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ChemicalBook >> CAS DataBase List >>(R)-4-Propyldihydrofuran-2(3H)-one

(R)-4-Propyldihydrofuran-2(3H)-one

(R)-4-Propyldihydrofuran-2(3H)-one Structure
(R)-4-Propyldihydrofuran-2(3H)-one structure
CAS No.
63095-51-2
Chemical Name:
(R)-4-Propyldihydrofuran-2(3H)-one
Synonyms
(R)-4-propyl-dihydro-furan-2-one;(4R)-4-Propyldihydrofuran-2(3H)-one;(4R)-4-propyloxolan-2-one;(4R)-4-propyltetrahydrofuran-2-one;(R)-Dihydro-4-propylfuran-2(3H)-one;(R)-Dihydro-4-propyl-2(3H)-furanone;BR150;Brisetan;Boisacetan;Buvacitan impurity 11
CBNumber:
CB82747297
Molecular Formula:
C7H12O2
Molecular Weight:
128.17
MDL Number:
MFCD29905061
MOL File:
63095-51-2.mol
MSDS File:
SDS
Last updated:2023-11-16 16:15:21
Request For Quotation

(R)-4-Propyldihydrofuran-2(3H)-one Properties

Boiling point 226.3±8.0 °C(Predicted)
Density 0.983±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form Oil
color Colourless
FDA UNII LP4GE5VL92

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H317
Precautionary statements  P280

(R)-4-Propyldihydrofuran-2(3H)-one price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D495305 (R)-Dihydro-4-propyl-2(3H)-furanone 63095-51-2 1g $315 2021-12-16 Buy
American Custom Chemicals Corporation APN0002377 (R)-4-PROPYLDIHYDROFURAN-2(3H)-ONE 95.00% 63095-51-2 5MG $504.94 2021-12-16 Buy
AK Scientific 2796CS (R)-4-Propyldihydrofuran-2(3H)-one 63095-51-2 1g $223 2021-12-16 Buy
Ambeed A230886 (R)-4-Propyldihydrofuran-2(3H)-one 97% 63095-51-2 25g $1105 2021-12-16 Buy
Chemenu CM244546 (R)-4-Propyldihydrofuran-2(3H)-one 99% 63095-51-2 1000g $3128 2021-12-16 Buy
Product number Packaging Price Buy
D495305 1g $315 Buy
APN0002377 5MG $504.94 Buy
2796CS 1g $223 Buy
A230886 25g $1105 Buy
CM244546 1000g $3128 Buy

(R)-4-Propyldihydrofuran-2(3H)-one Chemical Properties,Uses,Production

Description

(R)-4-Propyldihydrofuran-2(3H)-one is the key intermediate in the diastereoselective synthesis of Brivaracetam, an active ingredient with antiepileptic properties belonging to the racetam family.

Chemical Properties

(R)-4-Propyldihydrofuran-2(3H)-one is a yellow oily liquid, slightly soluble in chloroform, methanol and ethanol. It needs to be stored at 2-8°C.

Uses

(R)-Dihydro-4-propyl-2(3H)-furanone, is building block used in various chemical synthesis.

Synthesis

Add a solution of H5IO6 (24.429 g, 107.17 mmol) in water (43 mL) to a solution of (R)-2-benzylpentyl acetate (1.180 g) in CCl4 (27 mL) and CH3CN (27 mL) at 0 °C. Add RuCl3·nH2O (0.222 g, 1.07 mmol) slowly to the mixture at 0 °C. Stir the resultant mixture vigorously for 20 hours at room temperature. Quench the reaction with Et2O (50 mL) at 0 °C. Stir the mixture for 30 minutes. Extract the mixture with Et2O (3 × 50 mL).
Wash the combined organic layers with brine (30 mL). Dry the combined organic layers over anhydrous Na2SO4. Filter the combined organic layers. Remove the solvent. Dissolve the oil in aqueous NaOH (1 mol L-1, 40 mL). Stir the resulting solution overnight at room temperature. Wash the solution with Et2O (30 mL). Acidify the solution with aqueous HCl (6 mol L-1, 15 mL) at 0 °C. Stir the mixture overnight at room temperature. Saturate the aqueous layer with NaCl. Extract the mixture with Et2O (5 × 40 mL). Wash the combined organic layers with water, saturated aqueous Na2S2O3 (30 mL) and brine (30 mL).
Dry the combined organic layers over anhydrous Na2SO4. Filter the combined organic layers. Remove the solvent. Purify the residue by column chromatography on silica gel (hexane/acetone = 3/1) and distillation (162-209 °C/36 mmHg).The synthetic method 2 of (R)-4-Propyldihydrofuran-2(3H)-one

