-4-nitro-5-N-(1-cyclopropyl)-6-nitrosobe
Soil/Plant. In soil, the 4-methyl group on the benzene ring is oxidized to a hydroxy group which undergoes further oxidation to the carboxylic acid. The major plant metabolite is 4-(1-ethylpropyl)amino-2-methyl-3,5-dinitrobenzyl alcohol (Hartley and Kidd, 1987). Kulshrestha and Singh (1992) investigated the influence of soil moisture and microbial activity on the degradation of pendimethalin in a sandy loam soil. In both nonsterile, nonflooded and flooded soils, degradation followed first-order kinetics. The observed halflives in flooded and nonflooded conditions in nonsterile and sterile soils were 33 and 45; 52 and 67 days, respectively. In the nonsterile, nonflooded soil, pendimethalin underwent N-dealkylation and reduction of the less hindered nitro group affording N-(1-ethylpropyl)- 3,4-dimethyl-2-nitrobenzene-1,6-diamine and 3,4-dimethyl-2,6-dinitroaniline as major products. Under flooded conditions, only one degradation product was formed: N-(1- ethylpropyl)-5,6-dimethyl-7-nitrobenzimidazole. Under flooded conditions, pendimethalin was completely degraded after 4 days (Kulshrestha and Singh, 1992)
The reported half-lives of pendimethalin in a Sharkey clay soil and Bosket silt loam are 6 and 4 days, respectively (Savage and Jordan, 1980).

Metabolic pathway

Irradiation of pendimethalin in methanol yields, in addition to the minor dealkylated product, the major products 2-amino-6-nitro-N-(1-ethylpropyl)-3,4-xylidine and 2-nitroso-6-nitro-3,4-xylidine. Pendimethalin degrades rapidly through reductive cyclization of the amino group and adjacent N-ethylpropyl to give a cyclized benzimidazole product. The photodecomposition of pendimethalin involves oxidative dealkylation, nitro reduction, and cyclization. By soil bacteria, pendimethalin degrades through different pathways from the photodegradation reaction, resulting in benzimidazole and hydroxylated products of the N-alkyl and xylyl methyl groups. The major metabolic routes of pendimethalin by rats involves hydroxylation of the 4-methyl and the N-ethyl group, oxidation of these alkyl groups to carboxylic acids, nitro reduction, cyclization, and conjugation in the urine and the tissues. Products of cyclization reactions giving methylbenzimidazole-carboxylic acids are unique metabolites to the liver and kidney.


UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.


Reacts with oxidizers, acids and alkaline materials. Contact with strong oxidizers may cause fire and explosions.

Waste Disposal

It is the responsibility of chemical waste generators to determine if a discarded chemical is classified as a hazardous waste. See 40 CFR Parts 261.3 for United States Environmental Protection Agency guidelines for the classification determination. Additionally, in order to ensure complete and accurate classification, waste generators must consult state and local hazardous waste regulations. Organic pesticides, whether of botanical or synthetic origin, can be destroyed by incineration equipped with scrubbers to remove acid wastes.

Pendimethalin Preparation Products And Raw materials

Raw materials

Preparation Products

Pendimethalin Suppliers

Global( 173)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22043 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20786 55
Mainchem Co., Ltd.
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86-21-51861608;;; CHINA 24118 58
Hubei Jusheng Technology Co.,Ltd.
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Hebei Jimi Trading Co., Ltd.
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Haihang Industry Co.,Ltd
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Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651 CHINA 901 58
Hebei Chisure Biotechnology Co., Ltd.
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View Lastest Price from Pendimethalin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-03-26 Factory supply Pendimethalin 40487-42-1 powder in stock
US $1.00 / kg 1 kg/桶 99% 20tons Hebei Jimi Trading Co., Ltd.
2018-07-10 Pendimethalin
US $10.00 / KG 10KG 99% 1000 ton / month Hebei Chisure Biotechnology Co., Ltd.

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