Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Tariquidar

Tariquidar

Tariquidar Structure
Tariquidar structure
CAS No.
206873-63-4
Chemical Name:
Tariquidar
Synonyms
Xr9576;CS-678;XL9576;D06008;Xr 9576;Tariquidar;Unii-J58862dtvd;XL9576 Free base;Tariquidar, >=98%;Tariquidar(XR9576)
CBNumber:
CB71456926
Molecular Formula:
C38H38N4O6
Molecular Weight:
646.73
MDL Number:
MFCD09837824
MOL File:
206873-63-4.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:06
Request For Quotation

Tariquidar Properties

Melting point >190oC (dec.)
Boiling point 716.0±60.0 °C(Predicted)
Density 1.276±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
pka 10.67±0.70(Predicted)
form powder
color white to light brown
NCI Dictionary of Cancer Terms tariquidar; XR9576
FDA UNII J58862DTVD
NCI Drug Dictionary tariquidar

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Tariquidar price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1790 Tariquidar ≥98% (HPLC) 206873-63-4 5MG $135 2023-06-20 Buy
Sigma-Aldrich SML1790 Tariquidar ≥98% (HPLC) 206873-63-4 25MG $542 2023-06-20 Buy
Cayman Chemical 24180 Tariquidar ≥95% 206873-63-4 5mg $61 2024-03-01 Buy
Cayman Chemical 24180 Tariquidar ≥95% 206873-63-4 10mg $112 2024-03-01 Buy
Cayman Chemical 24180 Tariquidar ≥95% 206873-63-4 25mg $264 2024-03-01 Buy
Product number Packaging Price Buy
SML1790 5MG $135 Buy
SML1790 25MG $542 Buy
24180 5mg $61 Buy
24180 10mg $112 Buy
24180 25mg $264 Buy

Tariquidar Chemical Properties,Uses,Production

Description

Tariquidar is an anthranilic acid derivative that binds to P-glycoprotein (Kd = 5.1 nM) and inhibits transport activity. It inhibits transport of vinblastine and paclitaxel in multidrug resistant CHrB30 cells, increasing the steady state accumulation to non-P-glycoprotein-expressing multidrug sensitive cell levels (EC50 = 487 nM). Tariquidar also enhances the distribution of its substrates, increasing the amount of substrate entering the CNS. When administered at doses of 2 and 6.25 mg/kg in mice in combination with the peripherally-restricted opioid loperamide, the latency to paw withdrawal in a hot plate assay increases, indicating that loperamide is transported into the CNS.

Uses

Tariquidar is a p-glycoprotein drug efflux pump inhibitor. Tariquidar inhibits the ATPase activity of P-glycoprotein, suggesting that the modulating effect is derived from the inhibition of substrate binding, inhibition of ATP hydrolysis or both.Tariquidar can be considered an ideal agent for testing the role of P-glycoprotein inhibition in cancer.

Uses

Tariquidar is a p-glycoprotein drug efflux pump inhibitor. Tariquidar inhibits the ATPase activity of P-glycoprotein, suggesting that the modulating effect is derived from the inhibition of substrate binding, inhibition of ATP hydrolysis or both.Tariquidar can be considered an ideal agent for testing the role of P-glycoprotein inhibition in cancer

Definition

ChEBI: Tariquidar is a member of benzamides.

Biochem/physiol Actions

Specific inhibitor of MDR-1 (P-gp)

target

P-glycoprotein

Tariquidar Preparation Products And Raw materials

Raw materials

Preparation Products

Tariquidar Suppliers

Global( 157)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Changzhou PBpharmaceutical R&D Co.,Ltd 		0519-83990708 info@pbpharm.com CHINA 498 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chengdu Feibo Pharm Technology Co., Ltd 		15982321820 abby@arkpharm.com CHINA 3279 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29220 58
Baoji Guokang Bio-Technology Co., Ltd. 		0917-3909592 13892490616 gksales1@gk-bio.com China 9339 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Alfa Chemistry 		+1-5166625404 Info@alfa-chemistry.com United States 21317 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Changzhou PBpharmaceutical R&D Co.,Ltd 		58
BOC Sciences 		58
Chengdu Feibo Pharm Technology Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Dideu Industries Group Limited 		58
Baoji Guokang Bio-Technology Co., Ltd. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Alfa Chemistry 		58

View Lastest Price from Tariquidar manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tariquidar pictures 2022-10-14 Tariquidar
206873-63-4
 US $0.00-0.00 / KG 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
Tariquidar pictures 2021-07-13 Tariquidar
206873-63-4
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Tariquidar pictures 2021-07-10 Tariquidar
206873-63-4
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
  • Tariquidar pictures
  • Tariquidar
    206873-63-4
  • US $0.00-0.00 / KG
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.
  • Tariquidar pictures
  • Tariquidar
    206873-63-4
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd
  • Tariquidar pictures
  • Tariquidar
    206873-63-4
  • US $15.00-10.00 / KG
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

Tariquidar Spectrum

Tariquidar(206873-63-4)1HNMR

206873-63-4(Tariquidar)Related Search:

Diphenyldiethoxysilane XR9576 AC480 (BMS-599626) ISOXADIFEN-ETHYL PHENYL VALERATE
p-(2-Methoxyethyl) phenol Diphenyldimethoxysilane Ethyl acetate Ethyl acrylate Ethyl formate
Ethanol Ethylparaben 4-Methoxyphenylacetone Isoquinoline Methoxydiethylborane
PHENYL RESIN 4-[2-(3,4-DIHYDRO-6,7-DIMETHOXY-2(1H)-ISOQUINOLINYL)ETHYL]-BENZENAMINE Tariquidar

1of4

N-[2-[[[4-[2-(3,4-Dihydro-6,7-diMethoxy-isoquinolin-2(1H)-yl)ethyl]phenyl]aMino]carbonyl]-4,5-diMethoxyphenyl]-3-quinolinecarboxaMide N-[2-({4-[2-(6,7-diMethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]phenyl}carbaMoyl)-4,5-diMethoxyphenyl]quinoline-3-carboxaMide N-[2-[[4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide Tariquidar Tariquidar N-[2-[[4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide Tariquidar, >=98% XL9576 Free base N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxy-phenyl]quinoline-3-carboxamide Tariquidar 3-Quinolinecarboxamide, N-(2-(((4-(2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl)phenyl)amino)carbonyl)-4,5-dimethoxyphenyl)- N-(2-((4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)carbamoyl)-4,5-dimethoxyphenyl)quinoline-3-carboxamide Unii-J58862dtvd Xr 9576 N-[2-[N-[4-[2-(6,7-DiMethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]phenyl]carbaMoyl]-4,5-diMethoxyphenyl]quinoline-3-carboxaMide Tariquidar(XR9576) CS-678 XL9576 D06008 XR 9576;XR-9576;D06008 Tariquidar USP/EP/BP Xr9576 206873-63-4 C38H38N4O6 Inhibitors Anti-cancer&immunity Inhibitor