(R)-4-Propyldihydrofuran-2(3H)-one synthesis

112106-16-8
63095-51-2
Synthesis of (R)-4-Propyldihydrofuran-2(3H)-one from (R)-2-(2-(tert-butoxy)-2-oxoethyl)pentanoic acid

(R)-4-Propyldihydrofuran-2(3H)-one Preparation Products And Raw materials

Raw materials

2(3H)-Furanone, dihydro-4-(2-propenyl)-, (R)- (9CI) (R)-2-(2-(tert-butoxy)-2-oxoethyl)pentanoic acid Dihydro-4-propyl-2(3H)-furanone 2(5H)-Furanone, 4-propyl- (R)-tert-butyl 3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)hexanoate

Preparation Products

Brivaracetam (alfaR, 4R)-Isomer

(R)-4-Propyldihydrofuran-2(3H)-one Suppliers

Global( 280)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Boc Chemical Co., Ltd.
021-34975602; +8618721111801 shangli@bocchem.com China 138 58
Chengdu Aupone Pharmaceutical Co.Ltd.
+86-28-+86-28-87843998-6060-6060 +8618631098571 lijiaqi@aupone.com China 43 58
Hebei Xinsheng New Material Technology Co., LTD. 		+86-16632316109 xinshengkeji@xsmaterial.com China 1100 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15932 58
Nanjing Gold Pharmaceutical Technology Co. Ltd. 		025-84209270 15906146951 CHINA 115 55
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9346 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Supplier Advantage
Shanghai Boc Chemical Co., Ltd.
58
Chengdu Aupone Pharmaceutical Co.Ltd.
58
Hebei Xinsheng New Material Technology Co., LTD. 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Nanjing Gold Pharmaceutical Technology Co. Ltd. 		55
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58

Related articles

View Lastest Price from (R)-4-Propyldihydrofuran-2(3H)-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-4-Propyldihydrofuran-2(3H)-one pictures 2023-11-16 (R)-4-Propyldihydrofuran-2(3H)-one
63095-51-2
 US $35.00-25.00 / kg 1kg 99% 20 Ton Hebei Xinsheng New Material Technology Co., LTD.
(R)-4-Propyldihydrofuran-2(3H)-one pictures 2021-08-12 (R)-4-Propyldihydrofuran-2(3H)-one
63095-51-2
 US $40.00 / KG 1KG 99 10 tons Shijiazhuang tongyang Import and Export Co., LTD
Brivaracetam Intermediate pictures 2020-02-26 Brivaracetam Intermediate
63095-51-2
 US $0.00-0.00 / Kg 100G 99.0%+ 100 tons Shaanxi Dideu Medichem Co. Ltd

63095-51-2((R)-4-Propyldihydrofuran-2(3H)-one)Related Search:

(R)-Ethyl 3-(bromomethyl)hexanoate Brivaracetam Impurity 10 Brivaracetam Impurity 14 (Z)-2-propylhept-2-enal INTERMEDIATES
tert-Butyl (R)-4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate (R)-2-(2-(tert-butoxy)-2-oxoethyl)pentanoic acid Brivaracetam Impurity 21 Brivaracetam-d7 Dihydro-4-propyl-2(3H)-furanone
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(R)-4-Propyldihydrofuran-2(3H)-one Brivaracetam brivaracetam intermediate 3

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brivaracetam intermediate 1 Brivaracetam Intermediate (R)-4-propyldihydrofuran-2(3H)-one (+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one 2(3H)-Furanone,dihydro-4-propyl-,(R)- Boisacetan Brivaracetam Impurity 13 (+)-(R)-4-propyl-4,5-dihydroturan-2(3H)-one 2(3H)-Furanone, dihydro-4-propyl-, (R)- (9CI) (R)-4-propyl-4,5-dihydrofuran-2(3H)-one(BR50) Brivaracetam Impurity 40 (+)-(R)-4-propyl-4,5- dihydrofuran-2(3H)-one (R)-4-Propyldihydrofuran-2(3H)-one(For export only) (4R)-4-propyltetrahydrofuran-2-one (4R)-4-propyloxolan-2-one (R)-Dihydro-4-propylfuran-2(3H)-one (4R)-4-Propyldihydrofuran-2(3H)-one (R)-4-propyl-dihydro-furan-2-one (R)-Dihydro-4-propyl-2(3H)-furanone Brisetan (R)-4-Propyldihydrofuran-2(3H)-One/ Intermediate Of Brivaracetam BR150 (R)-4-Propyldihydrofuran-2(3H)-one(Briveracetam KSM) Buvacitan impurity 11 (R)-4-propyI-dihydro-furan-2-one (R)-4-propylidihydrofuran-2(3H)-4-one 63095-51-2